{"id":"placebo-lead-in","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL1909062","moleculeType":"Small molecule","molecularWeight":"325.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"A placebo lead-in period is a methodological approach in clinical trials where all enrolled patients initially receive placebo for a defined duration. This allows researchers to measure natural disease progression, establish stable baseline measurements, and identify patients with high placebo response rates who may be excluded from the main randomized phase. This design strengthens the ability to detect true drug effects by reducing noise from placebo responders.","oneSentence":"Placebo lead-in is a study design phase where patients receive placebo before randomization to active treatment, used to establish baseline disease progression and identify placebo responders.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:27:51.783Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[]},"trialDetails":[{"nctId":"NCT06119581","phase":"PHASE3","title":"A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2023-12-21","conditions":"Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis","enrollment":1264},{"nctId":"NCT07236190","phase":"PHASE1, PHASE2","title":"Biomarker-based Trial of NPC-1 for Alzheimer's Pathology","status":"NOT_YET_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2026-03","conditions":"Alzheimer Disease, Mild Cognitive Impairment (MCI), Subjective Cognitive Complaints (SCCs)","enrollment":40},{"nctId":"NCT03997786","phase":"PHASE2, PHASE3","title":"A Study of Tildrakizumab in Pediatric Subjects With Chronic Plaque Psoriasis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sun Pharmaceutical Industries Limited","startDate":"2020-01-15","conditions":"Moderate-to-severe Chronic Plaque Psoriasis","enrollment":135},{"nctId":"NCT07218380","phase":"PHASE3","title":"A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract","status":"RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2025-12-12","conditions":"Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Neoplasm Metastasis","enrollment":450},{"nctId":"NCT05359861","phase":"PHASE2","title":"Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma","status":"COMPLETED","sponsor":"Coherus Oncology, Inc.","startDate":"2022-04-12","conditions":"Hepatocellular Carcinoma","enrollment":30},{"nctId":"NCT07310901","phase":"PHASE1","title":"A 2-part, Phase 1b Clinical Study Designed to Evaluate the Safety, PK, and Efficacy of CRB-913 in Participants With Obesity","status":"RECRUITING","sponsor":"Corbus Pharmaceuticals Inc.","startDate":"2025-12-04","conditions":"Obese But Otherwise Healthy Participants","enrollment":252},{"nctId":"NCT04150068","phase":"PHASE2, PHASE3","title":"Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With an Optimized Background Regimen (OBR) in Heavily Treatment Experienced Participants Living With HIV-1 Infection With Multidrug Resistance","status":"ACTIVE_NOT_RECRUITING","sponsor":"Gilead Sciences","startDate":"2019-11-21","conditions":"HIV-1-infection","enrollment":72},{"nctId":"NCT05772546","phase":"PHASE2","title":"Avatrombopag vs. Placebo for CIT in GI Malignancies","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hanny Al-Samkari, MD","startDate":"2023-11-01","conditions":"Gastrointestinal Cancer, Gastrointestinal Neoplasms, Chemotherapy-Induced Thrombocytopenia","enrollment":60},{"nctId":"NCT06334133","phase":"PHASE3","title":"Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes","status":"RECRUITING","sponsor":"vTv Therapeutics","startDate":"2024-06-14","conditions":"Diabetes Mellitus, Type 1","enrollment":150},{"nctId":"NCT05342519","phase":"PHASE2","title":"Daily Topical Rapamycin for Vitiligo","status":"ACTIVE_NOT_RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2022-07-28","conditions":"Vitiligo","enrollment":20},{"nctId":"NCT06594068","phase":"PHASE4","title":"Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users","status":"RECRUITING","sponsor":"AstraZeneca","startDate":"2026-01-16","conditions":"Systemic Lupus