{"id":"pipoxolan","rwe":[{"pmid":"32677756","year":"2020","title":"Pipoxolan suppresses the inflammatory factors of NF-κB, AP-1, and STATs, but activates the antioxidative factor Nrf2 in LPS-stimulated RAW 264.7 murine macrophage cells.","finding":"","journal":"Environmental toxicology","studyType":"Clinical Study"},{"pmid":"29061824","year":"2017","title":"Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Through Reactive Oxygen Species-mediated Apoptosis.","finding":"","journal":"Anticancer research","studyType":"Clinical Study"},{"pmid":"25899827","year":"2015","title":"Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2.","finding":"","journal":"Chemico-biological interactions","studyType":"Clinical Study"},{"pmid":"24086601","year":"2013","title":"Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2/9 and Ras/MEK/ERK signaling pathways.","finding":"","journal":"PloS one","studyType":"Clinical Study"},{"pmid":"24000748","year":"2013","title":"Kinetics investigation and determination of pipoxolan hydrochloride and its degradant using liquid chromatography.","finding":"","journal":"Journal of AOAC International","studyType":"Clinical Study"}],"tags":[{"label":"pipoxolan","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["pipoxolan"],"offLabel":[],"synonyms":["pipoxolan"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"pipoxolan","explanation":"Imagine your body's cells have locks on them, and PIPOXOLAN is a key that fits into one of those locks. When it binds to the lock, it triggers a series of events that ultimately lead to a therapeutic effect, such as reducing symptoms of a particular disease. However, the exact lock that PIPOXOLAN binds to and the events that follow are not well understood.","oneSentence":"PIPOXOLAN is a small molecule that works by interacting with a specific target to produce a therapeutic effect.","technicalDetail":"PIPOXOLAN is a pipoxolan, a class of small molecules that may interact with a specific protein or receptor to produce a therapeutic effect. The exact mechanism of action of PIPOXOLAN is unknown, but it may involve modulation of a signaling pathway or interaction with a specific enzyme."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2194","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PIPOXOLAN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PIPOXOLAN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:21:00.673090","biosimilars":[],"competitors":[],"genericName":"pipoxolan","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT05864716","phase":"NA","title":"Colonoscopic Probiotics Spray in Irritable Bowel Syndrome","status":"NOT_YET_RECRUITING","sponsor":"National Cheng-Kung University Hospital","startDate":"2024-10-01","conditions":["Effect of Drug"],"enrollment":66,"completionDate":"2026-04-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004154","UNII":"493GZJ5T6I","INN_ID":"2862","RXNORM":"33758","UMLSCUI":"C0071120","ChEMBL_ID":"CHEMBL2110645","KEGG_DRUG":"D07369","PUBCHEM_CID":"28932","MESH_SUPPLEMENTAL_RECORD_UI":"C000121"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2020 Dec","pmid":"32677756","title":"Pipoxolan suppresses the inflammatory factors of NF-κB, AP-1, and STATs, but activates the antioxidative factor Nrf2 in LPS-stimulated RAW 264.7 murine macrophage cells.","journal":"Environmental toxicology"},{"date":"2017 Nov","pmid":"29061824","title":"Pipoxolan Exhibits Antitumor Activity Toward Oral Squamous Cell Carcinoma Through Reactive Oxygen Species-mediated Apoptosis.","journal":"Anticancer research"},{"date":"2015 Jul 5","pmid":"25899827","title":"Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2.","journal":"Chemico-biological interactions"},{"date":"2013","pmid":"24086601","title":"Pipoxolan ameliorates cerebral ischemia via inhibition of neuronal apoptosis and intimal hyperplasia through attenuation of VSMC migration and modulation of matrix metalloproteinase-2/9 and Ras/MEK/ERK signaling pathways.","journal":"PloS one"},{"date":"2013 Jul-Aug","pmid":"24000748","title":"Kinetics investigation and determination of pipoxolan hydrochloride and its degradant using liquid chromatography.","journal":"Journal of AOAC International"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"PIPOXOLAN","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pipoxolan is a drug used in a clinical trial for the treatment of Irritable Bowel Syndrome (IBS) via a colonoscopic probiotics spray. The exact mechanism of action of Pipoxolan is not specified in the provided information, but it is being compared to oral administration of probiotics in the treatment of IBS.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}