{"id":"placebo-botulinum-toxin-a","safety":{"commonSideEffects":[{"rate":"5-15","effect":"Headache"},{"rate":"5-10","effect":"Neck pain"},{"rate":"5-10","effect":"Injection site pain"},{"rate":"5-20","effect":"Muscle weakness"},{"rate":"1-5","effect":"Eyelid ptosis"},{"rate":"1-5","effect":"Dry mouth"},{"rate":"1-5","effect":"Dysphagia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Botulinum toxin A is a neurotoxin that irreversibly cleaves SNARE proteins (specifically SNAP-25) required for acetylcholine vesicle fusion and release at the presynaptic terminal. This prevents neuromuscular transmission and results in flaccid paralysis of the targeted muscle. The effect is temporary, lasting 3-4 months, after which nerve terminals regenerate and muscle function returns.","oneSentence":"Botulinum toxin A blocks acetylcholine release at the neuromuscular junction by cleaving SNARE proteins, causing temporary muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:36:05.814Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cervical dystonia"},{"name":"Blepharospasm"},{"name":"Hemifacial spasm"},{"name":"Wrinkles and facial lines (cosmetic)"},{"name":"Hyperhidrosis"},{"name":"Chronic migraine"}]},"trialDetails":[{"nctId":"NCT07018700","phase":"PHASE3","title":"A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine","status":"RECRUITING","sponsor":"Merz Therapeutics GmbH","startDate":"2025-08-21","conditions":"Episodic Migraine","enrollment":990},{"nctId":"NCT07018713","phase":"PHASE3","title":"A Clinical Trial to Evaluate Efficacy and Safety 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