{"id":"placebo-metformin","safety":{"commonSideEffects":[{"rate":"20–30","effect":"Gastrointestinal disturbance (nausea, diarrhea, abdominal discomfort)"},{"rate":"3–5","effect":"Metallic taste"},{"rate":"10–30","effect":"Vitamin B12 deficiency"},{"rate":"<0.1","effect":"Lactic acidosis (rare)"}]},"_chembl":{"chemblId":"CHEMBL1431","moleculeType":"Small molecule","molecularWeight":"129.17"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metformin is a biguanide that primarily works by decreasing gluconeogenesis in the liver and enhancing peripheral glucose uptake and utilization. It may also improve insulin secretion and reduce intestinal glucose absorption. The drug does not stimulate insulin release, making it weight-neutral and suitable for use across a range of patient populations.","oneSentence":"Metformin reduces hepatic glucose production and improves insulin sensitivity, thereby lowering blood glucose levels in type 2 diabetes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:01:09.295Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT02122185","phase":"PHASE2","title":"Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer","status":"COMPLETED","sponsor":"University of Chicago","startDate":"2015-02-25","conditions":"Brenner Tumor, Malignant Ascites, Malignant Pleural Effusion","enrollment":111},{"nctId":"NCT07485764","phase":"PHASE4","title":"Metformin Combined With Secukinumab for Moderate-to-Severe Plaque Psoriasis in Overweight or Obese Chinese Patients","status":"NOT_YET_RECRUITING","sponsor":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","startDate":"2026-06","conditions":"Psoriasis, Plaque Psoriasis, Moderate-to-severe Plaque Psoriasis","enrollment":186},{"nctId":"NCT05013112","phase":"NA","title":"Ameliorating Metabolic Profiling After Kidney Transplantation (AMPKT)","status":"COMPLETED","sponsor":"West China Hospital","startDate":"2023-01-01","conditions":"Kidney Transplantation, Metabolic Disorder, Metformin","enrollment":105},{"nctId":"NCT07045142","phase":"PHASE3","title":"Metformin Alleviates Abnormal Glucose Metabolism Induced by Statins in Schizophrenia Patients","status":"RECRUITING","sponsor":"Central South University","startDate":"2025-07-01","conditions":"Schizophrenia","enrollment":400},{"nctId":"NCT07475546","phase":"PHASE3","title":"Combination Gerotherapeutic Interventions for Healthspan Improvement","status":"ACTIVE_NOT_RECRUITING","sponsor":"AgelessRx","startDate":"2025-07-23","conditions":"Healthspan Improvement, Aging, Longevity","enrollment":30},{"nctId":"NCT06231758","phase":"PHASE3","title":"Metformin Safety and Efficacy in Osteoarthritis.","status":"RECRUITING","sponsor":"Mostafa Bahaa","startDate":"2024-01-30","conditions":"Osteo Arthritis Knee","enrollment":70},{"nctId":"NCT01351753","phase":"PHASE2","title":"Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity","status":"TERMINATED","sponsor":"University of Iowa","startDate":"2011-03","conditions":"Obesity, Metabolic Syndrome X","enrollment":128},{"nctId":"NCT04596631","phase":"PHASE3","title":"A Research Study to Compare a New Medicine Oral Semaglutide to a Dummy Medicine in Children and Teenagers With Type 2 Diabetes","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2020-11-02","conditions":"Diabetes Mellitus, Type 2","enrollment":132},{"nctId":"NCT07433062","phase":"PHASE1","title":"A Study to Evaluate the Effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants With Type 2 Diabetes Mellitus","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2026-01-14","conditions":"Type 2 Diabetes Mellitus","enrollment":28},{"nctId":"NCT05279768","phase":"PHASE1, PHASE2","title":"Stem Cells and Secretomes for Infertility Therapy in Polycystic Ovary Syndrome (PCOS) Patients With Insulin Resistance.","status":"COMPLETED","sponsor":"PT. Prodia Stem Cell Indonesia","startDate":"2022-09-01","conditions":"Polycystic Ovary