{"id":"placebo-for-midazolam","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Placebos are inert substances used as controls in clinical trials. Any observed effects result from patient expectation, the therapeutic context, and natural disease progression rather than direct drug action. In this case, it serves as a control comparator for midazolam, a benzodiazepine anxiolytic and sedative.","oneSentence":"A placebo has no active pharmacological mechanism; it produces therapeutic effects through psychological and psychophysiological processes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:00:54.810Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Control arm in midazolam clinical trials"}]},"trialDetails":[{"nctId":"NCT05528718","phase":"","title":"SMILE Trial - Imaging Sub-Study","status":"COMPLETED","sponsor":"Unity Health Toronto","startDate":"2023-03-07","conditions":"Major Depressive Disorder","enrollment":11},{"nctId":"NCT06154447","phase":"PHASE1","title":"Evaluation of VX-828 in Healthy Participants and in Participants With Cystic Fibrosis","status":"RECRUITING","sponsor":"Vertex Pharmaceuticals Incorporated","startDate":"2023-12-12","conditions":"Cystic Fibrosis","enrollment":255},{"nctId":"NCT07184801","phase":"PHASE3","title":"Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy","status":"RECRUITING","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2025-10-01","conditions":"Medical Thoracoscopy","enrollment":56},{"nctId":"NCT07227454","phase":"PHASE3","title":"A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder","status":"RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2026-01-08","conditions":"Depressive Disorder, Major","enrollment":258},{"nctId":"NCT06608277","phase":"PHASE2","title":"Ketamine, SGB and Combination Treatment for TBI","status":"RECRUITING","sponsor":"Northwestern University","startDate":"2025-07-02","conditions":"Posttraumatic Headache, Posttraumatic Stress Disorder","enrollment":175},{"nctId":"NCT06566794","phase":"NA","title":"KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism","status":"COMPLETED","sponsor":"Helsinki University Central Hospital","startDate":"2024-08-22","conditions":"Drug Interaction","enrollment":12},{"nctId":"NCT03016819","phase":"PHASE3","title":"Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)","status":"RECRUITING","sponsor":"Advenchen Laboratories, LLC","startDate":"2017-08-15","conditions":"Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma","enrollment":325},{"nctId":"NCT07289776","phase":"PHASE1","title":"A First-in-human Trial of GRT7041 in Healthy Participants","status":"RECRUITING","sponsor":"Grünenthal GmbH","startDate":"2026-01-14","conditions":"Treatment of Pain","enrollment":70},{"nctId":"NCT05306899","phase":"PHASE3","title":"Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches","status":"RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2022-06-01","conditions":"Chronic Daily Headache","enrollment":56},{"nctId":"NCT04871308","phase":"NA","title":"Dexmedetomidine and Myocardial Protection","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2021-07-07","conditions":"Cardiac Surgery, Cardiopulmonary Bypass","enrollment":224},{"nctId":"NCT05505630","phase":"EARLY_PHASE1","title":"The Effects of Sedatives on Tobacco Use Disorder Version 2","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-01-31","conditions":"Tobacco Smoking","enrollment":20},{"nctId":"NCT07347886","phase":"NA","title":"Clinical Outcomes of Sedation in Cataract Surgery Performed Under Topical Anesthesia","status":"NOT_YET_RECRUITING","sponsor":"Istanbul University - Cerrahpasa","startDate":"2026-01","conditions":"Cataract","enrollment":120},{"nctId":"NCT06496750","phase":"PHASE2","title":"Ketamine for Methamphetamine Use Disorder","status":"RECRUITING","sponsor":"University of Texas Southwestern Medical Center","startDate":"2024-09-11","conditions":"Substance Use Disorders, Substance Use, Methamphetamine Abuse","enrollment":120},{"nctId":"NCT05631704","phase":"PHASE1","title":"A