{"id":"placebo-matching-dmf","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL555694","moleculeType":"Small molecule","molecularWeight":"661.66"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Placebo matching DMF serves as an inert control in Phase 3 trials to maintain blinding while mimicking the physical and sensory properties of the active DMF drug. DMF itself is an immunomodulator that activates the Nrf2 pathway and reduces pro-inflammatory cytokines; the placebo allows researchers to isolate the true therapeutic effect of DMF from placebo response in multiple sclerosis studies.","oneSentence":"This is a placebo formulation designed to match the appearance and administration characteristics of dimethyl fumarate (DMF) for blinded clinical trial purposes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:27:51.392Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsing-remitting multiple sclerosis (as control in Phase 3 trials)"}]},"trialDetails":[{"nctId":"NCT07483632","phase":"PHASE3","title":"A Study to Learn About the Safety of Diroximel Fumarate (DRF) and Dimethyl Fumarate (DMF) and Their Effects on Relapses in Pediatric Participants With Relapsing Forms of Multiple Sclerosis (RMS)","status":"NOT_YET_RECRUITING","sponsor":"Biogen","startDate":"2026-11-16","conditions":"Relapsing Forms of Multiple Sclerosis","enrollment":185},{"nctId":"NCT07258394","phase":"PHASE3","title":"Clinical Study for Dimethyl Fumarate in Preserving Islet β-Cell Function in Type 1 Diabetes Mellitus","status":"RECRUITING","sponsor":"Nanjing Medical University","startDate":"2026-01-27","conditions":"Type 1 Diabetes","enrollment":90},{"nctId":"NCT02975349","phase":"PHASE2","title":"A Study of Efficacy and Safety of M2951 in Participants With Relapsing Multiple Sclerosis","status":"TERMINATED","sponsor":"EMD Serono Research & Development Institute, Inc.","startDate":"2017-03-07","conditions":"Relapsing-remitting Multiple Sclerosis","enrollment":267},{"nctId":"NCT01281111","phase":"PHASE1","title":"Alternate Dosing Regimens of BG00012 in Healthy Volunteers","status":"COMPLETED","sponsor":"Biogen","startDate":"2011-02-01","conditions":"Healthy","enrollment":56},{"nctId":"NCT02907177","phase":"PHASE3","title":"Clinical Study to Compare the Efficacy and Safety of Ponesimod to Placebo in Subjects With Active Relapsing Multiple Sclerosis Who Are Treated With Dimethyl Fumarate (Tecfidera®)","status":"TERMINATED","sponsor":"Actelion","startDate":"2017-03-30","conditions":"Multiple Sclerosis","enrollment":136},{"nctId":"NCT02410278","phase":"PHASE4","title":"Study of Montelukast on Gastrointestinal Tolerability in Patients With Relapsing Forms of Multiple Sclerosis Receiving Tecfidera","status":"COMPLETED","sponsor":"Biogen","startDate":"2015-03-12","conditions":"Multiple Sclerosis","enrollment":102},{"nctId":"NCT01838668","phase":"PHASE3","title":"An Efficacy and Safety Study of BG00012 (Dimethyl Fumarate) in Asian Subjects With Relapsing Remitting Multiple Sclerosis (RRMS)","status":"COMPLETED","sponsor":"Biogen","startDate":"2013-03-28","conditions":"Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis","enrollment":225},{"nctId":"NCT02430532","phase":"PHASE3","title":"BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis","status":"TERMINATED","sponsor":"Biogen","startDate":"2015-05","conditions":"Multiple Sclerosis, Secondary Progressive","enrollment":58},{"nctId":"NCT02090413","phase":"PHASE4","title":"Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitting Multiple Sclerosis","status":"COMPLETED","sponsor":"Biogen","startDate":"2014-05","conditions":"Relapsing-Remitting Multiple Sclerosis","enrollment":241},{"nctId":"NCT01815723","phase":"PHASE3","title":"Efficacy Study on Dimethyl Fumarate to Treat Moderate to Severe Plaque Psoriasis","status":"WITHDRAWN","sponsor":"Forward-Pharma GmbH","startDate":"2016-06","conditions":"Plaque Psoriasis","enrollment":""},{"nctId":"NCT01568112","phase":"PHASE3","title":"Effect of Aspirin Pretreatment or Slow Dose Titration on Flushing and Gastrointestinal Events in Healthy Volunteers Receiving Delayed-release Dimethyl Fumarate","status":"COMPLETED","sponsor":"Biogen","startDate":"2012-04","conditions":"Healthy","enrollment":173},{"nctId":"NCT02428218","phase":"PHASE3","title":"Placebo-Controlled Study of the Efficacy and Safety of BG00012 in Pediatric Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS)","status":"WITHDRAWN","sponsor":"Biogen","startDate":"2016-05","conditions":"Relapsing-Remitting Multiple Sclerosis, Relapsing Forms of Multiple Sclerosis","enrollment":""},{"nctId":"NCT01915901","phase":"PHASE1","title":"PeptoBismol® Use to Reduce Gastrointestinal Events in Healthy Volunteers Receiving DMF [Tecfidera®] Twice Daily","status":"COMPLETED","sponsor":"Biogen","startDate":"2013-08","conditions":"Healthy","enrollment":175}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Placebo matching DMF","genericName":"Placebo matching DMF","companyName":"Biogen","companyId":"biogen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a placebo formulation designed to match the appearance and administration characteristics of dimethyl fumarate (DMF) for blinded clinical trial purposes. Used for Relapsing-remitting multiple sclerosis (as control in Phase 3 trials).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}