Erythematosus","enrollment":16},{"nctId":"NCT05649722","phase":"PHASE2, PHASE3","title":"An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Insmed Incorporated","startDate":"2023-05-11","conditions":"Pulmonary Hypertension, Interstitial Lung Disease","enrollment":31},{"nctId":"NCT05649748","phase":"PHASE2, PHASE3","title":"An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Arterial Hypertension (PAH)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Insmed Incorporated","startDate":"2023-03-07","conditions":"Pulmonary Arterial Hypertension","enrollment":91},{"nctId":"NCT01517945","phase":"","title":"Attention and Interpretation Modification (AIM) for Fear of Cancer Recurrence: An Intervention Development Study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"2012-01","conditions":"Breast Cancer, Rare Cancer","enrollment":252},{"nctId":"NCT05440422","phase":"PHASE2","title":"The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD","status":"RECRUITING","sponsor":"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","startDate":"2023-12-07","conditions":"Systemic Lupus Erythematosus, Cardiovascular Disease, Premature Atherosclerosis","enrollment":45},{"nctId":"NCT05212129","phase":"NA","title":"Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome","status":"RECRUITING","sponsor":"Medical College of Wisconsin","startDate":"2021-04-05","conditions":"Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome","enrollment":90},{"nctId":"NCT07405021","phase":"NA","title":"Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01-01","conditions":"Transcutaneous Vagal Nerve Stimulation (tVNS), Diabetic Polyneuropathy","enrollment":40},{"nctId":"NCT04183205","phase":"PHASE4","title":"Predicting SSRI Efficacy in Veterans With PTSD","status":"TERMINATED","sponsor":"VA Office of Research and Development","startDate":"2019-09-11","conditions":"Posttraumatic Stress Disorder, Major Depressive Disorder","enrollment":26},{"nctId":"NCT06983730","phase":"EARLY_PHASE1","title":"The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response","status":"RECRUITING","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2026-01-26","conditions":"Heat Strain, Healthy Volunteer Study, Kidney Dysfunction","enrollment":28},{"nctId":"NCT04259619","phase":"NA","title":"Low-Level Laser Therapy (LLLT) Treatment for Breast-Feeding Women With Painful Nipple Lesions","status":"TERMINATED","sponsor":"University of Zurich","startDate":"2020-03-02","conditions":"Nipple Lesions","enrollment":96},{"nctId":"NCT04666636","phase":"PHASE2","title":"Mechanisms for Activation of Beige Adipose Tissue in Humans","status":"RECRUITING","sponsor":"Philip Kern","startDate":"2020-12-07","conditions":"PreDiabetes","enrollment":65},{"nctId":"NCT05417789","phase":"PHASE3","title":"Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)","status":"ACTIVE_NOT_RECRUITING","sponsor":"SynOx Therapeutics Limited","startDate":"2024-10-09","conditions":"TGCT","enrollment":128},{"nctId":"NCT04217174","phase":"NA","title":"An Avatar-based Mobile Phone Intervention to Promote Health in African American MSM","status":"COMPLETED","sponsor":"University of Illinois at Chicago","startDate":"2020-03-04","conditions":"Medication Adherence, Retention in Care","enrollment":315},{"nctId":"NCT06933706","phase":"PHASE2","title":"Losartan to Improve Outcomes After Multi-ligament Knee Injury","status":"RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2025-10-01","conditions":"Multi-ligament Knee Injury","enrollment":90},{"nctId":"NCT06495684","phase":"NA","title":"Effects of Multiple-Session Transcranial Direct Current Stimulation (tDCS) on Behavioral, Physiological, and Electrophysiological Measures With Adults With Autism Spectrum Disorder (ASD)","status":"RECRUITING","sponsor":"University of New Mexico","startDate":"2024-03-12","conditions":"Autism Spectrum Disorder, Autism or Autistic Traits","enrollment":20},{"nctId":"NCT03799562","phase":"PHASE2","title":"Neurosteroids for PTSD in Veterans","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2019-05-01","conditions":"Posttraumatic Stress