Study to Investigate Safety, Tolerability, and Pharmacokinetics (PK) of VH4524184 and the Potential for Changes in Cytochrome P450 3A (CYP3A) Activity","status":"COMPLETED","sponsor":"ViiV Healthcare","startDate":"2022-12-02","conditions":"HIV Infections","enrollment":84},{"nctId":"NCT06692192","phase":"PHASE1","title":"The RECAP2 Study: Midazolam and Psilocybin","status":"RECRUITING","sponsor":"University of Wisconsin, Madison","startDate":"2025-08-07","conditions":"Psilocybin","enrollment":60},{"nctId":"NCT06417125","phase":"PHASE4","title":"Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children","status":"COMPLETED","sponsor":"Fujian Provincial Hospital","startDate":"2024-05-22","conditions":"Behavior Problem","enrollment":324},{"nctId":"NCT06638710","phase":"PHASE2","title":"Efficacy and Safety of Oral Midazolam Used for the Delivery of Care in Elderly Patient With Neurocognitive Disorders and Refusing Care.","status":"RECRUITING","sponsor":"University Hospital, Grenoble","startDate":"2025-07-08","conditions":"Neurocognitive Disorders","enrollment":30},{"nctId":"NCT07166666","phase":"NA","title":"Study Comparing Atomizerd Midazolam & Fentanyl and Dexmedomidine for Procedural Sedation in Adult and Pediatric Patient (2 to 60 Years Old)","status":"NOT_YET_RECRUITING","sponsor":"Oman Medical Speciality Board","startDate":"2025-09-01","conditions":"Sedation, Analgesia Assessment","enrollment":128},{"nctId":"NCT06330584","phase":"PHASE2","title":"Administration of Intranasal Midazolam for Anxiety in Palliative Care","status":"RECRUITING","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2024-12-20","conditions":"Anxiety, Acute Anxiety, Palliative Care","enrollment":36},{"nctId":"NCT07154147","phase":"PHASE4","title":"Oral vs IV Sedation for Cataract Surgery in Older Adults","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2025-08-12","conditions":"Cataract Surgery, Sedation, Cognition Function","enrollment":20},{"nctId":"NCT05163522","phase":"PHASE1","title":"First-Time-in-Human (FTIH) Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of VH4004280 in Healthy Participants","status":"COMPLETED","sponsor":"ViiV Healthcare","startDate":"2021-12-13","conditions":"HIV Infections","enrollment":73},{"nctId":"NCT07064408","phase":"NA","title":"Subanesthetic Esketamine for Hemodynamic Stability and Recovery in Elderly Thoracic Surgery Patients","status":"COMPLETED","sponsor":"Hebei Medical University Fourth Hospital","startDate":"2023-06-01","conditions":"Hemodynamic Instability, Postoperative Recovery, Thoracic Surgery","enrollment":230},{"nctId":"NCT06345755","phase":"PHASE1","title":"A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics of VX-407 in Healthy Participants","status":"COMPLETED","sponsor":"Vertex Pharmaceuticals Incorporated","startDate":"2024-04-17","conditions":"Autosomal Dominant Polycystic Kidney Disease (ADPKD)","enrollment":159},{"nctId":"NCT07021521","phase":"NA","title":"Midazolam Efficacy/Safety in Pre-Eclamptic C-Section Sedation","status":"COMPLETED","sponsor":"Zhuji People's Hospital of Zhejiang Province","startDate":"2021-04-05","conditions":"Midazolam, Pre-eclampsia, Cesarean Section","enrollment":124},{"nctId":"NCT06279234","phase":"PHASE1","title":"A Study to Learn How Different Amounts of PF-06954522 Are Tolerated and Act in Adults With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Pfizer","startDate":"2024-02-20","conditions":"Type 2 Diabetes Mellitus (T2DM), Obesity","enrollment":50},{"nctId":"NCT06957704","phase":"PHASE3","title":"Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents","status":"NOT_YET_RECRUITING","sponsor":"Federal University of São Paulo","startDate":"2025-05","conditions":"Depressive Disorder, Suicidal Ideas","enrollment":60},{"nctId":"NCT03185819","phase":"PHASE2","title":"Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2017-10-05","conditions":"Depressive Disorder, Major","enrollment":147},{"nctId":"NCT06948032","phase":"PHASE1","title":"Study of BLU-808 in Healthy Adult