{"id":"pitocin","rwe":[],"tags":[],"safety":{"boxedWarnings":["IMPORTANT NOTICE Elective induction of labor is defined as the initiation of labor in a pregnant individual who has no medical indications for induction. Since the available data are inadequate to evaluate the benefits-to-risks considerations, Pitocin is not indicated for elective induction of labor."],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[{"effect":"Nausea","drugRate":"","severity":"common","organSystem":""},{"effect":"Vomiting","drugRate":"","severity":"common","organSystem":""},{"effect":"Premature ventricular contractions","drugRate":"","severity":"common","organSystem":""},{"effect":"Cardiac arrhythmia","drugRate":"","severity":"common","organSystem":""},{"effect":"Hypertensive episodes","drugRate":"","severity":"common","organSystem":""},{"effect":"Bradycardia","drugRate":"","severity":"common","organSystem":""}],"contraindications":[],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[{"effect":"Uterine rupture","drugRate":"","severity":"serious"},{"effect":"Severe water intoxication with convulsions and coma","drugRate":"","severity":"serious"},{"effect":"Maternal death due to oxytocin-induced water intoxication","drugRate":"","severity":"serious"},{"effect":"Permanent CNS or brain damage","drugRate":"","severity":"serious"},{"effect":"Postpartum hemorrhage","drugRate":"","severity":"serious"},{"effect":"Subarachnoid hemorrhage","drugRate":"","severity":"serious"},{"effect":"Fatal afibrinogenemia","drugRate":"","severity":"serious"},{"effect":"Fetal death","drugRate":"","severity":"serious"},{"effect":"Neonatal seizures","drugRate":"","severity":"serious"},{"effect":"Anaphylactic reaction","drugRate":"","severity":"serious"}]},"trials":[],"_chembl":null,"aliases":["oxytocin","Oxytocin infusion alone","IV Oxytocin"],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T11:56:36.139914","_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=pitocin","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:16:03.937868+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:16:11.560194+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pitocin","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:16:12.291551+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Oxytocin receptor agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:16:13.122433+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL395429/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:16:13.011718+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"6d4b2c25-2e5d-49b5-93bc-2ae8a20916d1","title":"PITOCIN (OXYTOCIN) INJECTION [PAR HEALTH USA, LLC]"},"ecosystem":[],"mechanism":{"modality":"Peptide"},"_scrapedAt":"2026-03-27T23:36:02.671Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:16:14.896824+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"dataSources":[],"indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["modality→Peptide"],"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT01113229","phase":"PHASE4","title":"Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-03","conditions":"Hemorrhage; Complicating Delivery","enrollment":1721},{"nctId":"NCT07492186","phase":"NA","title":"3-hour Versus 12-hour Double-balloon Catheter for Labor Induction: a Randomized Trial","status":"NOT_YET_RECRUITING","sponsor":"Centre Hospitalier de PAU","startDate":"2027-03-01","conditions":"Patients With an Indication for Induction-to-birth","enrollment":280},{"nctId":"NCT05079841","phase":"PHASE4","title":"The Stimulation To Induce Mothers Study","status":"RECRUITING","sponsor":"Yale University","startDate":"2021-11-15","conditions":"Oxytocin, Labor Pain, Induction of Labor Affected Fetus / Newborn","enrollment":988},{"nctId":"NCT07461571","phase":"NA","title":"Improving Safe Vaginal Deliveries for Delivering Mothers by Implementing an Intervention Package of 11 Evidence-based Practices and Robson Classification at a Semi-urban Hospital in Dhaka, Bangladesh","status":"COMPLETED","sponsor":"Ashulia Women and Children Hospital","startDate":"2017-06-01","conditions":"Caesarean Section","enrollment":2475},{"nctId":"NCT04228289","phase":"PHASE2","title":"Oxytocin to Treat PTSD","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2021-01-01","conditions":"PTSD","enrollment":180},{"nctId":"NCT07461428","phase":"NA","title":"EVALUATİON OF THE EFFECTİVENESS OF A MODEL-BASED HYPNOBREASTFEEDİNG EDUCATİON PROGRAM GİVEN