Disorder","enrollment":96},{"nctId":"NCT05251259","phase":"PHASE2","title":"Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-Severe Uncontrolled Asthma","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2022-01-27","conditions":"Asthma","enrollment":670},{"nctId":"NCT07060534","phase":"NA","title":"Building Healthy Eating and Self-Esteem Together for University Students","status":"RECRUITING","sponsor":"University of Kansas","startDate":"2026-06-23","conditions":"Eating Disorders (Excluding Anorexia Nervosa), Binge-Eating Disorder","enrollment":74},{"nctId":"NCT05832229","phase":"PHASE2","title":"Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States","status":"RECRUITING","sponsor":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","startDate":"2023-12-07","conditions":"Cirrhosis, Cirrhosis, Liver, Cirrhosis Early","enrollment":256},{"nctId":"NCT03654053","phase":"PHASE3","title":"Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis","status":"ACTIVE_NOT_RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2020-10-02","conditions":"Cirrhosis","enrollment":142},{"nctId":"NCT04897776","phase":"NA","title":"Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy","status":"COMPLETED","sponsor":"Yale University","startDate":"2021-10-31","conditions":"Epilepsy, Temporal Lobe","enrollment":5},{"nctId":"NCT06824064","phase":"PHASE2","title":"Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer","status":"RECRUITING","sponsor":"Riboscience, LLC.","startDate":"2025-01-17","conditions":"Metastatic Colorectal Cancer, Advanced Colorectal Cancer","enrollment":150},{"nctId":"NCT07246889","phase":"PHASE3","title":"Study of AHB-137 in Participants With Chronic Hepatitis B (CHB) Treated With Nucleos(t)Ide Analogues (NAs)(AUSHINE)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ausper Biopharma Co., Ltd.","startDate":"2025-08-12","conditions":"Chronic Hepatitis B","enrollment":577},{"nctId":"NCT00792168","phase":"PHASE4","title":"Physiologic Monitoring of Antidepressant Response","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"1996-11","conditions":"Major Depression","enrollment":38},{"nctId":"NCT07281404","phase":"EARLY_PHASE1","title":"FIH Lead-in Study of YASO GEL Followed by a Phase 1 Randomized, Double-blind Study to Assess Safety and Pharmacokinetics of YASO GEL","status":"NOT_YET_RECRUITING","sponsor":"Yaso Therapeutics Corporation","startDate":"2026-04","conditions":"Early-phase Safety and PK Study of a Vaginal Gel","enrollment":72},{"nctId":"NCT04100057","phase":"NA","title":"Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia","status":"RECRUITING","sponsor":"Stanford University","startDate":"2021-08-31","conditions":"Alzheimer Disease, Mild Cognitive Impairment, Neuropsychiatric Symptoms","enrollment":150},{"nctId":"NCT06648759","phase":"NA","title":"Vagal Stimulator to Reduce Nasogastric Tube Use","status":"RECRUITING","sponsor":"Jacques E. Chelly","startDate":"2024-12-04","conditions":"Nasogastric Tube Intubation","enrollment":60},{"nctId":"NCT05632627","phase":"PHASE2","title":"Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2023-04-11","conditions":"Brain Injuries, Traumatic","enrollment":43},{"nctId":"NCT06109909","phase":"NA","title":"Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2024-01-01","conditions":"Mild Traumatic Brain Injury, Photophobia","enrollment":36},{"nctId":"NCT05111626","phase":"PHASE3","title":"Bemarituzumab Plus Chemotherapy and Nivolumab Versus Chemotherapy and Nivolumab for FGFR2b Overexpressed Untreated Advanced Gastric and Gastroesophageal Junction Cancer.