{"id":"phosphate-and-betamethasone-acetate-2-ml","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (pain, swelling, erythema)"},{"rate":null,"effect":"Transient hyperglycemia"},{"rate":null,"effect":"Systemic corticosteroid effects with repeated or high-dose use (HPA axis suppression, immunosuppression)"},{"rate":null,"effect":"Infection risk at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Betamethasone acetate is a synthetic glucocorticoid that enters cells and binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene expression. This results in decreased production of inflammatory mediators (cytokines, chemokines, adhesion molecules) and suppression of immune cell activation and migration. The phosphate salt formulation enhances solubility and allows for parenteral administration, typically as an intra-articular or soft-tissue injection.","oneSentence":"Betamethasone acetate is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:24.771Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Intra-articular injection for inflammatory arthritis and joint inflammation"},{"name":"Soft-tissue injection for bursitis, tendinitis, and localized inflammatory conditions"},{"name":"Dermatologic inflammatory conditions"}]},"trialDetails":[{"nctId":"NCT06882603","phase":"NA","title":"Efficacy of Corticosteroid Injection and Nerve Hydrodissection in Carpal Tunnel Syndrome","status":"RECRUITING","sponsor":"Kirsehir Ahi Evran Universitesi","startDate":"2025-10-14","conditions":"Carpal Tunnel Syndrome (CTS)","enrollment":90},{"nctId":"NCT05698966","phase":"NA","title":"Low Dose Antenatal Corticosteroids for Late Preterm Delivery","status":"RECRUITING","sponsor":"Rambam Health Care Campus","startDate":"2022-01-01","conditions":"Respiratory Morbidity, Preterm Labor","enrollment":1510},{"nctId":"NCT04976816","phase":"PHASE2, PHASE3","title":"Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid Eye Disease","status":"COMPLETED","sponsor":"Assiut University","startDate":"2021-12-01","conditions":"Thyroid Eye Disease","enrollment":92},{"nctId":"NCT01222247","phase":"PHASE3","title":"Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial","status":"COMPLETED","sponsor":"The George Washington University Biostatistics Center","startDate":"2010-10","conditions":"Pregnancy, Respiratory Distress Syndrome, Pregnancy Outcomes","enrollment":2831},{"nctId":"NCT05058209","phase":"PHASE4","title":"Effect of ZILRETTA Versus CELESTONE on Quality of Life, Pain, Neuromuscular Function, and Physical Performance","status":"COMPLETED","sponsor":"ROC Foundation","startDate":"2020-11-30","conditions":"Osteoarthritis, Knee","enrollment":20},{"nctId":"NCT03240783","phase":"PHASE2","title":"A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain","status":"UNKNOWN","sponsor":"St George Hospital, Australia","startDate":"2017-07-08","conditions":"Acute Sciatica","enrollment":60},{"nctId":"NCT00436969","phase":"PHASE3","title":"ORTHOVISC Shoulder Osteoarthritis Study","status":"COMPLETED","sponsor":"DePuy Mitek","startDate":"2006-12","conditions":"Glenohumeral Osteoarthritis","enrollment":274},{"nctId":"NCT02652884","phase":"PHASE4","title":"Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy","status":"UNKNOWN","sponsor":"Hospital Italiano de Buenos Aires","startDate":"2016-01","conditions":"Transient Hypoparathyroidism","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["cronodose"],"phase":"marketed","status":"active","brandName":"phosphate and betamethasone acetate, 2 mL.","genericName":"phosphate and betamethasone acetate, 2 mL.","companyName":"Hospital Italiano de Buenos Aires","companyId":"hospital-italiano-de-buenos-aires","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Betamethasone acetate is a corticosteroid that suppresses inflammatory and immune responses by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Intra-articular injection for inflammatory arthritis and joint inflammation, Soft-tissue injection for bursitis, tendinitis, and localized inflammatory conditions, Dermatologic inflammatory conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}