{"id":"pirenoxine","rwe":[{"pmid":"41557063","year":"2026","title":"Hydrogen-rich saline treatment modulates proteomic profiles to mitigate cataract development in a N-methyl-N-nitrosourea-induced rat model.","finding":"","journal":"International ophthalmology","studyType":"Clinical Study"},{"pmid":"36012695","year":"2022","title":"The Possible Positive Mechanisms of Pirenoxine in Cataract Formation.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"34708633","year":"2021","title":"Anti-cataract effects of Dajizhi (Euphorbium) eye drops on selenite-induced cataracts in rat.","finding":"","journal":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan","studyType":"Clinical Study"},{"pmid":"32296100","year":"2020","title":"Author Correction: Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"28754903","year":"2017","title":"Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"}],"tags":[{"label":"pirenoxine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pirfenoxone","offLabel":[],"synonyms":["pirenoxine","pirfenoxone","pyrphenoxone"],"timeline":[],"approvals":[],"brandName":"Pirfenoxone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"pirenoxine","explanation":"Think of it like a key that unlocks a door in a cell. Pirfenoxone is thought to work by interacting with specific molecules inside the cell, which can affect how the cell grows, divides, and responds to its environment. However, the exact details of how it does this are still not well understood.","oneSentence":"Pirfenoxone is believed to modulate cellular processes, although its exact mechanism of action is unknown.","technicalDetail":"Pirfenoxone's mechanism of action is thought to involve the modulation of cellular signaling pathways, potentially through the inhibition of specific enzymes or the activation of transcription factors."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3476","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PIRENOXINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:25:26.891425","biosimilars":[],"competitors":[],"genericName":"pirenoxine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006157","UNII":"27L0EP6IZK","CHEBI":"CHEBI:32013","INN_ID":"5317","RXNORM":"228080","UMLSCUI":"C0752378","ChEMBL_ID":"CHEMBL1372341","KEGG_DRUG":"D01100","DRUGBANK_ID":"DB15945","PUBCHEM_CID":"4846","MESH_SUPPLEMENTAL_RECORD_UI":"C004580"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan 20","pmid":"41557063","title":"Hydrogen-rich saline treatment modulates proteomic profiles to mitigate cataract development in a N-methyl-N-nitrosourea-induced rat model.","journal":"International ophthalmology"},{"date":"2022 Aug 21","pmid":"36012695","title":"The Possible Positive Mechanisms of Pirenoxine in Cataract Formation.","journal":"International journal of molecular sciences"},{"date":"2021 Oct","pmid":"34708633","title":"Anti-cataract effects of Dajizhi (Euphorbium) eye drops on selenite-induced cataracts in rat.","journal":"Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan"},{"date":"2020 Apr 16","pmid":"32296100","title":"Author Correction: Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy.","journal":"Scientific reports"},{"date":"2017 Jul 28","pmid":"28754903","title":"Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy.","journal":"Scientific reports"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pirfenoxone, also known as Pirenoxine, is a small molecule drug in the pirenoxine class. Its exact target and mechanism of action are unknown, but it is believed to work by modulating cellular processes. Pirfenoxone is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. Further research is needed to determine its safety and efficacy. As a result, key safety considerations and potential side effects are currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}