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Amgen","startDate":"2022-03-14","conditions":"Gastric Cancer, Gastroesophageal Junction Adenocarcinoma","enrollment":515},{"nctId":"NCT05299944","phase":"PHASE2","title":"Reducing Pain and Opioid Use With CBD","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2022-03-08","conditions":"Opioid Use Disorder","enrollment":126},{"nctId":"NCT04873037","phase":"NA","title":"BTL Emsella Chair Versus Sham for the Treatment of Overactive Bladder","status":"RECRUITING","sponsor":"Corewell Health East","startDate":"2021-11-22","conditions":"Overactive Bladder Syndrome, Overactive Bladder, Urinary Frequency","enrollment":166},{"nctId":"NCT04133675","phase":"NA","title":"BTL Emsella Chair Versus Sham for the Treatment of Stress Urinary Incontinence","status":"RECRUITING","sponsor":"Corewell Health East","startDate":"2019-12-18","conditions":"Stress Urinary Incontinence","enrollment":110},{"nctId":"NCT07268846","phase":"NA","title":"Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery","status":"RECRUITING","sponsor":"AC Camargo Cancer Center","startDate":"2025-06-01","conditions":"Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)","enrollment":164},{"nctId":"NCT07254663","phase":"","title":"GEL & MEDication Dysphagia","status":"RECRUITING","sponsor":"Heinrich-Heine University, Duesseldorf","startDate":"2025-09-15","conditions":"Neurological Diseases or Conditions, Healthy Participants","enrollment":500},{"nctId":"NCT05179343","phase":"NA","title":"SCRATCH-HTN Study: Evaluating Autonomic Neuromodulation Using Trans-cutaneous Vagal Stimulation in Hypertensive Patients","status":"COMPLETED","sponsor":"Queen Mary University of London","startDate":"2022-08-01","conditions":"Uncontrolled Hypertension, High Blood Pressure","enrollment":63},{"nctId":"NCT04713657","phase":"PHASE1","title":"Beta-blocker Administration for Cardiomyocyte Division","status":"RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2022-12-16","conditions":"Tetralogy of Fallot, Double Outlet Right Ventricle","enrollment":40},{"nctId":"NCT07234032","phase":"PHASE3","title":"An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)","status":"NOT_YET_RECRUITING","sponsor":"Insmed Incorporated","startDate":"2026-04-01","conditions":"Pulmonary Hypertension, Interstitial Lung Disease","enrollment":344},{"nctId":"NCT06100185","phase":"NA","title":"Wearable Transcranial Electrical Stimulation (tES) for Insomnia","status":"RECRUITING","sponsor":"Uniformed Services University of the Health Sciences","startDate":"2023-10-25","conditions":"Insomnia","enrollment":100},{"nctId":"NCT04541589","phase":"PHASE2","title":"Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome","status":"COMPLETED","sponsor":"Novartis Pharmaceuticals","startDate":"2021-01-05","conditions":"Sjogren's Syndrome","enrollment":206},{"nctId":"NCT04825223","phase":"PHASE1","title":"Study of a Novel Multicomponent Meningococcal Group B Vaccine When Given Alone or With Other Licensed Vaccines in Adults, Adolescents, Toddlers and Infants","status":"TERMINATED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2021-03-29","conditions":"Meningococcal Immunisation, Healthy Volunteers","enrollment":576},{"nctId":"NCT06665165","phase":"PHASE1","title":"AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis","status":"RECRUITING","sponsor":"Amylyx Pharmaceuticals Inc.","startDate":"2025-04-07","conditions":"ALS","enrollment":48},{"nctId":"NCT06824649","phase":"PHASE4","title":"Biologics in Chronic Rhinosinusitis With Nasal Polyposis","status":"NOT_YET_RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2026-03","conditions":"Chronic Sinusitis, Nasal Polyps","enrollment":504},{"nctId":"NCT03913845","phase":"PHASE4","title":"The Impact of Retropubic Lidocaine vs Saline on Postoperative Urinary Retention Following Midurethral Sling","status":"COMPLETED","sponsor":"West Penn Allegheny Health System","startDate":"2019-11-25","conditions":"Stress Urinary Incontinence","enrollment":150},{"nctId":"NCT07189390","phase":"PHASE2","title":"The Bloom Infant Probiotic (BIP) Study","status":"NOT_YET_RECRUITING","sponsor":"South Australian Health and Medical Research Institute","startDate":"2025-10","conditions":"Infant, Newborn, Immunity, Immunisation","enrollment":360},{"nctId":"NCT00532155","phase":"PHASE3","title":"A Study of Aflibercept Versus Placebo in Patients With Second-Line Docetaxel for Locally Advanced or Metastatic Non-Small-Cell Lung Cancer","status":"COMPLETED","sponsor":"Sanofi","startDate":"2007-09","conditions":"Carcinoma, Non Small Cell Lung","enrollment":913},{"nctId":"NCT03815019","phase":"PHASE4","title":"iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children","status":"COMPLETED","sponsor":"University