{"id":"placebo-eye-drops-of-0-5-methylcellulose","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild ocular irritation"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Foreign body sensation"}]},"_chembl":{"chemblId":"CHEMBL2109198","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylcellulose is a cellulose derivative that forms a protective film over the cornea and conjunctiva, increasing tear film viscosity and reducing evaporation. It provides mechanical lubrication and hydration to the ocular surface, helping to relieve symptoms of dry eye and protect the epithelium. As a placebo formulation in this trial, it serves as a control comparator rather than an active therapeutic agent.","oneSentence":"Methylcellulose acts as a lubricating and viscosity-enhancing agent that mimics natural tears to provide ocular surface protection and moisture.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:51:18.621Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease (as placebo control in Phase 3 trial)"}]},"trialDetails":[{"nctId":"NCT06601101","phase":"PHASE3","title":"Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus","status":"RECRUITING","sponsor":"University of Campinas, Brazil","startDate":"2024-08-01","conditions":"Keratoconus, Cornea Disease, Eye Diseases","enrollment":36},{"nctId":"NCT04843839","phase":"PHASE2","title":"CHED - Congenital Hereditary Endothelial Dystrophy: New Paradigm Shift in Therapy Using Topical Eye Drops","status":"UNKNOWN","sponsor":"L.V. Prasad Eye Institute","startDate":"2020-12-15","conditions":"Congenital Hereditary Endothelial Dystrophy of Cornea","enrollment":30},{"nctId":"NCT03009799","phase":"PHASE2","title":"Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240)","status":"WITHDRAWN","sponsor":"NicOx","startDate":"2017-01","conditions":"Adenoviral Conjunctivitis","enrollment":""},{"nctId":"NCT00478036","phase":"NA","title":"Comparing Acular LS and Pred Forte in Reducing Post-selective Laser Trabeculoplasty Anterior Chamber Flare and Cells","status":"TERMINATED","sponsor":"University of Colorado, Denver","startDate":"2007-05","conditions":"Open Angle Glaucoma","enrollment":31},{"nctId":"NCT00485108","phase":"NA","title":"Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty","status":"COMPLETED","sponsor":"Queen's University","startDate":"2007-01","conditions":"Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Placebo"],"phase":"phase_3","status":"active","brandName":"Placebo eye drops of 0.5% Methylcellulose","genericName":"Placebo eye drops of 0.5% Methylcellulose","companyName":"University of Campinas, Brazil","companyId":"university-of-campinas-brazil","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylcellulose acts as a lubricating and viscosity-enhancing agent that mimics natural tears to provide ocular surface protection and moisture. Used for Dry eye disease (as placebo control in Phase 3 trial).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}