{"id":"placebo-corifollitropin-alfa","safety":{"commonSideEffects":[{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Abdominal pain/discomfort"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL2108185","moleculeType":"Protein"},"_fixedAt":"2026-03-30T12:11:23.820892","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Corifollitropin alfa is a recombinant FSH variant with an extended half-life due to fusion with the beta subunit of human chorionic gonadotropin (hCG). It binds to FSH receptors on ovarian granulosa cells to promote follicle growth and estrogen production during controlled ovarian hyperstimulation in fertility treatment. The extended half-life allows for less frequent dosing compared to conventional FSH preparations.","oneSentence":"Corifollitropin alfa is a long-acting follicle-stimulating hormone (FSH) analog that stimulates ovarian follicle development for assisted reproductive technology.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:26:50.230Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Controlled ovarian hyperstimulation in women undergoing assisted reproductive technology (ART) for infertility"}]},"_fixedFields":["modality→Biologic"],"trialDetails":[{"nctId":"NCT00703014","phase":"","title":"Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-07-13","conditions":"Pregnancy, Neonates","enrollment":541},{"nctId":"NCT00702273","phase":"","title":"Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-04-19","conditions":"In Vitro Fertilization","enrollment":344},{"nctId":"NCT00702585","phase":"PHASE2","title":"Study to Investigate the Optimal Dose of Org 36286 to Induce Monofollicular Ovulation in Women With WHO Group II Anovulatory Infertility (P07016)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2001-08-01","conditions":"Infertility","enrollment":55},{"nctId":"NCT00702195","phase":"","title":"Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established During Phase II Clinical Trials of Org 36286 (Study 38817)(P06054)(COMPLETED)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2002-01-01","conditions":"Pregnancy","enrollment":29},{"nctId":"NCT00696800","phase":"PHASE3","title":"A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-06-27","conditions":"In Vitro Fertilization","enrollment":1509},{"nctId":"NCT01146418","phase":"PHASE3","title":"Frozen-thawed Embryo Transfer (FTET) Cycle Follow-up Protocol (P06031)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2010-06-02","conditions":"Infertility","enrollment":307},{"nctId":"NCT00702845","phase":"PHASE3","title":"To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-12-28","conditions":"Infertility","enrollment":397},{"nctId":"NCT00702624","phase":"","title":"Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05690 (Care Program) (P05710)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2007-04","conditions":"Pregnancy, Neonates","enrollment":113},{"nctId":"NCT00702546","phase":"","title":"Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2006-12","conditions":"In Vitro Fertilization","enrollment":102},{"nctId":"NCT01144416","phase":"PHASE3","title":"Efficacy and Safety Study of a Single Injection of SCH 900962 Versus Daily recFSH Injections in Women Undergoing Controlled Ovarian Stimulation (Study P06029)","status":"COMPLETED","sponsor":"Organon and Co","startDate":"2010-06","conditions":"Infertility","enrollment":1424}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Placebo Corifollitropin alfa","genericName":"Placebo Corifollitropin alfa","companyName":"Organon and Co","companyId":"organon-and-co","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Corifollitropin alfa is a long-acting follicle-stimulating hormone (FSH) analog that stimulates ovarian follicle development for assisted reproductive technology. Used for Controlled ovarian hyperstimulation in women undergoing assisted reproductive technology (ART) for infertility.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}