{"id":"pico-salax","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1741134","moleculeType":"Small molecule","molecularWeight":"437.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sodium picosulfate is a prodrug that is metabolized by colonic bacteria into bis-(p-hydroxyphenyl)-pyridyl-methane, which acts as a stimulant laxative on the colon. Magnesium citrate acts as an osmotic agent, drawing water into the intestinal lumen to increase stool bulk and promote evacuation. Together, these components provide rapid and effective bowel cleansing prior to diagnostic or surgical procedures.","oneSentence":"Pico-Salax is a bowel cleansing agent that combines sodium picosulfate with magnesium citrate to stimulate intestinal motility and osmotically draw fluid into the colon, evacuating bowel contents.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:33:50.494Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bowel cleansing prior to colonoscopy"},{"name":"Bowel cleansing prior to barium enema or other colorectal procedures"}]},"trialDetails":[{"nctId":"NCT00380497","phase":"PHASE4","title":"Pico-Salax Versus Poly-Ethylene Glycol for Bowel Cleanout Before Colonoscopy in Children","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2006-09","conditions":"Colonoscopy","enrollment":83}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Pico-Salax®","genericName":"Pico-Salax®","companyName":"The Hospital for Sick Children","companyId":"the-hospital-for-sick-children","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pico-Salax is a small molecule used as a bowel cleanser before colonoscopy. It is a competitor to PEG-Lyte in this application, as demonstrated in a clinical trial comparing the two for bowel cleanout in children.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}