Participants","status":"COMPLETED","sponsor":"Blueprint Medicines Corporation","startDate":"2024-08-07","conditions":"Healthy Participants","enrollment":95},{"nctId":"NCT06533280","phase":"PHASE1","title":"VH3739937 Phase 1 Multiple Ascending Dose (MAD) Study in Healthy Volunteers Including Relative Bioavailability (RBA), Optional Food Effect (FE), and Drug-drug Interaction (DDI)","status":"WITHDRAWN","sponsor":"ViiV Healthcare","startDate":"2024-08-02","conditions":"HIV Infections","enrollment":""},{"nctId":"NCT02461927","phase":"PHASE1, PHASE2","title":"Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2015-01-01","conditions":"Major Depressive Disorder, Alcohol Use Disorder","enrollment":65},{"nctId":"NCT03624595","phase":"NA","title":"Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Dong-Xin Wang","startDate":"2019-04-16","conditions":"Cardiac Surgery, Cardiopulmonary Bypass, Dexmedetomidine","enrollment":502},{"nctId":"NCT03754959","phase":"PHASE1","title":"This Study in Healthy Men Tests How Different Doses of BI 1358894 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 1358894 Affects the Way the Body Breaks Down Midazolam","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2018-12-18","conditions":"Healthy","enrollment":50},{"nctId":"NCT05393271","phase":"PHASE1","title":"First-Time-in-Human (FTIH) Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of VH4011499 in Healthy Participants","status":"COMPLETED","sponsor":"ViiV Healthcare","startDate":"2022-10-03","conditions":"HIV Infections","enrollment":73},{"nctId":"NCT06899724","phase":"NA","title":"Methoxyflurane for Analgesia During Hysteroscopy","status":"NOT_YET_RECRUITING","sponsor":"Dr. John A. Thiel Medical Professional Corporation","startDate":"2025-06-01","conditions":"Analgesia","enrollment":54},{"nctId":"NCT06205381","phase":"PHASE1","title":"Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers","status":"COMPLETED","sponsor":"Aeovian Pharmaceuticals, Inc.","startDate":"2024-01-31","conditions":"Healthy Participants","enrollment":89},{"nctId":"NCT04274361","phase":"NA","title":"Ketamine for Pain Control After Severe Traumatic Injury","status":"COMPLETED","sponsor":"Medical College of Wisconsin","startDate":"2021-01-20","conditions":"Hospital Inpatient Trauma Injury, Pain Management","enrollment":93},{"nctId":"NCT05895838","phase":"PHASE3","title":"The Danish Out-of-Hospital Cardiac Arrest Study","status":"RECRUITING","sponsor":"Christian Hassager","startDate":"2023-06-16","conditions":"Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome","enrollment":1000},{"nctId":"NCT06752759","phase":"PHASE3","title":"Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting","status":"RECRUITING","sponsor":"Theresa Jacob, PhD, MPH","startDate":"2024-10-16","conditions":"Severe Depression, Moderate Depression, Ketamine","enrollment":40},{"nctId":"NCT03084536","phase":"PHASE2","title":"PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2017-06-07","conditions":"Breast Cancer, Breast Cancer Female, Cancer of Breast","enrollment":134},{"nctId":"NCT03279978","phase":"PHASE1","title":"This Study Tests How Healthy Men Tolerate Different Doses of BI 730357 and How the Metabolism of Midazolam is Affected by BI 730357","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2018-01-09","conditions":"Healthy, Psoriasis","enrollment":83},{"nctId":"NCT05736198","phase":"","title":"Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation","status":"RECRUITING","sponsor":"University of Illinois at Chicago","startDate":"2024-08-12","conditions":"Awake Fiberoptic Intubation, Difficult Airway","enrollment":96},{"nctId":"NCT05945147","phase":"PHASE2","title":"Ketamine and Midazolam Infusions for CRPS: Feasibility Study","status":"WITHDRAWN","sponsor":"Stanford University","startDate":"2099-01-01","conditions":"Complex Regional Pain Syndromes","enrollment":""},{"nctId":"NCT05833113","phase":"NA","title":"Effects of Transcutaneous Electrical Nerve Stimulation for Postoperative Quality of Recovery After Shoulder Surgery","status":"COMPLETED","sponsor":"Karaman