of Kansas Medical Center","startDate":"2019-08-15","conditions":"Feeding Behavior, Feeding Disorder of Infancy or Early Childhood","enrollment":70},{"nctId":"NCT07163130","phase":"NA","title":"Tragus Stimulation for POTS Treatment","status":"NOT_YET_RECRUITING","sponsor":"Aristotle University Of Thessaloniki","startDate":"2025-09-01","conditions":"Postural Orthostatic Tachycardia Syndrome (POTS)","enrollment":24},{"nctId":"NCT05009836","phase":"PHASE3","title":"Clinical Study on Savolitinib + Osimertinib in Treatment of EGFRm+/MET+ Locally Advanced or Metastatic NSCLC","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hutchison Medipharma Limited","startDate":"2021-09-06","conditions":"Non-small Cell Lung Cancer","enrollment":320},{"nctId":"NCT04607850","phase":"PHASE1, PHASE2","title":"Prime-boost Vaccine Study in Women With Low-grade Cervical HPV Lesions","status":"COMPLETED","sponsor":"Barinthus Biotherapeutics","startDate":"2021-03-16","conditions":"HPV Infection, CIN1","enrollment":108},{"nctId":"NCT04341948","phase":"NA","title":"Treatment of Post-Operative Pain Following Orthopedic Surgery With SPRINT® Peripheral Nerve Stimulation (PNS) System","status":"COMPLETED","sponsor":"SPR Therapeutics, Inc.","startDate":"2020-08-06","conditions":"Postoperative Pain, Total Knee Replacement, Total Knee Arthroplasty","enrollment":56},{"nctId":"NCT07021495","phase":"","title":"SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)","status":"RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2025-07-29","conditions":"Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO)","enrollment":840},{"nctId":"NCT04131829","phase":"PHASE1, PHASE2","title":"Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD","status":"RECRUITING","sponsor":"Yale University","startDate":"2019-10-14","conditions":"Obsessive-Compulsive Disorder","enrollment":100},{"nctId":"NCT06558409","phase":"NA","title":"Safer Still (Exploratory Project 3)","status":"RECRUITING","sponsor":"Jeff Bridge","startDate":"2024-11-07","conditions":"Suicide Prevention","enrollment":80},{"nctId":"NCT05747534","phase":"PHASE2","title":"AT1001 for the Treatment of Long COVID","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2023-05-31","conditions":"Long COVID, Long COVID-19, Post Acute COVID-19 Syndrome","enrollment":150},{"nctId":"NCT07083882","phase":"PHASE2","title":"Faecal Autologous Capsule Transplantation for Type 1 Diabetes Mellitus","status":"RECRUITING","sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","startDate":"2025-09","conditions":"Type 1 Diabetes Mellitis, Type 1 Diabetes (T1D), Fecal Microbiota Therapy (FMT)","enrollment":110},{"nctId":"NCT06849466","phase":"PHASE4","title":"Effect of Perioperative Dexmedetomidine on Chronic Post-Surgical Pain","status":"ENROLLING_BY_INVITATION","sponsor":"Peking Union Medical College Hospital","startDate":"2025-07-01","conditions":"Chronic Post-Surgical Pain","enrollment":364},{"nctId":"NCT04880876","phase":"PHASE3","title":"A Study Evaluating Oral Eluxadoline Administered to Pediatric Participants With Irritable Bowel Syndrome With Diarrhea (IBS-D)","status":"ENROLLING_BY_INVITATION","sponsor":"AbbVie","startDate":"2021-08-13","conditions":"Irritable Bowel Syndrome","enrollment":124},{"nctId":"NCT05424003","phase":"PHASE2","title":"Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant","status":"RECRUITING","sponsor":"Virginia Commonwealth University","startDate":"2024-02-22","conditions":"NAFLD","enrollment":50},{"nctId":"NCT04870333","phase":"PHASE2, PHASE3","title":"PROphylaxis for paTiEnts at Risk of COVID-19 infecTion -V","status":"COMPLETED","sponsor":"Cambridge University Hospitals NHS Foundation Trust","startDate":"2021-02-19","conditions":"Covid19","enrollment":2240},{"nctId":"NCT06422767","phase":"PHASE1","title":"Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2024-07-18","conditions":"Hepatitis B","enrollment":46},{"nctId":"NCT01689740","phase":"PHASE2","title":"Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSD","status":"COMPLETED","sponsor":"Lykos