TO PRİMİPAROUS PREGNANT WOMEN","status":"ENROLLING_BY_INVITATION","sponsor":"Ankara Yildirim Beyazıt University","startDate":"2025-05-20","conditions":"Healthy Subjects, Healthy (Controls), Pregnancy","enrollment":80},{"nctId":"NCT05754073","phase":"PHASE2","title":"Oxytocin Effects on Bone in Children With Autism Spectrum Disorder","status":"RECRUITING","sponsor":"Elizabeth Austen Lawson","startDate":"2023-08-01","conditions":"Autism Spectrum Disorder, Bone Health","enrollment":96},{"nctId":"NCT07436286","phase":"NA","title":"Intra-Umbilical Vein Oxytocin Injection as an Adjunct to Active Management of the Third Stage of Labour","status":"COMPLETED","sponsor":"Dangana Zakari Adeka","startDate":"2018-02-01","conditions":"Postpartum Hemorrhage (PPH), Postpartum Hemorrhage Third Stage of Labour Retained Placenta","enrollment":416},{"nctId":"NCT05951452","phase":"","title":"The Developmental Origins of Endometriosis","status":"RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2024-01-08","conditions":"Endometriosis","enrollment":40},{"nctId":"NCT07420127","phase":"PHASE4","title":"Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect","status":"RECRUITING","sponsor":"Rawalpindi Medical College","startDate":"2026-02-13","conditions":"Phenylephrine, Cesarean Birth","enrollment":112},{"nctId":"NCT07430228","phase":"PHASE2","title":"Efficacy of Intravenous Oxytocin to Speed Recovery After THA","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Total Hip Arthroplasty","enrollment":80},{"nctId":"NCT03878589","phase":"PHASE2, PHASE3","title":"Understanding Cognition, Oxytocin & Pain in Elders","status":"COMPLETED","sponsor":"University of Florida","startDate":"2019-08-06","conditions":"Knee Osteoarthritis, Osteoarthritis","enrollment":83},{"nctId":"NCT07425938","phase":"NA","title":"Oxytocin's Effects on Emotional Processing and Its Acting Routes","status":"RECRUITING","sponsor":"University of Electronic Science and Technology of China","startDate":"2026-01-24","conditions":"Healthy Adult Male","enrollment":120},{"nctId":"NCT06987786","phase":"NA","title":"Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-06-01","conditions":"Spine, Low Back Pain, Neck Pain","enrollment":25},{"nctId":"NCT07366359","phase":"NA","title":"PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)","status":"RECRUITING","sponsor":"National Hospital of Obstetrics and Gynecology","startDate":"2026-02-10","conditions":"Premature Rupture of Fetal Membranes, Labor, Induced, Cervical Ripening","enrollment":450},{"nctId":"NCT04903002","phase":"PHASE2, PHASE3","title":"Evaluating the Efficacy of Intranasal Oxytocin on Chronic Pain","status":"ACTIVE_NOT_RECRUITING","sponsor":"Memorial University of Newfoundland","startDate":"2022-04-01","conditions":"Chronic Pain","enrollment":336},{"nctId":"NCT07380529","phase":"NA","title":"Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2024-10-01","conditions":"Postpartum Hemorrhage \\(PPH\\)","enrollment":300},{"nctId":"NCT07276152","phase":"NA","title":"Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2026-01-09","conditions":"Sonic Augmentation Technology","enrollment":22},{"nctId":"NCT07409753","phase":"PHASE2","title":"Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2025-10-22","conditions":"Acute Pain","enrollment":60},{"nctId":"NCT07401160","phase":"NA","title":"Umbilical Cord Drainage to Prevent Postpartum Hemorrhage","status":"RECRUITING","sponsor":"Universidad Nacional Autonoma de Honduras","startDate":"2026-02-15","conditions":"Postpartum Hemorrhage","enrollment":400},{"nctId":"NCT06827951","phase":"","title":"Potential Benefits of Parent Child Interaction Therapy (PCIT)","status":"RECRUITING","sponsor":"University of Florida","startDate":"2025-02-14","conditions":"Autonomic Dysregulation, Anxiety, Depression","enrollment":80},{"nctId":"NCT07214948","phase":"NA","title":"Open, Randomized Feasibility Trial on the Safety and Performance of the INGA Catheter for Labor Induction","status":"NOT_YET_RECRUITING","sponsor":"Aalto University","startDate":"2026-03-15","conditions":"Induction of Birth, Cervical Ripening, Cervical Ripening and Induction of Labor","enrollment":90},{"nctId":"NCT03899961","phase":"PHASE4","title":"Carbetocin Myocardium Trial 2014 Part 2","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2019-04-02","conditions":"Pregnancy Complications","enrollment":240},{"nctId":"NCT07401524","phase":"PHASE4","title":"Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Sheba