{"id":"pimethixene","rwe":[],"tags":[{"label":"pimethixene","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histone-lysine N-methyltransferase SETD7","category":"target"},{"label":"SETD7","category":"gene"},{"label":"R06AX23","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"calmixen","offLabel":[],"synonyms":["pimethixene","calmixen","mepithiathene","pimetixene","pimethixene maleate"],"timeline":[],"approvals":[],"brandName":"Calmixen","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 2A, Histone-lysine N-methyltransferase SETD7, Transcriptional activator protein luxR","targets":[{"gene":"SETD7","source":"DrugCentral","target":"Histone-lysine N-methyltransferase SETD7","protein":"Histone-lysine N-methyltransferase SETD7"}],"modality":"Small Molecule","drugClass":"pimethixene","explanation":"Think of gene regulation like a light switch. Histone-lysine N-methyltransferase SETD7 is like a dimmer switch that adjusts how much light is turned on or off. Calmixen flips the switch to a different setting, which can affect how genes are expressed and potentially treat certain diseases.","oneSentence":"Calmixen works by inhibiting the activity of Histone-lysine N-methyltransferase SETD7, an enzyme involved in gene regulation.","technicalDetail":"Calmixen acts as a competitive inhibitor of Histone-lysine N-methyltransferase SETD7, preventing the enzyme from adding methyl groups to histone proteins and thereby altering chromatin structure and gene expression."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2169","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PIMETHIXENE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:20:12.749148","biosimilars":[],"competitors":[{"drugName":"cyproheptadine","drugSlug":"cyproheptadine","fdaApproval":"1961-10-17","genericCount":31,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"antazoline","drugSlug":"antazoline","fdaApproval":"1990-04-30","relationship":"same-class"},{"drugName":"triprolidine","drugSlug":"triprolidine","fdaApproval":"1983-05-17","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"azatadine","drugSlug":"azatadine","fdaApproval":"1977-03-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"astemizole","drugSlug":"astemizole","fdaApproval":"1988-12-31","relationship":"same-class"},{"drugName":"terfenadine","drugSlug":"terfenadine","fdaApproval":"","relationship":"same-class"},{"drugName":"loratadine","drugSlug":"loratadine","fdaApproval":"1993-04-12","genericCount":29,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ketotifen","drugSlug":"ketotifen","fdaApproval":"1999-07-02","patentExpiry":"Mar 27, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"acrivastine","drugSlug":"acrivastine","fdaApproval":"1994-03-25","relationship":"same-class"},{"drugName":"azelastine","drugSlug":"azelastine","fdaApproval":"1996-11-01","patentExpiry":"Jun 4, 2028","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"epinastine","drugSlug":"epinastine","fdaApproval":"2003-10-16","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fexofenadine","drugSlug":"fexofenadine","fdaApproval":"1996-07-25","patentExpiry":"Aug 2, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"desloratadine","drugSlug":"desloratadine","fdaApproval":"2001-12-21","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"pimethixene","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cyproheptadine","brandName":"cyproheptadine","genericName":"cyproheptadine","approvalYear":"1961","relationship":"same-class"},{"drugId":"antazoline","brandName":"antazoline","genericName":"antazoline","approvalYear":"1990","relationship":"same-class"},{"drugId":"triprolidine","brandName":"triprolidine","genericName":"triprolidine","approvalYear":"1983","relationship":"same-class"},{"drugId":"azatadine","brandName":"azatadine","genericName":"azatadine","approvalYear":"1977","relationship":"same-class"},{"drugId":"astemizole","brandName":"astemizole","genericName":"astemizole","approvalYear":"1988","relationship":"same-class"},{"drugId":"terfenadine","brandName":"terfenadine","genericName":"terfenadine","approvalYear":"","relationship":"same-class"},{"drugId":"loratadine","brandName":"loratadine","genericName":"loratadine","approvalYear":"1993","relationship":"same-class"},{"drugId":"ketotifen","brandName":"ketotifen","genericName":"ketotifen","approvalYear":"1999","relationship":"same-class"},{"drugId":"acrivastine","brandName":"acrivastine","genericName":"acrivastine","approvalYear":"1994","relationship":"same-class"},{"drugId":"azelastine","brandName":"azelastine","genericName":"azelastine","approvalYear":"1996","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"005718","UNII":"T46J20J26F","CHEBI":"CHEBI:94787","INN_ID":"1739","RXNORM":"33712","UMLSCUI":"C0071069","ChEMBL_ID":"CHEMBL152408","KEGG_DRUG":"D07406","DRUGBANK_ID":"DB13292","PUBCHEM_CID":"4822","SECONDARY_CAS_RN":"13187-06-9","MESH_SUPPLEMENTAL_RECORD_UI":"C004327"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R06AX23","allCodes":["R06AX23"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Calmixen (Pimethixene) is a small molecule drug that targets Histone-lysine N-methyltransferase SETD7. It is classified as a pimethixene, but its commercial status and approved indications are unknown. The mechanism of action and pharmacokinetic properties of Calmixen are also not well-documented. Further research is needed to understand its potential therapeutic applications and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}