{"id":"phytonadione-vitamin-k1","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypersensitivity reactions (flushing, dyspnea, chest pain)"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Transient flushing or warmth"}]},"_chembl":null,"_dailymed":{"setId":"c204c720-88d3-a6d6-e053-2a95a90a3de5","title":"VITAMIN K1 - PHYTONADIONE INJECTION, EMULSION [HF ACQUISITION CO LLC, DBA HEALTHFIRST]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin K1 is essential for the post-translational carboxylation of glutamic acid residues on clotting factors II, VII, IX, and X, as well as proteins C and S. This carboxylation allows these proteins to bind calcium and phospholipids, which is necessary for their coagulant activity. Phytonadione is used to reverse warfarin and other vitamin K antagonist anticoagulants, and to treat vitamin K deficiency bleeding.","oneSentence":"Phytonadione (Vitamin K1) acts as a cofactor for gamma-glutamyl carboxylase, enabling the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) in the liver.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:13.004Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reversal of warfarin-induced anticoagulation"},{"name":"Treatment of vitamin K deficiency bleeding (including hemorrhagic disease of the newborn)"},{"name":"Prophylaxis of vitamin K deficiency in patients at risk"}]},"trialDetails":[{"nctId":"NCT04752813","phase":"PHASE2","title":"A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)","status":"ACTIVE_NOT_RECRUITING","sponsor":"BPGbio","startDate":"2022-08-22","conditions":"Glioblastoma, Glioblastoma 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AG","startDate":"2007-01","conditions":"Osteoporosis","enrollment":70}],"_emaApprovals":[],"_faersSignals":[{"count":2,"reaction":"BACTERAEMIA"},{"count":2,"reaction":"HEPATIC FAILURE"},{"count":2,"reaction":"SEPSIS"},{"count":1,"reaction":"ACUTE KIDNEY INJURY"},{"count":1,"reaction":"BLOOD CREATININE INCREASED"},{"count":1,"reaction":"BLOOD FIBRINOGEN DECREASED"},{"count":1,"reaction":"BLOOD UREA INCREASED"},{"count":1,"reaction":"FALL"},{"count":1,"reaction":"HEPATITIS FULMINANT"},{"count":1,"reaction":"HEPATORENAL SYNDROME"}],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Phytonadione (Vitamin K1)","genericName":"Phytonadione (Vitamin K1)","companyName":"St. Joseph's Healthcare Hamilton","companyId":"st-joseph-s-healthcare-hamilton","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phytonadione (Vitamin K1) acts as a cofactor for gamma-glutamyl carboxylase, enabling the synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) in the liver. Used for Reversal of warfarin-induced anticoagulation, Treatment of vitamin K deficiency bleeding (including hemorrhagic disease of the newborn), Prophylaxis of vitamin K deficiency in patients at risk.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}