Medical Center","startDate":"2026-03-01","conditions":"Postpartum Hemorrhage, Twin Pregnancy","enrollment":120},{"nctId":"NCT07390864","phase":"NA","title":"Ergometrine Versus Carbetocin to Decrease Blood Loss in Myomectomy","status":"RECRUITING","sponsor":"Cairo University","startDate":"2026-01-18","conditions":"Myoma;Uterus","enrollment":40},{"nctId":"NCT03991091","phase":"PHASE4","title":"Reducing Neonatal Morbidity by Discontinuing Oxytocin During the Active Phase of 1st Stage of Labor","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2020-01-17","conditions":"Neonatal Morbidity","enrollment":2459},{"nctId":"NCT06039878","phase":"NA","title":"Mother-Baby Study - Observational","status":"RECRUITING","sponsor":"University of Michigan","startDate":"2023-12-21","conditions":"Obesity, Childhood, Obesity","enrollment":300},{"nctId":"NCT07320040","phase":"","title":"Evaluation of Emotion-related Salivary Molecular Biomarkers","status":"RECRUITING","sponsor":"Sys2Diag","startDate":"2022-11-14","conditions":"Emotion","enrollment":240},{"nctId":"NCT06638450","phase":"NA","title":"Clinical Trial for Acupuncture in Adolescents With Psychological Distress and Insomnia","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2026-03","conditions":"Psychological Distress, Insomnia","enrollment":148},{"nctId":"NCT07367672","phase":"NA","title":"The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain","status":"RECRUITING","sponsor":"University of Electronic Science and Technology of China","startDate":"2025-12-01","conditions":"Healthy Participants","enrollment":120},{"nctId":"NCT02910115","phase":"NA","title":"Cooling the Uterus in C-section After Dysfunctional Labor","status":"TERMINATED","sponsor":"Baylor Research Institute","startDate":"2015-05-14","conditions":"Blood Loss, Dysfunctional Labor, Uterine Atony","enrollment":8},{"nctId":"NCT07361263","phase":"NA","title":"Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2026-01-09","conditions":"AVP Deficiency, Diabetes Insipidus","enrollment":28},{"nctId":"NCT07053774","phase":"PHASE2","title":"Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2025-11-05","conditions":"Pain, Acute","enrollment":24},{"nctId":"NCT04897802","phase":"PHASE4","title":"Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)","status":"COMPLETED","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2021-09-13","conditions":"Hypopituitarism, Central Diabetes Insipidus, Panhypopituitarism","enrollment":42},{"nctId":"NCT07353281","phase":"NA","title":"Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention","status":"NOT_YET_RECRUITING","sponsor":"Western Galilee Hospital-Nahariya","startDate":"2026-01-31","conditions":"Postpartum Complication, Postpartum Hemorrhage","enrollment":146},{"nctId":"NCT03900754","phase":"PHASE2","title":"A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in Schizophrenia","status":"TERMINATED","sponsor":"VA Office of Research and Development","startDate":"2020-01-13","conditions":"Schizophrenia","enrollment":26},{"nctId":"NCT07351799","phase":"NA","title":"Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2025-09-22","conditions":"Lactation, Mindfulness, NICU","enrollment":40},{"nctId":"NCT07345858","phase":"","title":"Salivary Oxytocin as a Biomarker of Psychedelic Treatment","status":"ENROLLING_BY_INVITATION","sponsor":"University of Geneva, Switzerland","startDate":"2026-01-05","conditions":"Major Depressive Disorder (MDD)","enrollment":80},{"nctId":"NCT04218409","phase":"EARLY_PHASE1","title":"Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination","status":"RECRUITING","sponsor":"University of Florida","startDate":"2021-09-02","conditions":"Pain","enrollment":45},{"nctId":"NCT06651476","phase":"PHASE2","title":"A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2024-12-05","conditions":"Sunburn","enrollment":38},{"nctId":"NCT07321379","phase":"NA","title":"Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour","status":"NOT_YET_RECRUITING","sponsor":"Copenhagen University Hospital, Hvidovre","startDate":"2026-02-01","conditions":"Prolonged Labor, Labor Dystocia","enrollment":1520},{"nctId":"NCT05782816","phase":"PHASE4","title":"Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor","status":"COMPLETED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2023-04-17","conditions":"Labor Long","enrollment":170},{"nctId":"NCT04523922","phase":"PHASE2","title":"Oxytocin