Training and Research Hospital","startDate":"2023-04-27","conditions":"Quality of Recovery","enrollment":80},{"nctId":"NCT02952924","phase":"PHASE1","title":"A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of RO7049389 in Healthy Volunteers and Chronic Hepatitis B Virus (HBV) Infected Participants","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2016-12-14","conditions":"Hepatitis B, Chronic","enrollment":192},{"nctId":"NCT05779657","phase":"PHASE2, PHASE3","title":"Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus","status":"COMPLETED","sponsor":"Sohag University","startDate":"2023-03-21","conditions":"Generalized Convulsive Status Epilepticus","enrollment":144},{"nctId":"NCT06090422","phase":"PHASE1, PHASE2","title":"Ketamine for Combined Depression and Alcohol Use Disorder","status":"NOT_YET_RECRUITING","sponsor":"University Hospital of North Norway","startDate":"2025-01-01","conditions":"Depression, Alcohol Use Disorder","enrollment":34},{"nctId":"NCT06383273","phase":"PHASE3","title":"A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)","status":"RECRUITING","sponsor":"Melt Pharmaceuticals","startDate":"2024-05-01","conditions":"Cataract","enrollment":528},{"nctId":"NCT04475848","phase":"PHASE1","title":"A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2020-07-15","conditions":"Autistic Disorder, Autism Spectrum Disorder, Child Development Disorders, Pervasive","enrollment":88},{"nctId":"NCT05866055","phase":"PHASE1","title":"A Phase 1 Dose Escalation Study of VX-973 in Healthy Adults","status":"COMPLETED","sponsor":"Vertex Pharmaceuticals Incorporated","startDate":"2023-05-10","conditions":"Pain","enrollment":30},{"nctId":"NCT06063343","phase":"PHASE1","title":"Evaluation of Safety, Tolerability, Pharmacokinetics, Food Effect and Interaction With Midazolam in Healthy Volunteers After Oral Single and Multiple Ascending Dosing of KAND145","status":"COMPLETED","sponsor":"Novakand Pharma AB","startDate":"2023-11-09","conditions":"Ovarian Cancer","enrollment":50},{"nctId":"NCT03782662","phase":"PHASE1","title":"A Study to Learn About the Drug-drug Interactions of Sisunatovir in Healthy Adult Participants","status":"COMPLETED","sponsor":"Pfizer","startDate":"2018-11-07","conditions":"Respiratory Syncytial Virus Infections","enrollment":82},{"nctId":"NCT04537897","phase":"PHASE1","title":"A Study in Healthy Men and Women Who Are Either Between 18 - 45 Years or Between 65 - 80 Years to Test How Different Doses of BI 474121 Are Tolerated","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2020-10-06","conditions":"Healthy","enrollment":70},{"nctId":"NCT00937924","phase":"PHASE4","title":"Adjunct Sedatives in Endoscopic Ultrasound (EUS) and Endoscopic Retrograde Cholangiopancreatography (ERCP) Procedures","status":"COMPLETED","sponsor":"University of California, Irvine","startDate":"2008-02","conditions":"Endoscopic Ultrasound (EUS), Endoscopic Retrograde Cholangiopancreatography (ERCP)","enrollment":304},{"nctId":"NCT06103721","phase":"PHASE4","title":"Role of Nebulized Dexmedetomidine in Blunting the Effects of Direct Laryngoscopy and Endotracheal Tube on Heart Rate and Blood Pressure.","status":"UNKNOWN","sponsor":"Muhammad Haroon Anwar","startDate":"2023-11-21","conditions":"Hemodynamic Instability","enrollment":126},{"nctId":"NCT04912115","phase":"PHASE2","title":"Randomized, Double-Blind, Active Placebo-Controlled Study of Ketamine to Treat Levodopa-Induced Dyskinesia","status":"SUSPENDED","sponsor":"PharmaTher Inc.","startDate":"2021-10-05","conditions":"Dyskinesias, Movement Disorders, Central Nervous System Diseases","enrollment":30},{"nctId":"NCT06087562","phase":"PHASE4","title":"iPACK Block for Total Knee Arthroplasty","status":"UNKNOWN","sponsor":"Poznan University of Medical Sciences","startDate":"2020-06-16","conditions":"Knee Osteoarthritis, Knee Pain Chronic, Knee Disease","enrollment":350},{"nctId":"NCT05160987","phase":"NA","title":"Effect of Remimazolam With Protocolized Sedation on Critical Ill, Mechanical