Syndrome","enrollment":44},{"nctId":"NCT06611501","phase":"PHASE2","title":"Glycemic Regulation as Endometriosis Adjunct Treatment","status":"RECRUITING","sponsor":"Boston Children's Hospital","startDate":"2025-05-22","conditions":"Pelvic Pain, Endometriosis","enrollment":14},{"nctId":"NCT03514108","phase":"PHASE4","title":"DANHEART (H-HeFT and Met-HeFT)","status":"COMPLETED","sponsor":"Henrik Wiggers","startDate":"2018-03-01","conditions":"Heart Failure, Diabetes","enrollment":1100},{"nctId":"NCT05900284","phase":"PHASE2","title":"Safety and Feasibility of Metformin for Sepsis Induced AKI","status":"ENROLLING_BY_INVITATION","sponsor":"Hernando Gomez","startDate":"2023-11-08","conditions":"Sepsis, Septic Shock, Acute Kidney Injury","enrollment":80},{"nctId":"NCT07395895","phase":"PHASE3","title":"Effect of Metformin Iontophoresis on Knee Osteoarthritis in Postmenopausal Women","status":"NOT_YET_RECRUITING","sponsor":"Badr University","startDate":"2026-03-01","conditions":"Osteoarthritis in Postmenopausal Women","enrollment":68},{"nctId":"NCT04850846","phase":"PHASE2","title":"Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2021-04-27","conditions":"Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma","enrollment":60},{"nctId":"NCT07395960","phase":"PHASE1, PHASE2","title":"The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-09-01","conditions":"Mild Cognitive Impairment, Overweight or Obesity, Elderly","enrollment":54},{"nctId":"NCT07387900","phase":"PHASE2","title":"Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-02","conditions":"Oral Leukoplakia","enrollment":34},{"nctId":"NCT06961019","phase":"NA","title":"Clinical Study to Assess the Safety, Efficacy and In-Use Tolerability of Herbal-Based Sugar Support Effervescent Tablets in Type-2 Diabetes Mellitus Patients","status":"RECRUITING","sponsor":"NovoBliss Research Pvt Ltd","startDate":"2025-08-25","conditions":"Type2 Diabetes Mellitus","enrollment":14},{"nctId":"NCT06090227","phase":"PHASE1, PHASE2","title":"AMPK-activation by Metformin in FSGS: AMP-FSGS","status":"RECRUITING","sponsor":"Yale University","startDate":"2023-12-14","conditions":"Focal Segmental Glomerulosclerosis","enrollment":30},{"nctId":"NCT04196868","phase":"PHASE2","title":"Methotrexate and Metformin in Rheumatoid Arthritis Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2020-12-03","conditions":"Arthritis, Rheumatoid","enrollment":128},{"nctId":"NCT07379333","phase":"PHASE3","title":"A Study to Evaluate Efficacy and Safety of HM11260C in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin","status":"NOT_YET_RECRUITING","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2026-02","conditions":"Type 2 Diabetes","enrollment":118},{"nctId":"NCT04341571","phase":"PHASE2","title":"Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes.","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Guadalajara","startDate":"2019-10-24","conditions":"PreDiabetes, Impaired Glucose Tolerance, Hyperglycemia","enrollment":30},{"nctId":"NCT05230758","phase":"PHASE3","title":"Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour","status":"RECRUITING","sponsor":"Donald Mabbott","startDate":"2022-07-01","conditions":"Medulloblastoma, Childhood, Cognitive Impairment","enrollment":140},{"nctId":"NCT06065540","phase":"PHASE3","title":"A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2023-09-27","conditions":"Type 2 Diabetes Mellitus","enrollment":2734},{"nctId":"NCT06273072","phase":"PHASE2","title":"Metformin IN Asthma for Overweight and Obese Individuals (MINA)","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2024-12-09","conditions":"Asthma, Asthma Chronic, Overweight and Obesity","enrollment":100},{"nctId":"NCT07007221","phase":"PHASE2","title":"Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV","status":"NOT_YET_RECRUITING","sponsor":"University of Minnesota","startDate":"2026-07-01","conditions":"Depression, Hiv","enrollment":600},{"nctId":"NCT03862950","phase":"PHASE2","title":"A