to Enhance Integrated Treatment for AUD and PTSD","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2021-03-29","conditions":"PTSD, Alcohol Use Disorder","enrollment":180},{"nctId":"NCT07318467","phase":"NA","title":"Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2026-01-01","conditions":"Post Partum Hemorrhage","enrollment":80},{"nctId":"NCT07237880","phase":"NA","title":"Use of Papaverine to Shorten the Second Stage/Duration of Labor in Pregnant Women After Cervical Ripening by Double-balloon Catheter","status":"RECRUITING","sponsor":"Hillel Yaffe Medical Center","startDate":"2025-04-22","conditions":"Labor, Induced","enrollment":184},{"nctId":"NCT04303702","phase":"NA","title":"The Role of Oxytocin in the Second Stage of Labor","status":"RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2022-07-01","conditions":"Labor Complication","enrollment":400},{"nctId":"NCT06036004","phase":"PHASE2","title":"Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2024-01-08","conditions":"Central Diabetes Insipidus (cDI)","enrollment":112},{"nctId":"NCT06483659","phase":"PHASE2","title":"Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy","status":"RECRUITING","sponsor":"Brigham and Women's Hospital","startDate":"2025-06-01","conditions":"Postoperative Pain","enrollment":152},{"nctId":"NCT04760496","phase":"PHASE4","title":"Effect of Increased Oxytocin Doses on the Mode of Delivery in Obese Primiparous Women With Spontaneous or Induced Labour","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2021-10-02","conditions":"Obese, Primiparous Women, Oxytocin","enrollment":443},{"nctId":"NCT07299708","phase":"","title":"Effects of Sleep Quality, Anxiety, and Digital Behavior on Labor Progression in Term Primiparous Women: A Prospective Observational Study","status":"COMPLETED","sponsor":"Tepecik Training and Research Hospital","startDate":"2025-08-10","conditions":"Labor Progression, Pregnancy","enrollment":127},{"nctId":"NCT04427709","phase":"PHASE2","title":"Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2020-11-30","conditions":"Chronic Pain, Osteoarthritis, Knee","enrollment":38},{"nctId":"NCT07274501","phase":"NA","title":"The Effect of Music That the Individuals With Moderate Dental Anxiety Have Started Listening to While Waiting","status":"ACTIVE_NOT_RECRUITING","sponsor":"Karadeniz Technical University","startDate":"2025-04-17","conditions":"Dental Anxiety","enrollment":90},{"nctId":"NCT06713473","phase":"NA","title":"Reducing Self-Dehumanization to Examine Oxytocin and Suicide Risk","status":"NOT_YET_RECRUITING","sponsor":"Florida State University","startDate":"2026-08","conditions":"Rehumanization Intervention, Control Intervention","enrollment":50},{"nctId":"NCT02804373","phase":"PHASE2, PHASE3","title":"Effects of Intranasal Administration of Oxytocin in Adults With Prader-Willi Syndrome","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2014-06","conditions":"Prader-Willi Syndrome","enrollment":50},{"nctId":"NCT07265180","phase":"NA","title":"Oxytocin-Augmented Group Psychotherapy for Patients With Schizophrenia - an Oxytocin-dose Comparison","status":"RECRUITING","sponsor":"Charite University, Berlin, Germany","startDate":"2025-09-08","conditions":"Schizophrenia Spectrum Disorders (SSD)","enrollment":120},{"nctId":"NCT04949633","phase":"PHASE3","title":"Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening","status":"RECRUITING","sponsor":"University Hospital, Tours","startDate":"2021-09-28","conditions":"Cervical Ripening, Unfavorable Cervix","enrollment":1494},{"nctId":"NCT06136390","phase":"NA","title":"OXYMIND: Oxytocin-augmented Group Psychotherapy for Patients With Schizophrenia","status":"COMPLETED","sponsor":"Charite University, Berlin, Germany","startDate":"2023-09-30","conditions":"Schizophrenia Spectrum Disorders","enrollment":42},{"nctId":"NCT06803992","phase":"PHASE4","title":"Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter","status":"RECRUITING","sponsor":"HaEmek Medical Center, Israel","startDate":"2025-04-06","conditions":"Induction of Labor","enrollment":140},{"nctId":"NCT06352775","phase":"NA","title":"Calcium Carbonate on Labor Induction","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2024-06-01","conditions":"Pregnancy, Uterine Contraction","enrollment":250},{"nctId":"NCT02477085","phase":"","title":"Methods of Labor Induction and Perinatal