{"id":"picotamide","rwe":[{"pmid":"41800570","year":"2026","title":"Distinct Thromboxane A₂-Dependent Pathways Regulate Arachidonic Acid-Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition.","finding":"","journal":"Journal of cellular physiology","studyType":"Clinical Study"},{"pmid":"38158114","year":"2024","title":"Chymase-independent vascular Ang-(1-12)/Ang II pathway and TXA(2) generation are involved in endothelial dysfunction in the murine model of heart failure.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"},{"pmid":"34500186","year":"2021","title":"Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents.","finding":"","journal":"Bioorganic & medicinal chemistry","studyType":"Clinical Study"},{"pmid":"33929093","year":"2021","title":"Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries.","finding":"","journal":"Pharmacology research & perspectives","studyType":"Clinical Study"},{"pmid":"32819249","year":"2021","title":"Efficacy and Safety of Antiplatelet Therapies in Symptomatic Peripheral Artery Disease: A Systematic Review and Network Meta-Analysis.","finding":"","journal":"Current vascular pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"picotamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"B01AC03","category":"atc"},{"label":"Active","category":"status"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Platelet Aggregation Inhibitors","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["picotamide","picotamide monohydrate","picotamide hydrate"],"offLabel":[],"synonyms":["picotamide","picotamide monohydrate","picotamide hydrate"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"picotamide","explanation":"Think of it like a traffic jam in your blood vessels. Thromboxane A2 is like a traffic cop that tells your blood vessels to close up and stop blood flow. Picotamide is like a traffic cop that tells the other traffic cop to stand down, keeping your blood vessels open and improving blood flow.","oneSentence":"Picotamide works by inhibiting the action of thromboxane A2, a substance that promotes blood clotting.","technicalDetail":"Picotamide exerts its effects by competitively inhibiting the binding of thromboxane A2 to its receptor, thereby reducing platelet aggregation and vasoconstriction."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2161","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=picotamide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:20:25.568287","biosimilars":[],"competitors":[{"drugName":"clopidogrel","drugSlug":"clopidogrel","fdaApproval":"1997-11-17","genericCount":23,"patentStatus":"Off-patent — generic 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available","relationship":"same-class"},{"drugName":"ticagrelor","drugSlug":"ticagrelor","fdaApproval":"2011-07-20","patentExpiry":"Oct 17, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cangrelor","drugSlug":"cangrelor","fdaApproval":"2015-06-22","patentExpiry":"Nov 10, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"vorapaxar","drugSlug":"vorapaxar","fdaApproval":"2014-05-08","patentExpiry":"Dec 23, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"selexipag","drugSlug":"selexipag","fdaApproval":"2015-12-21","patentExpiry":"Oct 31, 2026","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"picotamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clopidogrel","brandName":"clopidogrel","genericName":"clopidogrel","approvalYear":"1997","relationship":"same-class"},{"drugId":"ticlopidine","brandName":"ticlopidine","genericName":"ticlopidine","approvalYear":"1991","relationship":"same-class"},{"drugId":"acetylsalicylic-acid","brandName":"acetylsalicylic acid","genericName":"acetylsalicylic acid","approvalYear":"1950","relationship":"same-class"},{"drugId":"dipyridamole","brandName":"dipyridamole","genericName":"dipyridamole","approvalYear":"1961","relationship":"same-class"},{"drugId":"epoprostenol","brandName":"epoprostenol","genericName":"epoprostenol","approvalYear":"1995","relationship":"same-class"},{"drugId":"iloprost","brandName":"iloprost","genericName":"iloprost","approvalYear":"2004","relationship":"same-class"},{"drugId":"abciximab","brandName":"abciximab","genericName":"abciximab","approvalYear":"1993","relationship":"same-class"},{"drugId":"eptifibatide","brandName":"eptifibatide","genericName":"eptifibatide","approvalYear":"1998","relationship":"same-class"},{"drugId":"tirofiban","brandName":"tirofiban","genericName":"tirofiban","approvalYear":"1998","relationship":"same-class"},{"drugId":"treprostinil","brandName":"treprostinil","genericName":"treprostinil","approvalYear":"2002","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"654G2VCI4Q","CHEBI":"CHEBI:93175","UMLSCUI":"C0071043","ChEMBL_ID":"CHEMBL1257015","KEGG_DRUG":"D07140","DRUGBANK_ID":"DB13327","PUBCHEM_CID":"4814","IUPHAR_LIGAND_ID":"11379","SECONDARY_CAS_RN":"80530-63-8","MESH_SUPPLEMENTAL_RECORD_UI":"C011581"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":110,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"B01AC03","allCodes":["B01AC03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar","pmid":"41800570","title":"Distinct Thromboxane A₂-Dependent Pathways Regulate Arachidonic Acid-Triggered VASP Phosphorylation at Ser239 and Ser157 in Human Platelets: Real-Time Visualization Reveals Superior Antithrombotic Efficacy by Targeting Thromboxane A₂ Signaling over Cyclooxygenase Inhibition.","journal":"Journal of cellular physiology"},{"date":"2024 Mar 5","pmid":"38158114","title":"Chymase-independent vascular Ang-(1-12)/Ang II pathway and TXA(2) generation are involved in endothelial dysfunction in the murine model of heart failure.","journal":"European journal of pharmacology"},{"date":"2021 Sep 15","pmid":"34500186","title":"Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents.","journal":"Bioorganic & medicinal chemistry"},{"date":"2021 May","pmid":"33929093","title":"Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries.","journal":"Pharmacology research & perspectives"},{"date":"2021","pmid":"32819249","title":"Efficacy and Safety of Antiplatelet Therapies in Symptomatic Peripheral Artery Disease: A Systematic Review and Network Meta-Analysis.","journal":"Current vascular pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"picotamide","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Picotamide is a small molecule drug in the picotamide class, originally developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are unknown. It is not FDA-approved for any indications. The commercial status of picotamide is unclear, and it is unknown whether it is patented or available as a generic. Key safety considerations are also unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}