Ventilated Patients Compared With Midazolam","status":"UNKNOWN","sponsor":"Zhujiang Hospital","startDate":"2022-03-29","conditions":"Sedation and Analgesia","enrollment":440},{"nctId":"NCT05944380","phase":"PHASE4","title":"PENG Block for Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2020-06-16","conditions":"Hip Osteoarthritis, Hip Arthropathy, Hip Disease","enrollment":556},{"nctId":"NCT03965728","phase":"PHASE1","title":"Study to Investigate Safety, Tolerability, Pharmacokinetics, and Drug-drug Interaction of Multiple Oral Doses of BAY1830839 in Healthy Male Participants","status":"COMPLETED","sponsor":"Bayer","startDate":"2019-06-05","conditions":"Healthy Volunteers","enrollment":67},{"nctId":"NCT05518734","phase":"PHASE1","title":"A Phase 1 Dose Escalation Study of VX-708 in Healthy Participants","status":"COMPLETED","sponsor":"Vertex Pharmaceuticals Incorporated","startDate":"2022-09-17","conditions":"Pain","enrollment":64},{"nctId":"NCT05770960","phase":"PHASE4","title":"Colonic Motor Patterns in Healthy Volunteers","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2018-06-27","conditions":"Opioid-Induced Constipation","enrollment":15},{"nctId":"NCT04378426","phase":"PHASE2","title":"Nitrous Oxide for PTSD","status":"TERMINATED","sponsor":"VA Office of Research and Development","startDate":"2021-10-07","conditions":"PTSD","enrollment":1},{"nctId":"NCT04571879","phase":"PHASE3","title":"Nebulized Lidocaine and Intranasal Midazolam for NGT Insertion in Children","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2021-08-25","conditions":"Procedural Anxiety, Procedural Pain","enrollment":48},{"nctId":"NCT01845441","phase":"PHASE2","title":"Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions","status":"TERMINATED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2012-04","conditions":"Stroke, Brain Ischemia, Vasospasm, Intracranial","enrollment":7},{"nctId":"NCT05133518","phase":"PHASE2","title":"A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)","status":"COMPLETED","sponsor":"Melt Pharmaceuticals","startDate":"2021-07-20","conditions":"Cataract","enrollment":338},{"nctId":"NCT04586985","phase":"PHASE1","title":"Safety, Tolerability and Pharmacokinetics of FTX-6058","status":"COMPLETED","sponsor":"Fulcrum Therapeutics","startDate":"2020-10-26","conditions":"Healthy Adult Subjects, Sickle Cell Disease","enrollment":109},{"nctId":"NCT04459377","phase":"PHASE4","title":"Ketamine Analgesia in Third Molar Surgery","status":"COMPLETED","sponsor":"Dalarna County Council, Sweden","startDate":"2017-02-14","conditions":"Pain, Postoperative","enrollment":168},{"nctId":"NCT03325712","phase":"PHASE1","title":"This Study in Healthy Men Tests How Different Doses of BI 705564 Are Taken up in the Body and How Well They Are Tolerated. The Study Also Tests How BI 705564 Affects the Way the Body Breaks Down Midazolam","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2017-11-17","conditions":"Healthy","enrollment":60},{"nctId":"NCT04019834","phase":"EARLY_PHASE1","title":"Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy","status":"COMPLETED","sponsor":"University of Alabama at Birmingham","startDate":"2020-07-06","conditions":"Breast Cancer, Mastectomy, Anesthesia, Local","enrollment":21},{"nctId":"NCT04727138","phase":"PHASE1","title":"3-part Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EXS21546","status":"COMPLETED","sponsor":"Exscientia AI Limited","startDate":"2020-12-08","conditions":"Oncology","enrollment":64},{"nctId":"NCT05334537","phase":"NA","title":"Effect of Aromatherapy on Perioperative Anxiety Level in Cesarean Sections","status":"COMPLETED","sponsor":"Kahramanmaras Sutcu Imam University","startDate":"2020-06-01","conditions":"Anxiety, Midazolam Overdose, Breast Feeding","enrollment":96},{"nctId":"NCT04508504","phase":"NA","title":"PENG Block for Arthroscopic Hip Surgery","status":"COMPLETED","sponsor":"University of Virginia","startDate":"2020-12-01","conditions":"Postoperative Pain, Hip Arthroscopy","enrollment":70},{"nctId":"NCT05192629","phase":"PHASE3","title":"Intranasal