{"id":"placebo-carboplatin-etoposide-or-topotecan","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Myelosuppression"},{"rate":"20-40%","effect":"Nausea and vomiting"},{"rate":"20-40%","effect":"Neutropenia"},{"rate":"10-30%","effect":"Thrombocytopenia"},{"rate":"10-30%","effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Carboplatin is a second-generation platinum-based chemotherapy drug that works by forming platinum-DNA adducts, which interfere with DNA replication and transcription. This leads to cell death, particularly in rapidly dividing cancer cells. The exact mechanism of action is not fully understood, but it is thought to involve the formation of platinum-DNA adducts that trigger apoptosis and inhibit cell cycle progression.","oneSentence":"Carboplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:26:45.995Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced ovarian cancer"},{"name":"Small cell lung cancer"},{"name":"Non-small cell lung cancer"},{"name":"Testicular cancer"},{"name":"Urothelial cancer"}]},"trialDetails":[{"nctId":"NCT04902885","phase":"PHASE3","title":"Phase 3 Study Evaluating Efficacy, Safety and Pharmacokinetics of Trilaciclib In Small Cell Lung Cancer Patients","status":"COMPLETED","sponsor":"Jiangsu Simcere Pharmaceutical Co., Ltd.","startDate":"2021-05-25","conditions":"Extensive-stage Small-cell Lung Cancer","enrollment":95}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3632,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["placebo plus chemotherapy"],"phase":"phase_3","status":"active","brandName":"placebo, carboplatin, etoposide，or Topotecan","genericName":"placebo, carboplatin, etoposide，or Topotecan","companyName":"Jiangsu Simcere Pharmaceutical Co., Ltd.","companyId":"jiangsu-simcere-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carboplatin is a platinum-based chemotherapy drug that works by crosslinking DNA, thereby inhibiting DNA replication and transcription. Used for Advanced ovarian cancer, Small cell lung cancer, Non-small cell lung cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}