Outcomes","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2015-11","conditions":"Induction of Labor","enrollment":3049},{"nctId":"NCT07143266","phase":"","title":"Sleep Disorders in Hypothalamic and Pituitary Damage","status":"RECRUITING","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2025-09-01","conditions":"Hypopituitarism, Sleep Wake Disorders, Hypothalamic Diseases","enrollment":60},{"nctId":"NCT06641141","phase":"NA","title":"The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)","status":"RECRUITING","sponsor":"Ottawa Hospital Research Institute","startDate":"2025-04-07","conditions":"Gestational Diabetes Mellitus (GDM)","enrollment":260},{"nctId":"NCT05664516","phase":"PHASE2","title":"A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2023-03-07","conditions":"Binge-eating Disorder","enrollment":60},{"nctId":"NCT06364228","phase":"PHASE2","title":"Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia","status":"RECRUITING","sponsor":"University of Nebraska","startDate":"2026-01-05","conditions":"Stress","enrollment":32},{"nctId":"NCT05766852","phase":"NA","title":"Potential Benefits of the Somatic Psychoeducational Intervention","status":"COMPLETED","sponsor":"University of Florida","startDate":"2023-10-23","conditions":"Work Related Stress","enrollment":31},{"nctId":"NCT05929339","phase":"PHASE2","title":"Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2023-08-17","conditions":"Acute Pain, Chronic Pain, Healthy Volunteer","enrollment":25},{"nctId":"NCT06580782","phase":"PHASE4","title":"Calcium Carbonate to Augment Labor Contractions","status":"RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2024-11-18","conditions":"Labor Dystocia, Labor Induction, Labor Augmentation","enrollment":60},{"nctId":"NCT03584854","phase":"PHASE4","title":"Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2019-03-01","conditions":"Postpartum Hemorrhage, Uterine Atony","enrollment":100},{"nctId":"NCT06710964","phase":"NA","title":"Inducing Self-Dehumanization to Examine Oxytocin and Suicide Risk","status":"NOT_YET_RECRUITING","sponsor":"Florida State University","startDate":"2026-04","conditions":"Mechanistic Self-Dehumanization Condition, Control Condition","enrollment":50},{"nctId":"NCT07162584","phase":"NA","title":"Oxytocin and Human Defensive Responses in a Dynamic Situation","status":"RECRUITING","sponsor":"University of Electronic Science and Technology of China","startDate":"2025-09-13","conditions":"Healthy","enrollment":80},{"nctId":"NCT05488457","phase":"PHASE2","title":"Oxytocin Pharmacokinetics and Pharmacodynamics","status":"RECRUITING","sponsor":"University of Chicago","startDate":"2025-01-01","conditions":"Post Partum Hemorrhage, Cesarean Section Complications, Blood Loss","enrollment":100},{"nctId":"NCT06605300","phase":"NA","title":"The Effects of Oxytocin and Vasopressin on Delta-beta Cross-frequency Coupling","status":"COMPLETED","sponsor":"University of Electronic Science and Technology of China","startDate":"2024-10-02","conditions":"Healthy","enrollment":120},{"nctId":"NCT06808516","phase":"PHASE2","title":"Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Controls","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2025-07-01","conditions":"Arginine Vasopressin Deficiency, Central Diabetes Insipidus, Oxytocin Deficiency","enrollment":42},{"nctId":"NCT02225600","phase":"NA","title":"The Effect of Oxytocin Administration on Interpersonal Cooperation in Borderline Personality Disorder Patients and Healthy Adults","status":"SUSPENDED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2014-08-26","conditions":"Borderline Personality Disorder","enrollment":40},{"nctId":"NCT06930391","phase":"NA","title":"Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium","status":"RECRUITING","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2025-09-15","conditions":"Postpartum Hemorrhage (Primary)","enrollment":40},{"nctId":"NCT07188207","phase":"NA","title":"Rectal Misoprostol for Reducing Blood Loss in Elective Cesarean Section","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2025-10-01","conditions":"Postpartum Hemorrhage","enrollment":282},{"nctId":"NCT07077655","phase":"NA","title":"Marmet and Oxytocin Massage for Breast Milk Increase","status":"RECRUITING","sponsor":"Ege University","startDate":"2025-08-25","conditions":"Healhty","enrollment":123},{"nctId":"NCT04789148","phase":"PHASE1","title":"Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency","status":"RECRUITING","sponsor":"Elizabeth