Trial of Metformin in Individuals With Fragile X Syndrome (Met)","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2019-05-24","conditions":"Fragile X Syndrome, Fragile X Mental Retardation Syndrome, Mental Retardation, X-Linked","enrollment":125},{"nctId":"NCT00971243","phase":"PHASE2","title":"Efficacy and Safety of MP-513 in Combination With Metformin in Patients With Type 2 Diabetes","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2009-08","conditions":"Type 2 Diabetes Mellitus","enrollment":448},{"nctId":"NCT05093959","phase":"PHASE2","title":"Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2022-01-04","conditions":"Heart Failure With Preserved Ejection Fraction","enrollment":86},{"nctId":"NCT07321223","phase":"NA","title":"Comparison of Different Doses of Vitamin D Supplementation on Glycated Haemoglobin and Blood Glucose Parameters With Type II Diabetes Mellitus Having Vitamin d Deficiency","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Lahore","startDate":"2024-08-22","conditions":"Diabetes (DM), Vitamin D Deficiency","enrollment":108},{"nctId":"NCT02924064","phase":"PHASE3","title":"Efficacy and Safety of Teneligliptin in Combination With Metformin in Chinese Patients With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Tanabe Pharma Corporation","startDate":"2016-09","conditions":"Type 2 Diabetes Mellitus","enrollment":247},{"nctId":"NCT04221750","phase":"PHASE3","title":"Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2021-05-14","conditions":"Frailty, Sarcopenic Obesity, Aging","enrollment":114},{"nctId":"NCT07303127","phase":"NA","title":"Combination of Bitter Melon Extract and Snakehead Fish Powder to Reduce Glycaemia in Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Universitas Muhammadiyah Surakarta","startDate":"2021-06-01","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":80},{"nctId":"NCT06526494","phase":"PHASE2","title":"Metformin and Vascular Function in Prediabetes","status":"WITHDRAWN","sponsor":"Diana Jalal","startDate":"2024-11-13","conditions":"PreDiabetes","enrollment":""},{"nctId":"NCT07302932","phase":"NA","title":"Metformin and Molecular Aging in Prediabetes","status":"COMPLETED","sponsor":"Diabetes Foundation, India","startDate":"2023-02-01","conditions":"Metformin, Prediabetes","enrollment":112},{"nctId":"NCT06297603","phase":"PHASE3","title":"Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2024-03-15","conditions":"Type 2 Diabetes","enrollment":320},{"nctId":"NCT07297290","phase":"PHASE3","title":"Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)","status":"RECRUITING","sponsor":"University Of Nigeria Teaching Hospital","startDate":"2025-07-23","conditions":"Obesity and Cardiovascular Risk, Insulin Resistance, Obesity (Body Mass Index &gt;30 kg/m2)","enrollment":220},{"nctId":"NCT05838573","phase":"PHASE3","title":"Metformin Treatment on Cognitive Impairment of Schizophrenia","status":"RECRUITING","sponsor":"Central South University","startDate":"2023-05-08","conditions":"Schizophrenia","enrollment":120},{"nctId":"NCT06638671","phase":"PHASE4","title":"Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity","status":"RECRUITING","sponsor":"University of Virginia","startDate":"2025-01-31","conditions":"Exercise Capacity, Metformin","enrollment":20},{"nctId":"NCT07057479","phase":"PHASE3","title":"Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2026-09","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":""},{"nctId":"NCT06560333","phase":"PHASE3","title":"iSGLT2 Inhibitor and a iDPP -4 Inhibitor in Treatment of Type 2 Diabetes Mellitus in Patients Treated With Metformin (TRIAD)","status":"WITHDRAWN","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2026-11-30","conditions":"Diabetes Mellitus, Type 2","enrollment":""},{"nctId":"NCT02915198","phase":"PHASE4","title":"Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2023-04-03","conditions":"Prediabetic