Therapeutics","startDate":"2013-01-17","conditions":"Posttraumatic Stress Disorder (PTSD)","enrollment":10},{"nctId":"NCT06606561","phase":"PHASE1, PHASE2","title":"NANOVAE to Treat Knee Osteoarthritis (KOA)","status":"NOT_YET_RECRUITING","sponsor":"Nova Vita Laboratory","startDate":"2025-10-01","conditions":"Knee Osteoarthritis","enrollment":24},{"nctId":"NCT04886154","phase":"PHASE1, PHASE2","title":"A Study on the Safety, Effectiveness and Immune Response of Meningococcal Combined ABCWY Vaccine in Healthy Adolescents and Adults","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2021-06-14","conditions":"Infections, Meningococcal","enrollment":1440},{"nctId":"NCT04464564","phase":"PHASE3","title":"Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type","status":"TERMINATED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2020-09-11","conditions":"Agitation in Patients With Dementia of the Alzheimer's Type","enrollment":241},{"nctId":"NCT04408755","phase":"PHASE3","title":"Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type","status":"TERMINATED","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2020-07-13","conditions":"Agitation in Patients With Dementia of the Alzheimer's Type","enrollment":184},{"nctId":"NCT06316583","phase":"NA","title":"Clinical Study on Dry Needling for Primary Dysmenorrhea and Its Preliminary Correlation With Acupoints","status":"RECRUITING","sponsor":"Beijing Hospital","startDate":"2024-04-01","conditions":"Trigger Point Pain, Myofascial, Acupuncture, Primary Dysmenorrhea","enrollment":150},{"nctId":"NCT06974890","phase":"NA","title":"Effects of Shuttle Balance Training on Balance , Gait and Postural Control in Children With Mild Cognitive Impairment","status":"RECRUITING","sponsor":"Riphah International University","startDate":"2025-04-15","conditions":"Mild Cognitive Impairment","enrollment":24},{"nctId":"NCT06941155","phase":"NA","title":"Gamified Combined Cognitive Bias Modification in Adults Diagnosed With OCD: Randomized Controlled Trial","status":"RECRUITING","sponsor":"Dokuz Eylul University","startDate":"2025-05-14","conditions":"Obsessive Compulsive Disorder (OCD)","enrollment":90},{"nctId":"NCT06075914","phase":"NA","title":"Ketone Conferred Resiliency Against Sleep Restriction With Nutritional Intervention.","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2023-05-01","conditions":"Sleep Deprivation, Nutritional Intervention","enrollment":60},{"nctId":"NCT04420221","phase":"PHASE2","title":"Safety, Immunogenicity and Efficacy of GSK S. Aureus Candidate Vaccine (GSK3878858A) When Administered to Healthy Adults (Dose-escalation) and to Adults 18 to 64 Years of Age With a Recent S. Aureus Skin and Soft Tissue Infection (SSTI)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2022-11-16","conditions":"Infections, Soft Tissue","enrollment":226},{"nctId":"NCT04432883","phase":"NA","title":"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","status":"RECRUITING","sponsor":"University of New Mexico","startDate":"2022-10-18","conditions":"Stroke, Aphasia","enrollment":50},{"nctId":"NCT02498392","phase":"PHASE2","title":"An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2015-10-07","conditions":"Depressive Disorder, Anxiety","enrollment":161},{"nctId":"NCT03559192","phase":"PHASE2","title":"A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2018-07-16","conditions":"Depressive Disorder, Major","enrollment":181},{"nctId":"NCT03374475","phase":"PHASE1","title":"A Study to Investigate the Antidepressant Mechanism-of-action of JNJ-42847922 in Participants With Major Depressive Disorder","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2018-01-05","conditions":"Depressive Disorder, Major","enrollment":140},{"nctId":"NCT03952559","phase":"PHASE3","title":"A Study of Baricitinib (LY3009104) in Children and Adolescents With Atopic Dermatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Eli Lilly and Company","startDate":"2019-05-24","conditions":"Atopic Dermatitis","enrollment":516},{"nctId":"NCT06078748","phase":"NA","title":"The Lifestyle Exercise and Diet Trial (LEAD) 