Austen Lawson","startDate":"2025-09-10","conditions":"Vasopressin Deficiency","enrollment":40},{"nctId":"NCT04373902","phase":"NA","title":"Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia","status":"ACTIVE_NOT_RECRUITING","sponsor":"Erasmus Medical Center","startDate":"2020-05-11","conditions":"Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital, Pulmonary Hypertension","enrollment":140},{"nctId":"NCT04431206","phase":"PHASE2","title":"Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects","status":"TERMINATED","sponsor":"Wake Forest University Health Sciences","startDate":"2020-11-04","conditions":"Osteoarthritis, Knee, Healthy","enrollment":7},{"nctId":"NCT06881459","phase":"NA","title":"The Effect of Oxytocin on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes","status":"COMPLETED","sponsor":"University Hospital, Gentofte, Copenhagen","startDate":"2025-03-25","conditions":"Type 1 Diabetes","enrollment":16},{"nctId":"NCT07140237","phase":"EARLY_PHASE1","title":"The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )","status":"RECRUITING","sponsor":"University of Electronic Science and Technology of China","startDate":"2025-09","conditions":"Healthy Adult Male","enrollment":250},{"nctId":"NCT06725004","phase":"PHASE3","title":"Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction","status":"COMPLETED","sponsor":"Shakeela Ishrat","startDate":"2023-01-01","conditions":"Ovulation Induction, Polycystic Ovary Syndrome","enrollment":60},{"nctId":"NCT05405257","phase":"PHASE1, PHASE2","title":"Oxytocin for Hypermobile Ehlers-Danlos Syndrome","status":"TERMINATED","sponsor":"Baylor College of Medicine","startDate":"2022-05-13","conditions":"Hypermobile Ehlers-Danlos Syndrome, Pain Assessment","enrollment":2},{"nctId":"NCT04478942","phase":"EARLY_PHASE1","title":"PROMMO Trial: Oral Misoprostol vs IV Oxytocin","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2020-10-26","conditions":"Premature Rupture of Membrane, Induction of Labor Affected Fetus / Newborn","enrollment":138},{"nctId":"NCT04818112","phase":"NA","title":"A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2021-07-12","conditions":"Parent-Child Relations, Maternal Behavior, Infant Behavior","enrollment":262},{"nctId":"NCT07119398","phase":"PHASE4","title":"Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM","status":"RECRUITING","sponsor":"Eastern Virginia Medical School","startDate":"2025-07-14","conditions":"Preterm PROM (Pregnancy)","enrollment":80},{"nctId":"NCT04429880","phase":"PHASE2","title":"A Study of Oxytocin PK After IV Administration in Healthy Subjects and Advanced Knee Arthritis Subjects","status":"WITHDRAWN","sponsor":"Wake Forest University Health Sciences","startDate":"2023-01","conditions":"Osteoarthritis, Knee","enrollment":""},{"nctId":"NCT03593473","phase":"PHASE2","title":"Inhaled Oxytocin and HPA Axis Reactivity","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2019-02-07","conditions":"Depression, Postpartum, Anxiety Disorders, Stress, Psychological","enrollment":109},{"nctId":"NCT03878316","phase":"PHASE2","title":"Intranasal Oxytocin for the Treatment of Alcohol Use Disorder","status":"COMPLETED","sponsor":"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","startDate":"2022-06-29","conditions":"Alcohol Use Disorder, Alcohol Misuse","enrollment":100},{"nctId":"NCT07093060","phase":"EARLY_PHASE1","title":"The Effect of Oral Oxytocin and Atosiban on Social Attention","status":"RECRUITING","sponsor":"University of Electronic Science and Technology of China","startDate":"2025-06-09","conditions":"Healhty","enrollment":250},{"nctId":"NCT04117243","phase":"PHASE2","title":"Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-01-20","conditions":"Post Partum Hemorrhage","enrollment":345},{"nctId":"NCT04551482","phase":"PHASE2","title":"Oxytocin for Weight Loss in Adolescents","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2021-07-28","conditions":"Obesity, Adolescent, Oxytocin","enrollment":75},{"nctId":"NCT07006896","phase":"NA","title":"Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin","status":"RECRUITING","sponsor":"University of Pennsylvania","startDate":"2025-07-10","conditions":"Labor Induction, Cesarean Delivery","enrollment":100},{"nctId":"NCT01788072","phase":"PHASE2","title":"INtranasal OXyTocin for the Treatment of Autism Spectrum Disorders","status":"COMPLETED","sponsor":"Holland Bloorview