State, Atherosclerosis, Metformin","enrollment":7410},{"nctId":"NCT06424860","phase":"PHASE1","title":"Fish Oil, Metformin and Heart Health in PCOS","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2025-11-01","conditions":"PCOS, Cardiovascular Disease, Atherosclerotic Cardiovascular Disease","enrollment":146},{"nctId":"NCT05131828","phase":"PHASE2","title":"CCMR Two: A Phase IIa, Randomised, Double-blind, Placebo-controlled Trial of the Ability of the Combination of Metformin and Clemastine to Promote Remyelination in People With Relapsing-remitting Multiple Sclerosis Already on Disease-modifying Therapy","status":"COMPLETED","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2022-03-08","conditions":"Multiple Sclerosis","enrollment":70},{"nctId":"NCT03109847","phase":"PHASE2","title":"Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers","status":"TERMINATED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2017-01-05","conditions":"Thyroid","enrollment":13},{"nctId":"NCT06983223","phase":"NA","title":"Oral Sucrosomial® Vitamin B12 in the Management of B12 Deficiency Among Metformin-Treated Type 2 Diabetes Patients","status":"COMPLETED","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-08-15","conditions":"Vitamin B 12 Deficiency, Type 2 Diabetes Mellitus (T2DM)","enrollment":50},{"nctId":"NCT07272967","phase":"PHASE4","title":"Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury","status":"NOT_YET_RECRUITING","sponsor":"Badr University","startDate":"2026-01-01","conditions":"Spinal Cord Injury (SCI)","enrollment":34},{"nctId":"NCT04670666","phase":"PHASE3","title":"Efficacy and Safety of Madalena Association in the Treatment of Type II Diabetes Mellitus","status":"RECRUITING","sponsor":"EMS","startDate":"2024-11-18","conditions":"Type 2 Diabetes Mellitus","enrollment":270},{"nctId":"NCT06185179","phase":"EARLY_PHASE1","title":"Metformin and Muscle Recovery","status":"RECRUITING","sponsor":"University of Utah","startDate":"2024-09-01","conditions":"Muscle Atrophy or Weakness","enrollment":50},{"nctId":"NCT06393348","phase":"PHASE2","title":"Efficacy and Safety of HRS-7535 Tablets in T2DM Subjects Poorly Controlled With Metformin and SGLT2i.","status":"COMPLETED","sponsor":"Shandong Suncadia Medicine Co., Ltd.","startDate":"2024-05-17","conditions":"Type 2 Diabetes","enrollment":155},{"nctId":"NCT03107884","phase":"EARLY_PHASE1","title":"Role of Metformin on Muscle Health of Older Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Utah","startDate":"2019-08-01","conditions":"Muscle Atrophy, Insulin Resistance","enrollment":64},{"nctId":"NCT06280274","phase":"PHASE4","title":"Metformin Use in Patients Undergoing Total Joint Replacement Surgery","status":"COMPLETED","sponsor":"Oregon Health and Science University","startDate":"2024-06-27","conditions":"Hyperglycemia","enrollment":40},{"nctId":"NCT06323161","phase":"PHASE3","title":"A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2024-03-26","conditions":"Type 2 Diabetes","enrollment":274},{"nctId":"NCT06353347","phase":"PHASE3","title":"Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes Inadequately Controlled With Metformin","status":"COMPLETED","sponsor":"HighTide Biopharma Pty Ltd","startDate":"2023-11-13","conditions":"Type 2 Diabetes Mellitus","enrollment":551},{"nctId":"NCT05532813","phase":"PHASE3","title":"Evaluation of the Efficacy and Safety of Metformin in the Myotonic Dystrophy Type 1 (Steinert's Disease)","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2024-11-29","conditions":"Steinert's Disease, Myotonic Dystrophy 1, Metformin","enrollment":142},{"nctId":"NCT04583462","phase":"PHASE3","title":"Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-06-02","conditions":"Type 1 Diabetes, Peripheral Arterial Calcification","enrollment":230},{"nctId":"NCT06463743","phase":"PHASE2","title":"Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)","status":"RECRUITING","sponsor":"State