{"id":"pl-nasal-spray","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nasal irritation"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"PL nasal spray works by decreasing the production of inflammatory chemicals in the nasal mucosa, thereby reducing swelling and congestion. This is achieved through the action of the corticosteroid on the glucocorticoid receptor, which regulates the expression of genes involved in inflammation. By reducing inflammation, PL nasal spray helps to alleviate symptoms of nasal congestion, runny nose, and sinus pressure associated with allergic rhinitis and other conditions.","oneSentence":"PL nasal spray is a corticosteroid used to reduce inflammation in the nasal passages.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:00:31.791Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis"},{"name":"Nasal congestion"},{"name":"Sinus pressure"}]},"trialDetails":[{"nctId":"NCT01944046","phase":"PHASE2","title":"Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors","status":"COMPLETED","sponsor":"Linmarie Sikich","startDate":"2014-08-01","conditions":"Autism Spectrum Disorders","enrollment":290},{"nctId":"NCT03640156","phase":"PHASE3","title":"Modulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin","status":"COMPLETED","sponsor":"KU Leuven","startDate":"2018-07-26","conditions":"Autism Spectrum Disorder","enrollment":25},{"nctId":"NCT03010670","phase":"PHASE4","title":"Oxytocin and Interpersonal Motor Resonance","status":"COMPLETED","sponsor":"KU Leuven","startDate":"2016-01","conditions":"Social Behavior","enrollment":27},{"nctId":"NCT01007253","phase":"PHASE4","title":"Effect of Veramyst and Olopatadine 0.2% Opthalmic Solution on Allergy Symptoms","status":"COMPLETED","sponsor":"University of Chicago","startDate":"2009-11","conditions":"Seasonal Allergic Rhinitis","enrollment":21}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"PL nasal spray","genericName":"PL nasal spray","companyName":"University of Chicago","companyId":"university-of-chicago","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PL nasal spray is a corticosteroid used to reduce inflammation in the nasal passages. Used for Allergic rhinitis, Nasal congestion, Sinus pressure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}