Dexmedetomidine Versus Oral Midazolam as Premedication for Propofol Sedation in Pediatric Patients Undergoing Magnetic Resonance Imaging","status":"UNKNOWN","sponsor":"Brugmann University Hospital","startDate":"2022-03-09","conditions":"MRI, Pediatric Sedation, Midazolam","enrollment":250},{"nctId":"NCT04493931","phase":"PHASE1","title":"Drug-drug Interaction Study of Gepotidacin","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2020-08-14","conditions":"Infections, Bacterial","enrollment":64},{"nctId":"NCT04147715","phase":"PHASE1","title":"Evaluation of Safety, Tolerability, Pharmacokinetics, Drug-Drug and Food Interactions of Single and Multiple Doses of S-648414 in Healthy Adults","status":"COMPLETED","sponsor":"Shionogi","startDate":"2019-10-09","conditions":"Healthy Volunteer","enrollment":98},{"nctId":"NCT05078372","phase":"PHASE2","title":"Ropivacaine and Midazolam by Intraarticular vs Epidural Administration in Arthroscopic ACL","status":"COMPLETED","sponsor":"Universidad Autonoma de Nuevo Leon","startDate":"2019-01-31","conditions":"Anterior Cruciate Ligament Injuries, Anesthesia Injection Site, Knee Injuries","enrollment":108},{"nctId":"NCT03535168","phase":"PHASE1, PHASE2","title":"Repeat Doses of BAY1902607 in Healthy Males and Proof of Concept in Chronic Cough Patients","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-05-29","conditions":"Cough","enrollment":59},{"nctId":"NCT04027192","phase":"PHASE1","title":"Study to Test the Safety of Increasing Multiple Doses of BAY2328065 Given by Mouth, How the Drug is Tolerated and Acts in the Human Body of Healthy Male Participants. Alteration of the Study Drug Effects by Another Drug and the Availability of the Drug Given in Different Formulations is Also Tested.","status":"COMPLETED","sponsor":"Bayer","startDate":"2019-07-31","conditions":"Endometriosis","enrollment":50},{"nctId":"NCT02290873","phase":"PHASE3","title":"A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients","status":"COMPLETED","sponsor":"Paion UK Ltd.","startDate":"2015-03-30","conditions":"Colonoscopy","enrollment":461},{"nctId":"NCT02532647","phase":"PHASE3","title":"Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy","status":"COMPLETED","sponsor":"Paion UK Ltd.","startDate":"2015-11","conditions":"Colonoscopy","enrollment":79},{"nctId":"NCT03246724","phase":"PHASE4","title":"Oral Versus Intravenous Sedation for Ocular Procedures","status":"COMPLETED","sponsor":"Boston Medical Center","startDate":"2017-10-16","conditions":"Surgery, Sedation","enrollment":327},{"nctId":"NCT02655614","phase":"PHASE1","title":"A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis","status":"COMPLETED","sponsor":"Genentech, Inc.","startDate":"2016-05-31","conditions":"Amyotrophic Lateral Sclerosis","enrollment":54},{"nctId":"NCT03140527","phase":"PHASE1","title":"Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis","status":"COMPLETED","sponsor":"Proteostasis Therapeutics, Inc.","startDate":"2017-04-10","conditions":"Healthy Volunteer, Cystic Fibrosis","enrollment":171},{"nctId":"NCT00142233","phase":"PHASE3","title":"EUROPAC-2 - Pain Treatment of Hereditary and Idiopathic Pancreatitis","status":"COMPLETED","sponsor":"University Medicine Greifswald","startDate":"2005-06-06","conditions":"Pancreatitis","enrollment":295},{"nctId":"NCT02296892","phase":"PHASE3","title":"A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy","status":"COMPLETED","sponsor":"Paion UK Ltd.","startDate":"2015-04","conditions":"Bronchoscopy","enrollment":446},{"nctId":"NCT01967433","phase":"PHASE4","title":"Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids","status":"COMPLETED","sponsor":"University of Oklahoma","startDate":"2013-12","conditions":"Colonoscopy, Adjunct Anesthesia Medication","enrollment":120},{"nctId":"NCT04142762","phase":"PHASE1","title":"A Study to Assess CYP3A4 Modulator, Oral Contraceptive, and pH Modifier Drug Interactions for ABI-H2158 in Healthy Adults","status":"COMPLETED","sponsor":"Assembly