{"id":"physiological-seawater-adjustable-nasal-irrigator","safety":{"commonSideEffects":[{"rate":null,"effect":"Mild nasal irritation"},{"rate":null,"effect":"Temporary discomfort during irrigation"},{"rate":null,"effect":"Rare epistaxis if pressure too high"}]},"_chembl":{"chemblId":"CHEMBL3219616","moleculeType":"Small molecule","molecularWeight":"426.58"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This device delivers sterile, physiological seawater (isotonic saline) to the nasal cavity at adjustable pressure levels to mechanically remove mucus, allergens, pathogens, and inflammatory debris. The isotonic formulation maintains osmotic balance with nasal mucosa, reducing irritation while promoting mucosal hydration and clearance. It is a non-pharmacological, mechanical intervention rather than a drug with a molecular mechanism.","oneSentence":"A physiological saline nasal irrigator that mechanically cleanses and moisturizes nasal passages using adjustable-pressure delivery of isotonic seawater solution.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:00:17.374Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nasal congestion and sinus irrigation"},{"name":"Allergic rhinitis symptom relief"},{"name":"Post-nasal drip management"},{"name":"Nasal hygiene and mucus clearance"}]},"trialDetails":[{"nctId":"NCT07308015","phase":"PHASE4","title":"Clinical Study on the Treatment of Rhinitis Sicca With Sodium Hyaluronate Adjustable Nasal Irrigator","status":"RECRUITING","sponsor":"China-Japan Union Hospital","startDate":"2025-06-16","conditions":"Rhinitis Sicca","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Physiological seawater adjustable nasal irrigator","genericName":"Physiological seawater adjustable nasal irrigator","companyName":"China-Japan Union Hospital","companyId":"china-japan-union-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A physiological saline nasal irrigator that mechanically cleanses and moisturizes nasal passages using adjustable-pressure delivery of isotonic seawater solution. Used for Nasal congestion and sinus irrigation, Allergic rhinitis symptom relief, Post-nasal drip management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}