2.0","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Waterloo","startDate":"2023-10-03","conditions":"Subjective Cognitive Decline","enrollment":140},{"nctId":"NCT05201144","phase":"PHASE2","title":"A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)","status":"RECRUITING","sponsor":"University of Utah","startDate":"2022-09-15","conditions":"Congenital Diaphragmatic Hernia, Pulmonary Hypertension","enrollment":40},{"nctId":"NCT04536870","phase":"NA","title":"Statins in Reducing Events in the Elderly (STAREE) Heart Sub-study","status":"ACTIVE_NOT_RECRUITING","sponsor":"Monash University","startDate":"2019-12-12","conditions":"Heart Failure, Atrial Fibrillation, Healthy Ageing","enrollment":369},{"nctId":"NCT05672134","phase":"PHASE2","title":"Evaluation of GeranylGeranylAcetone in Heart Failure With Preserved Ejection Fraction","status":"COMPLETED","sponsor":"Amsterdam UMC, location VUmc","startDate":"2023-04-26","conditions":"Heart Failure With Preserved Ejection Fraction","enrollment":43},{"nctId":"NCT06390137","phase":"NA","title":"Anti-Inflammatory Effects Of Frequency Specific Microcurrent (FSM) In Osteoarthritic Adults","status":"COMPLETED","sponsor":"Nova Southeastern University","startDate":"2025-03-05","conditions":"Osteoarthritis","enrollment":10},{"nctId":"NCT06892951","phase":"PHASE1, PHASE2","title":"CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Tours","startDate":"2025-06","conditions":"Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections","enrollment":100},{"nctId":"NCT02641639","phase":"PHASE2, PHASE3","title":"FOCUS: PCC + Bevacizumab + CA4P Versus PCC + Bevacizumab + Placebo for Subjects With Platinum Resistant Ovarian Cancer","status":"TERMINATED","sponsor":"Mateon Therapeutics","startDate":"2016-06","conditions":"Platinum Resistant Ovarian Cancer","enrollment":70},{"nctId":"NCT05469347","phase":"PHASE1","title":"Alirocumab in Patients with Sepsis","status":"COMPLETED","sponsor":"Jonathan Sevransky","startDate":"2023-01-04","conditions":"Sepsis","enrollment":50},{"nctId":"NCT03520790","phase":"PHASE1","title":"Paricalcitol Plus Gemcitabine and Nab-paclitaxel in Metastatic Pancreatic Cancer","status":"TERMINATED","sponsor":"Dana-Farber Cancer Institute","startDate":"2018-12-05","conditions":"Pancreatic Cancer","enrollment":36},{"nctId":"NCT05329090","phase":"PHASE3","title":"Evaluation of Glucocorticoids Plus Rituximab in Patients with Newly-Diagnosed or Relapsing IgA Vasculitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Hopital Foch","startDate":"2022-03-11","conditions":"IgA Vasculitis","enrollment":75},{"nctId":"NCT05590403","phase":"PHASE3","title":"A Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 50-59 Years of Age, Including Adults at Increased Risk of Respiratory Syncytial Virus Lower Respiratory Tract Disease, Compared to Older Adults 60 Years of Age and Above","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2022-10-28","conditions":"Respiratory Syncytial Virus Infections","enrollment":1544},{"nctId":"NCT06835777","phase":"NA","title":"Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper","status":"NOT_YET_RECRUITING","sponsor":"Canterbury Christ Church University","startDate":"2025-03-01","conditions":"Placebo Effect, Nocebo Effect","enrollment":56},{"nctId":"NCT04709419","phase":"NA","title":"Celliant Socks to Increase Tissue Oxygenation and Complete Wound Closure in Diabetic Foot Wounds","status":"TERMINATED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2022-07-28","conditions":"Diabetic Foot Ulcer","enrollment":4},{"nctId":"NCT05747794","phase":"PHASE2, PHASE3","title":"Study in Metastatic Breast Cancer Patients Receiving Eftilagimod Alpha or Placebo in Combination with Paclitaxel Chemotherapy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Immutep S.A.S.","startDate":"2023-05-22","conditions":"Breast Carcinoma","enrollment":849}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":287,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Placebo lead in","genericName":"Placebo lead in","companyName":"Technische Universität Dresden","companyId":"technische-universit-t-dresden","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}