{"id":"placebo-capsule-vitamin-k1","safety":{"commonSideEffects":[{"rate":null,"effect":"Adverse events unlikely at nutritional doses"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin K1 (phylloquinone) is an essential cofactor required for the post-translational carboxylation of glutamic acid residues in vitamin K-dependent proteins. This carboxylation is critical for the activation of coagulation factors II, VII, IX, and X, as well as anticoagulant proteins C and S. In this Phase 3 trial context, the placebo capsule containing Vitamin K1 serves as the control arm, providing baseline nutritional vitamin K supplementation.","oneSentence":"Vitamin K1 acts as a cofactor for gamma-glutamyl carboxylase, enabling the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) and other regulatory proteins.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:26:40.194Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Placebo control in Phase 3 clinical trial (specific indication unknown)"}]},"trialDetails":[{"nctId":"NCT05505552","phase":"NA","title":"Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis:","status":"ACTIVE_NOT_RECRUITING","sponsor":"Tufts University","startDate":"2023-09-20","conditions":"Osteo Arthritis Knee","enrollment":37},{"nctId":"NCT05018221","phase":"PHASE3","title":"Better Evidence and Translation for Calciphylaxis","status":"RECRUITING","sponsor":"University of Sydney","startDate":"2021-08-26","conditions":"Calciphylaxis","enrollment":350},{"nctId":"NCT04780061","phase":"PHASE3","title":"Dietary Supplements for COVID-19","status":"TERMINATED","sponsor":"The Canadian College of Naturopathic Medicine","startDate":"2021-07-12","conditions":"Covid19","enrollment":90},{"nctId":"NCT01638182","phase":"NA","title":"Biocomparison Study","status":"COMPLETED","sponsor":"Maastricht University Medical Center","startDate":"2011-03","conditions":"Bone Health, Vascular Health","enrollment":81},{"nctId":"NCT01235325","phase":"PHASE4","title":"The Effect of Vitamin K Supplementation on Bone Health in Adult Crohn's Disease Patients","status":"COMPLETED","sponsor":"University College Cork","startDate":"2008-07","conditions":"Supplementation, Bone Health, Crohn's Disease","enrollment":70},{"nctId":"NCT00698984","phase":"NA","title":"Investigation of the Effect of BONISTEIN(R) Bone Blend on Bone Mineral Density/Content and Biomarkers of Bone Health","status":"COMPLETED","sponsor":"dsm-firmenich Switzerland AG","startDate":"2007-01","conditions":"Osteoporosis","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Matching placebo capsule"],"phase":"phase_3","status":"active","brandName":"Placebo capsule (Vitamin K1)","genericName":"Placebo capsule (Vitamin K1)","companyName":"University of Sydney","companyId":"university-of-sydney","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitamin K1 acts as a cofactor for gamma-glutamyl carboxylase, enabling the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) and other regulatory proteins. Used for Placebo control in Phase 3 clinical trial (specific indication unknown).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}