{"id":"phyllanthus-niruri","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":{"setId":"12b8ef27-179e-4920-bcd3-856daada1a6a","title":"SP (MATICO, SARSAPARILLA (SMILAX REGELII), THUJA OCCIDENTALIS, UNCARIA TOMENTOSA, PHYLLANTHUS NIRURI, POLYGONUM CUSPIDATUM) LIQUID [CHI RESEARCH, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The plant contains lignans, flavonoids, and other polyphenolic compounds that reduce oxidative stress and inflammation in hepatic tissue. These constituents may inhibit viral replication and support liver function through antioxidant mechanisms. Traditional use suggests benefits in managing liver disorders and kidney stone formation, though the exact molecular targets remain incompletely characterized.","oneSentence":"Phyllanthus niruri is a medicinal plant that exhibits hepatoprotective, anti-inflammatory, and antioxidant properties through multiple phytochemical constituents.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T06:18:02.224Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Liver support and hepatoprotection"},{"name":"Kidney stone prevention and management"},{"name":"Viral hepatitis support"}]},"trialDetails":[{"nctId":"NCT06636760","phase":"NA","title":"Efficacy and Immunomodulator Impact of Herbal Combination on COVID-19 Patients Recovery","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2021-08-27","conditions":"COVID 19","enrollment":66},{"nctId":"NCT05206058","phase":"","title":"To Exam the Effects of Phyllanthus Niruri Extracts on Human Neutrophils","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2022-01-01","conditions":"Neutrophil, Phyllanthus Abnormis Poisoning","enrollment":240},{"nctId":"NCT03503708","phase":"NA","title":"Herbal Supplements for Improvement of Liver Function in Participants With Alcoholic Liver Disease","status":"NOT_YET_RECRUITING","sponsor":"Composite Interceptive Med Science","startDate":"2018-05-30","conditions":"Alcoholic Liver Disease","enrollment":40},{"nctId":"NCT02899130","phase":"NA","title":"Effect of Polyherbal Formulation in Chronic Inactive Carriers of Hepatitis B Virus","status":"UNKNOWN","sponsor":"Composite Interceptive Med Science","startDate":"2016-10","conditions":"Chronic Hepatitis B","enrollment":80},{"nctId":"NCT02107469","phase":"NA","title":"A Study of Phyllanthus Niruri and Sida Cordifolia in Diabetic Peripheral Polyneuropathy","status":"COMPLETED","sponsor":"Rosenberg European Academy of Ayurveda","startDate":"2014-06","conditions":"Diabetic Polyneuropathy, Diabetic Neuralgia, Diabetic Neuropathies","enrollment":98},{"nctId":"NCT02669641","phase":"PHASE4","title":"Complex Imaging Assessment of Steatosis","status":"UNKNOWN","sponsor":"University of Medicine and Pharmacy Craiova","startDate":"2016-01","conditions":"Fatty Liver","enrollment":50},{"nctId":"NCT01680003","phase":"PHASE2","title":"Hepar-P Study to Evaluate the Safety and Efficacy of a Standardised Extract of Phyllanthus Niruri for the Treatment of Non-alcoholic Fatty Liver Disease","status":"UNKNOWN","sponsor":"Nova Laboratories Sdn Bhd","startDate":"2012-09","conditions":"Non-alcoholic Fatty Liver Disease","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":250,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Phyllanthus amarus","Bhumyamalaki","Tamalaki"],"phase":"marketed","status":"active","brandName":"Phyllanthus niruri","genericName":"Phyllanthus niruri","companyName":"Rosenberg European Academy of Ayurveda","companyId":"rosenberg-european-academy-of-ayurveda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phyllanthus niruri is a medicinal plant that exhibits hepatoprotective, anti-inflammatory, and antioxidant properties through multiple phytochemical constituents. Used for Liver support and hepatoprotection, Kidney stone prevention and management, Viral hepatitis support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}