Kids Rehabilitation Hospital","startDate":"2014-06","conditions":"Autism Spectrum Disorder","enrollment":70},{"nctId":"NCT01908205","phase":"PHASE2","title":"Intranasal Oxytocin for the Treatment of Children and Adolescents With Autism Spectrum Disorders (ASD)","status":"COMPLETED","sponsor":"Holland Bloorview Kids Rehabilitation Hospital","startDate":"2013-09","conditions":"Autism Spectrum Disorder","enrollment":60},{"nctId":"NCT06285396","phase":"NA","title":"Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study","status":"SUSPENDED","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2024-03-18","conditions":"Postpartum Hemorrhage","enrollment":96},{"nctId":"NCT07053930","phase":"NA","title":"Comparison of the Mean Duration of 3rd Stage of Labour Between Intraumbilical and Intravenous Oxytocin","status":"COMPLETED","sponsor":"RESnTEC, Institute of Research","startDate":"2024-10-01","conditions":"Labor","enrollment":100},{"nctId":"NCT07031804","phase":"NA","title":"Expectation Effects on Emotional Processing","status":"NOT_YET_RECRUITING","sponsor":"Universitätsklinikum Hamburg-Eppendorf","startDate":"2025-06","conditions":"Expectation Effects on Emotional Processing","enrollment":51},{"nctId":"NCT06970483","phase":"","title":"Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2023-12-01","conditions":"Postpartum Hemorrhage, Cesarean Section Complications, Delivery Complication","enrollment":150}],"_emaApprovals":[],"_faersSignals":[{"count":58,"reaction":"POSTPARTUM HAEMORRHAGE"},{"count":54,"reaction":"EXPOSURE DURING PREGNANCY"},{"count":52,"reaction":"DRUG INEFFECTIVE"},{"count":47,"reaction":"DRUG EXPOSURE DURING PREGNANCY"},{"count":44,"reaction":"FOETAL EXPOSURE DURING PREGNANCY"},{"count":44,"reaction":"MATERNAL EXPOSURE DURING PREGNANCY"},{"count":39,"reaction":"HYPOTENSION"},{"count":35,"reaction":"CAESAREAN SECTION"},{"count":29,"reaction":"PAIN"},{"count":27,"reaction":"OFF LABEL USE"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"chemblId":"CHEMBL395429"},"formularyStatus":[],"_approvalHistory":[{"date":"20000323","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20010924","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19940527","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19991110","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20010308","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19940809","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19970710","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19880216","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19860919","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20210511","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20010308","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20160815","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20001025","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20141002","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20030324","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19960222","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20000301","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20020110","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19940823","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19990222","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19900703","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19801119","type":"ORIG","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19970729","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19870129","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"19840127","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20070727","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20010308","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"},{"date":"20140618","type":"SUPPL","sponsor":"PH HEALTH","applicationNumber":"NDA018261"}],"developmentCodes":[],"ownershipHistory":[],"publicationCount":247,"therapeuticAreas":["Other"],"biosimilarFilings":[],"companionDiagnostics":[],"genericManufacturerList":[],"phase":"marketed","status":"active","brandName":"pitocin","genericName":"pitocin","companyName":"Duke University","companyId":"duke-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":5,"withResults":2},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:16:14.896824+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":false,"safety":true,"trials":true,"score":2}}