{"id":"phosphate-enema-kleen-enema","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Rectal irritation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Electrolyte imbalance (with repeated use)"}]},"_chembl":{"chemblId":"CHEMBL2107648","moleculeType":"Small molecule","molecularWeight":"460.67"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The sodium phosphate and dibasic sodium phosphate salts in the enema create an osmotic gradient that pulls fluid into the intestinal lumen, increasing stool bulk and water content. This mechanical distension of the colon triggers peristalsis and defecation reflex, providing rapid bowel evacuation typically within 2–15 minutes.","oneSentence":"Phosphate enema works by drawing water into the colon through osmotic action, softening stool and stimulating bowel evacuation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:05.520Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation and bowel evacuation"},{"name":"Pre-procedure bowel cleansing (colonoscopy, sigmoidoscopy)"}]},"trialDetails":[{"nctId":"NCT02386904","phase":"PHASE4","title":"Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy","status":"UNKNOWN","sponsor":"Nabiqasim Industries (Pvt) Ltd","startDate":"2015-03","conditions":"Irritable Bowel Syndrome","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Brand name is Kleen® Enema"],"phase":"marketed","status":"active","brandName":"Phosphate Enema (Kleen® Enema)","genericName":"Phosphate Enema (Kleen® Enema)","companyName":"Nabiqasim Industries (Pvt) Ltd","companyId":"nabiqasim-industries-pvt-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phosphate enema works by drawing water into the colon through osmotic action, softening stool and stimulating bowel evacuation. Used for Constipation and bowel evacuation, Pre-procedure bowel cleansing (colonoscopy, sigmoidoscopy).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}