{"id":"phyt-decandra-melissa-offic","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phytolacca decandra (pokeweed) contains saponins and lectins with potential immunostimulatory properties, while Melissa officinalis (lemon balm) provides polyphenols and rosmarinic acid with antioxidant and anti-inflammatory activity. The combination may work synergistically to modulate immune responses and reduce inflammatory markers, though the exact mechanism in human disease remains incompletely characterized.","oneSentence":"A herbal combination of Phytolacca decandra and Melissa officinalis that likely exerts anti-inflammatory and immunomodulatory effects through polyphenolic and volatile oil constituents.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:26:16.177Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Phase 3 indication not publicly specified; likely immune or inflammatory condition based on constituent properties"}]},"trialDetails":[{"nctId":"NCT02870543","phase":"PHASE3","title":"Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism","status":"UNKNOWN","sponsor":"Universidade Federal do Rio de Janeiro","startDate":"2014-09","conditions":"Nocturnal Bruxism","enrollment":52}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["homeopathic medicine complex"],"phase":"phase_3","status":"active","brandName":"Phyt.decandra + Melissa offic.","genericName":"Phyt.decandra + Melissa offic.","companyName":"Universidade Federal do Rio de Janeiro","companyId":"universidade-federal-do-rio-de-janeiro","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A herbal combination of Phytolacca decandra and Melissa officinalis that likely exerts anti-inflammatory and immunomodulatory effects through polyphenolic and volatile oil constituents. Used for Phase 3 indication not publicly specified; likely immune or inflammatory condition based on constituent properties.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}