{"id":"phrenic-nerve-block-with-ropivacaine","brandName":"Phrenic nerve block with Ropivacaine","genericName":"Phrenic nerve block with Ropivacaine","companyId":"odense-university-hospital","companyName":"Odense University Hospital","phase":"marketed","status":"active","modality":"Small molecule","aliases":["Naropin"],"developmentCodes":[],"firstApprovalDate":null,"firstApprovalCountry":null,"aiSummary":"Ropivacaine, a local anesthetic, is used off-label for phrenic nerve blocks to manage postoperative shoulder pain. Clinical trials are ongoing to evaluate its efficacy and safety in various surgical contexts, including VATS and lobectomy.","enrichmentLevel":3,"visitCount":0,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ropivacaine is a local anesthetic that works by inhibiting voltage-gated sodium channels in nerve cell membranes, preventing depolarization and action potential propagation. When administered as a phrenic nerve block, it reversibly anesthetizes the phrenic nerve, which innervates the diaphragm, resulting in temporary diaphragmatic paralysis. This effect is used clinically to manage conditions such as intractable hiccups or to facilitate certain surgical procedures.","oneSentence":"Ropivacaine blocks sodium channels in nerve fibers when injected around the phrenic nerve, temporarily interrupting nerve signal transmission to paralyze the diaphragm.","_ai_confidence":"medium"},"administration":{},"safety":{"commonSideEffects":[{"rate":null,"effect":"Temporary diaphragmatic paralysis"},{"rate":null,"effect":"Hoarseness or voice changes"},{"rate":null,"effect":"Shoulder pain"},{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Systemic toxicity from local anesthetic (rare)"}]},"trials":[],"indications":{"approved":[{"name":"Phrenic nerve block for diaphragmatic paralysis (e.g., intractable hiccups, surgical facilitation)"}]},"commercial":null,"patents":[],"timeline":[],"rwe":[],"competitors":[],"ownershipHistory":[],"trialDetails":[],"genericFilers":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"labelChanges":[],"nice":null,"revenue":null,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}