{"id":"pimitespib","rwe":[{"pmid":"41785671","year":"2026","title":"Quality-of-life outcomes with pimitespib in patients with advanced gastrointestinal stromal tumor: results from the randomized, double-blind, placebo-controlled, phase III, CHAPTER-GIST-301 study.","finding":"","journal":"ESMO open","studyType":"Clinical Study"},{"pmid":"41440009","year":"2025","title":"Targeting Hsp90 in Cancer for 25 Years: Failure of Previous Clinical Trials and New Hope for Future Therapeutics.","finding":"","journal":"Cells","studyType":"Clinical Study"},{"pmid":"41264161","year":"2026","title":"Pooled safety analysis of pimitespib for the treatment of patients with advanced gastrointestinal stromal tumors.","finding":"","journal":"International journal of clinical oncology","studyType":"Clinical Study"},{"pmid":"41258483","year":"2026","title":"Efficacy and safety of pimitespib in gastrointestinal tumors.","finding":"","journal":"Surgery today","studyType":"Clinical Study"},{"pmid":"41087345","year":"2025","title":"In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance.","finding":"","journal":"Signal transduction and targeted therapy","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Heat shock protein HSP 90-beta","category":"target"},{"label":"HSP90AB1","category":"gene"},{"label":"HSP90AA1","category":"gene"},{"label":"Active","category":"status"},{"label":"Gastrointestinal stromal tumor","category":"indication"},{"label":"Taiho Pharmaceutical Co., Ltd","category":"company"}],"phase":"marketed","safety":{},"trials":[],"aliases":["TAS-116"],"company":"Taiho Pharmaceutical Co., Ltd","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Pimitespib","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:51:54.634875+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:51:59.669626+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pimitespib","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:52:00.038915+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL3661115/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:52:00.994092+00:00"}},"allNames":"jeselhy","offLabel":[],"synonyms":["pimitespib","jeselhy","TAS-116"],"timeline":[{"date":"2022-06-20","type":"positive","source":"DrugCentral","milestone":"PMDA approval (Taiho Pharmaceutical Co., Ltd)"}],"approvals":[{"date":"2022-06-20","orphan":false,"company":"TAIHO PHARMACEUTICAL CO., LTD","regulator":"PMDA"}],"brandName":"Jeselhy","ecosystem":[{"indication":"Gastrointestinal stromal tumor","otherDrugs":[{"name":"avapritinib","slug":"avapritinib","company":"Blueprint Medicines"},{"name":"imatinib","slug":"imatinib","company":"Novartis"},{"name":"regorafenib","slug":"regorafenib","company":"Bayer Hlthcare"},{"name":"ripretinib","slug":"ripretinib","company":"Deciphera Pharms"}],"globalPrevalence":1040000}],"mechanism":{"target":"Heat shock protein HSP 90-beta","targets":[{"gene":"HSP90AB1","source":"DrugCentral","target":"Heat shock protein HSP 90-beta","protein":"Heat shock protein HSP 90-beta"},{"gene":"HSP90AA1","source":"DrugCentral","target":"Heat shock protein HSP 90-alpha","protein":"Heat shock protein HSP 90-alpha"}],"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Jeselhy inhibits the ATPase activity of HSP 90-beta, disrupting its ability to facilitate protein folding and stability, which is critical for cancer cell survival and proliferation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5686","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=Pimitespib","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=Pimitespib","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:20:58.126962","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:52:02.968543+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"famotidine","drugSlug":"famotidine","fdaApproval":"1986-10-15","genericCount":54,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"formoterol","drugSlug":"formoterol","fdaApproval":"2001-02-16","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"midodrine","drugSlug":"midodrine","fdaApproval":"1996-09-06","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"primaquine","drugSlug":"primaquine","fdaApproval":"1952-01-23","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"terfenadine","drugSlug":"terfenadine","fdaApproval":"","relationship":"same-target"},{"drugName":"thiamine","drugSlug":"thiamine","fdaApproval":"1993-12-29","genericCount":20,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"genericName":"pimitespib","indications":{"approved":[{"name":"Gastrointestinal stromal tumor","source":"DrugCentral","snomedId":420120006,"regulator":"FDA","usPrevalence":null,"globalPrevalence":1040000,"prevalenceMethod":"curated","prevalenceSource":"Orphanet (European Medicines Agency[INST]_23623056[PMID])"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"famotidine","brandName":"famotidine","genericName":"famotidine","approvalYear":"1986","relationship":"same-target"},{"drugId":"formoterol","brandName":"formoterol","genericName":"formoterol","approvalYear":"2001","relationship":"same-target"},{"drugId":"midodrine","brandName":"midodrine","genericName":"midodrine","approvalYear":"1996","relationship":"same-target"},{"drugId":"primaquine","brandName":"primaquine","genericName":"primaquine","approvalYear":"1952","relationship":"same-target"},{"drugId":"terfenadine","brandName":"terfenadine","genericName":"terfenadine","approvalYear":"","relationship":"same-target"},{"drugId":"thiamine","brandName":"thiamine","genericName":"thiamine","approvalYear":"1993","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT05245968","phase":"PHASE1","title":"A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Taiho Pharmaceutical Co., Ltd.","startDate":"2021-12-01","conditions":["Gastrointestinal Stromal Tumors"],"enrollment":78,"completionDate":"2026-12"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"PLO044MUDZ","INN_ID":"11079","UMLSCUI":"C5418185","chemblId":"CHEMBL3661115","ChEMBL_ID":"CHEMBL3661115","KEGG_DRUG":"D11920","DRUGBANK_ID":"DB14876","PUBCHEM_CID":"67501411","IUPHAR_LIGAND_ID":"12284","MESH_SUPPLEMENTAL_RECORD_UI":"C000596495"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"present","companyName":"Taiho Pharmaceutical Co., Ltd","relationship":"Current Owner"}],"publicationCount":36,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar","pmid":"41785671","title":"Quality-of-life outcomes with pimitespib in patients with advanced gastrointestinal stromal tumor: results from the randomized, double-blind, placebo-controlled, phase III, CHAPTER-GIST-301 study.","journal":"ESMO open"},{"date":"2025 Dec 15","pmid":"41440009","title":"Targeting Hsp90 in Cancer for 25 Years: Failure of Previous Clinical Trials and New Hope for Future Therapeutics.","journal":"Cells"},{"date":"2026 Jan","pmid":"41264161","title":"Pooled safety analysis of pimitespib for the treatment of patients with advanced gastrointestinal stromal tumors.","journal":"International journal of clinical oncology"},{"date":"2026 Feb","pmid":"41258483","title":"Efficacy and safety of pimitespib in gastrointestinal tumors.","journal":"Surgery today"},{"date":"2025 Oct 15","pmid":"41087345","title":"In vivo self-assembled nano-PROTAC for the dual degradation of AR and HSP90 to overcome castration-resistant prostate cancer resistance.","journal":"Signal transduction and targeted therapy"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Taiho Pharmaceutical Co., Ltd","companyId":"taiho-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"JP","regulator":"PMDA","status":"approved","approval_date":"2022-06-20T00:00:00.000Z","mah":"TAIHO PHARMACEUTICAL CO., LTD","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:52:02.968543+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}