University of New York at Buffalo","startDate":"2025-09-24","conditions":"Multiple Sclerosis","enrollment":30},{"nctId":"NCT07241897","phase":"PHASE3","title":"DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital of Soochow University","startDate":"2025-12-15","conditions":"Ischemic Stroke, Diabete Mellitus","enrollment":312},{"nctId":"NCT05426044","phase":"PHASE2","title":"Metformin as a Neuroprotective Therapy for Glaucoma","status":"RECRUITING","sponsor":"Christopher Kai Shun Leung","startDate":"2025-06-01","conditions":"Glaucoma","enrollment":125},{"nctId":"NCT06571591","phase":"PHASE3","title":"Efficacy and Safety of Pioglitazone Combination Therapy in Type 2 Diabetes Patients on a Background of Empagliflozin With Metformin","status":"ACTIVE_NOT_RECRUITING","sponsor":"Celltrion","startDate":"2024-08-27","conditions":"T2DM","enrollment":582},{"nctId":"NCT06042855","phase":"PHASE3","title":"ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)","status":"COMPLETED","sponsor":"Susanna Naggie, MD","startDate":"2023-09-05","conditions":"Covid19","enrollment":3214},{"nctId":"NCT04578652","phase":"PHASE3","title":"Fiber and Metformin Combination Therapy in Adolescents With Severe Obesity and Insulin Resistance","status":"RECRUITING","sponsor":"University of Alberta","startDate":"2021-10-22","conditions":"Obesity, Childhood, Insulin Resistance","enrollment":90},{"nctId":"NCT07229534","phase":"PHASE4","title":"Clinical Trial to Evaluate the Efficacy and Safety of DA-5218 in Patients With Type 2 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Dong-A ST Co., Ltd.","startDate":"2025-11","conditions":"Diabete Mellitus","enrollment":238},{"nctId":"NCT04885530","phase":"PHASE3","title":"ACTIV-6: COVID-19 Study of Repurposed Medications","status":"COMPLETED","sponsor":"Susanna Naggie, MD","startDate":"2021-06-08","conditions":"Covid19","enrollment":10956},{"nctId":"NCT06446531","phase":"PHASE1","title":"Prevention of Progression of Prediabetes, Obesity and CV Risk","status":"RECRUITING","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2024-09-11","conditions":"Pre-Diabetes, Weight, Body, Cardiovascular Diseases","enrollment":64},{"nctId":"NCT06100822","phase":"PHASE1","title":"Managing Chronic Tendon Pain by Metformin","status":"RECRUITING","sponsor":"James Wang","startDate":"2024-05-24","conditions":"Tendinopathy, Chronic Pain, Achilles Tendinopathy","enrollment":40},{"nctId":"NCT03229057","phase":"PHASE3","title":"Comparing the Effects of Oral Contraceptive Pills Versus Metformin","status":"COMPLETED","sponsor":"Anuja Dokras","startDate":"2018-01-15","conditions":"PCOS","enrollment":240},{"nctId":"NCT04029480","phase":"PHASE3","title":"Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2019-10-08","conditions":"Type 2 Diabetes Mellitus","enrollment":166},{"nctId":"NCT06109311","phase":"PHASE3","title":"A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 Inhibitor","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2023-11-10","conditions":"Type 2 Diabetes","enrollment":546},{"nctId":"NCT05237960","phase":"PHASE2","title":"Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Arizona","startDate":"2023-01-12","conditions":"Erythroplakia, Oral Leukoplakia","enrollment":34},{"nctId":"NCT07026968","phase":"PHASE3","title":"A Study of Prusogliptin Tablets Combined With Dapagliflozin Tablets and Metformin Hydrochloride Extended Release Tablets in Type 2 Diabetes","status":"ENROLLING_BY_INVITATION","sponsor":"CSPC Ouyi Pharmaceutical Co., Ltd.","startDate":"2025-06-20","conditions":"Type 2 Diabetes","enrollment":815},{"nctId":"NCT05260021","phase":"PHASE3","title":"A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both","status":"COMPLETED","sponsor":"Eli Lilly and Company","startDate":"2022-04-13","conditions":"Type2 Diabetes, Diabetes Mellitus, Diabetes Mellitus, Type 2","enrollment":99},{"nctId":"NCT04826692","phase":"PHASE3","title":"TEsting