Biosciences","startDate":"2019-10-18","conditions":"Chronic Hepatitis B","enrollment":80},{"nctId":"NCT04283110","phase":"NA","title":"Impact of Adding Midzolam to Bupavicaine 0.5% in Regional Spinal Anaesthesia on Maternal Middle Cerebral Artery Velocimetry in Parturients With Severer Preeclampsia","status":"UNKNOWN","sponsor":"Minia University","startDate":"2019-01-12","conditions":"Midazolam in Preeclamptic Patients","enrollment":100},{"nctId":"NCT03436121","phase":"PHASE2, PHASE3","title":"Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department","status":"WITHDRAWN","sponsor":"Maria Pacella","startDate":"2019-12","conditions":"Acute Pain, Depression","enrollment":""},{"nctId":"NCT03165097","phase":"PHASE1","title":"Study to Evaluate Safety and Tolerability of ACT-709478 in Healthy Subjects","status":"COMPLETED","sponsor":"Idorsia Pharmaceuticals Ltd.","startDate":"2017-07-07","conditions":"Healthy Subjects","enrollment":46},{"nctId":"NCT01999777","phase":"PHASE3","title":"Study to Evaluate the Safety and Efficacy of USL261 in Patients With Increased Bouts of Seizure Activity in the EMU","status":"COMPLETED","sponsor":"UCB Biopharma S.P.R.L.","startDate":"2013-11","conditions":"Epilepsy","enrollment":62},{"nctId":"NCT03469700","phase":"NA","title":"General Anesthesia vs Paravertebral Block With General Anesthesia For Laparoscopic Sleeve Gastrectomy","status":"UNKNOWN","sponsor":"Makassed General Hospital","startDate":"2018-03-15","conditions":"Pain, Postoperative","enrollment":40},{"nctId":"NCT02522377","phase":"NA","title":"Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2015-08","conditions":"Treatment Resistant Depression, Major Depressive Disorder, Severe Depression","enrollment":15},{"nctId":"NCT03226080","phase":"PHASE4","title":"GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture","status":"WITHDRAWN","sponsor":"Loyola University","startDate":"2017-07-19","conditions":"Hip Fractures, Anesthesia, Spinal, Anesthesia, General","enrollment":""},{"nctId":"NCT00720330","phase":"NA","title":"Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain","status":"TERMINATED","sponsor":"The Cleveland Clinic","startDate":"2008-07","conditions":"Pain, Nausea","enrollment":12},{"nctId":"NCT01158820","phase":"PHASE4","title":"Alternative Sedation During Bronchoscopy","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2010-06","conditions":"Sedation","enrollment":50},{"nctId":"NCT01333059","phase":"NA","title":"Cycling of Sedative Infusions in Critically Ill Pediatric Patients","status":"TERMINATED","sponsor":"Javier Gelvez, MD","startDate":"2010-09","conditions":"Respiratory Failure","enrollment":25},{"nctId":"NCT03725995","phase":"PHASE2, PHASE3","title":"Using Intranasal Midazolam (INM) and Lidocaine for Uncooperative Children","status":"COMPLETED","sponsor":"Tishreen University","startDate":"2017-06-01","conditions":"Burning Nose","enrollment":63},{"nctId":"NCT03199339","phase":"PHASE1","title":"A Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371","status":"COMPLETED","sponsor":"Global Alliance for TB Drug Development","startDate":"2017-08-29","conditions":"Tuberculosis, Tuberculosis, Pulmonary","enrollment":74},{"nctId":"NCT03666390","phase":"NA","title":"Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide","status":"UNKNOWN","sponsor":"Taipei Veterans General Hospital, Taiwan","startDate":"2018-09-10","conditions":"Major Depressive Disorder","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1135,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["normal saline"],"phase":"marketed","status":"active","brandName":"placebo (for midazolam)","genericName":"placebo (for midazolam)","companyName":"Konkuk University Medical Center","companyId":"konkuk-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A placebo has no active pharmacological mechanism; it produces therapeutic effects through psychological and psychophysiological processes. Used for Control arm in midazolam clinical trials.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}