METformin Against Cognitive Decline in HD","status":"COMPLETED","sponsor":"Instituto de Investigacion Sanitaria La Fe","startDate":"2022-04-11","conditions":"Huntington Disease","enrollment":60},{"nctId":"NCT04121468","phase":"PHASE1, PHASE2","title":"A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple Sclerosis","status":"RECRUITING","sponsor":"The Hospital for Sick Children","startDate":"2020-02-24","conditions":"Multiple Sclerosis (MS)","enrollment":20},{"nctId":"NCT03355469","phase":"PHASE2, PHASE3","title":"Exercise Dose and Metformin for Vascular Health in Metabolic Syndrome","status":"COMPLETED","sponsor":"Rutgers University","startDate":"2017-08-07","conditions":"Metabolic Syndrome","enrollment":91},{"nctId":"NCT03617458","phase":"PHASE2","title":"Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2018-08-23","conditions":"Pulmonary Artery Hypertension","enrollment":73},{"nctId":"NCT06707012","phase":"PHASE4","title":"Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients","status":"RECRUITING","sponsor":"Fazaia Ruth Pfau Medical College","startDate":"2025-10-01","conditions":"Depression","enrollment":140},{"nctId":"NCT07179042","phase":"EARLY_PHASE1","title":"Intertrochanteric Femur Fracture Patients Who Receive Metformin With a Placebo","status":"ENROLLING_BY_INVITATION","sponsor":"University of Utah","startDate":"2025-09-04","conditions":"Intertrochanteric Femur Fracture, Muscle Atrophy","enrollment":60},{"nctId":"NCT07145827","phase":"NA","title":"Effect of Metformin on Endometrial Thickness in Postmenopausal Breast Cancer Patients Receiving Tamoxifen","status":"COMPLETED","sponsor":"Uruk University","startDate":"2024-01-02","conditions":"Breast Cancer, Endometrial Hyperplasia and Endometrial Cancers","enrollment":60},{"nctId":"NCT05132439","phase":"PHASE3","title":"MetfOrmin BenefIts Lower Extremities With Intermittent Claudication","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2022-03-01","conditions":"Intermittent Claudication","enrollment":200},{"nctId":"NCT03054519","phase":"PHASE3","title":"Improve PAD PERformance With METformin","status":"ACTIVE_NOT_RECRUITING","sponsor":"Northwestern University","startDate":"2017-05-23","conditions":"Peripheral Artery Disease","enrollment":203},{"nctId":"NCT07131384","phase":"NA","title":"Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes","status":"NOT_YET_RECRUITING","sponsor":"University of Virginia","startDate":"2025-09-01","conditions":"Males, Females, Sedentary","enrollment":24},{"nctId":"NCT07109700","phase":"PHASE2","title":"A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or Metformin","status":"RECRUITING","sponsor":"Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.","startDate":"2025-04-30","conditions":"Type 2 Diabetes","enrollment":216},{"nctId":"NCT07093476","phase":"PHASE3","title":"Efficacy and Safety of Add-On Therapy With Empagliflozin in Patients With Type 2 Diabetes on a Background of Alogliptin and Metformin","status":"RECRUITING","sponsor":"Celltrion","startDate":"2025-07-18","conditions":"T2DM, Diabete Type 2, DM","enrollment":171},{"nctId":"NCT05243654","phase":"PHASE2","title":"Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy","status":"RECRUITING","sponsor":"Oxford University Clinical Research Unit Indonesia","startDate":"2022-10-01","conditions":"Leprosy, Leprosy, Multibacillary, Neglected Tropical Diseases","enrollment":166},{"nctId":"NCT02570672","phase":"PHASE2","title":"Metformin for Preventing Frailty in High-risk Older Adults","status":"COMPLETED","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2016-04","conditions":"Frailty","enrollment":141},{"nctId":"NCT05744479","phase":"PHASE4","title":"Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability","status":"RECRUITING","sponsor":"Centre for Addiction and Mental Health","startDate":"2023-02-28","conditions":"Intellectual Disability, Developmental Disability, Obesity","enrollment":100},{"nctId":"NCT06649773","phase":"PHASE3","title":"The Experiment of Noiiglutide Injection in Type 2 Diabetes Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2024-10-25","conditions":"Type 2 Diabetes","enrollment":137},{"nctId":"NCT07092618","phase":"PHASE2, PHASE3","title":"Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation","status":"RECRUITING","sponsor":"AgelessRx","startDate":"2024-12-17","conditions":"Longevity, GLP-1, Geroscience","enrollment":150},{"nctId":"NCT06481085","phase":"PHASE2","title":"To Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.","startDate":"2024-06-27","conditions":"Type 2 Diabetes","enrollment":324},{"nctId":"NCT05349474","phase":"EARLY_PHASE1","title":"Metformin Treatment in Progressive Multiple Sclerosis","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2022-04-26","conditions":"Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis","enrollment":23},{"nctId":"NCT07076056","phase":"PHASE3","title":"Clinical Trial to Evaluate the Efficacy and Safety of DW1026C1 or DW1026C2","status":"COMPLETED","sponsor":"Daewon Pharmaceutical Co., Ltd.","startDate":"2022-10-27","conditions":"Type 2 Diabetes","enrollment":230},{"nctId":"NCT06846138","phase":"NA","title":"Enhancing the Efficacy and Tolerability of Metformin by add-on Polyherbal Formulation: a Gut Microbiome Study","status":"ENROLLING_BY_INVITATION","sponsor":"Pauls Stradins Clinical University Hospital","startDate":"2025-03-01","conditions":"Diabetes Mellitus Type 2","enrollment":66},{"nctId":"NCT02040376","phase":"PHASE3","title":"Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2014-06-13","conditions":"Brain Tumor Treated With Cranial or Cranial-Spinal Radiation","enrollment":24},{"nctId":"NCT01825798","phase":"PHASE3","title":"Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD)","status":"COMPLETED","sponsor":"Holland Bloorview Kids Rehabilitation Hospital","startDate":"2013-04","conditions":"Overweight, Autism Spectrum Disorder","enrollment":60},{"nctId":"NCT07065591","phase":"EARLY_PHASE1","title":"Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-10-01","conditions":"Osteoarthritis (OA) of the Knee","enrollment":100},{"nctId":"NCT04767841","phase":"PHASE1, PHASE2","title":"The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Patients With Knee Osteoarthritis","status":"WITHDRAWN","sponsor":"Sadat City University","startDate":"2021-02-16","conditions":"Osteo Arthritis Knee","enrollment":""},{"nctId":"NCT04068246","phase":"PHASE1, PHASE2","title":"The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients","status":"COMPLETED","sponsor":"Sadat City University","startDate":"2019-08-01","conditions":"Rheumatoid Arthritis","enrollment":120},{"nctId":"NCT07055958","phase":"PHASE3","title":"Effect of Metformin as Add-on Therapy in Levodopa Treated Parkinson's Disease Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2024-12-29","conditions":"Parkinson Disease","enrollment":74},{"nctId":"NCT07057271","phase":"PHASE3","title":"A Study of CJC-1134-PC Injection in Patients With Type 2 Diabetes With Inadequately Controlled Blood Glucose Level After Metformin Monotherapy or Metformin in Combination With Insulin Secretagogues","status":"COMPLETED","sponsor":"Changshan ConjuChem BioPharmaceutical Research and Development (Hebei) Co., Ltd.","startDate":"2021-05-27","conditions":"Type 2 Diabetes Mellitus - Poor Control","enrollment":464}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":119,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Placebo-Metformin","genericName":"Placebo-Metformin","companyName":"Steno Diabetes Center Copenhagen","companyId":"steno-diabetes-center-copenhagen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metformin reduces hepatic glucose production and improves insulin sensitivity, thereby lowering blood glucose levels in type 2 diabetes. Used for Type 2 diabetes mellitus.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}