{"id":"phmb-0-08","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":{"chemblId":"CHEMBL78771","moleculeType":"Small molecule","molecularWeight":"338.71"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"PHMB is a quaternary ammonium compound that has been shown to exhibit broad-spectrum antimicrobial activity against bacteria, viruses, and fungi. It is thought to exert its effects by interacting with the cell membrane of microorganisms, ultimately leading to cell lysis and death.","oneSentence":"PHMB is an antimicrobial agent that works by disrupting the cell membrane of microorganisms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:51:10.087Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of blepharitis"}]},"trialDetails":[{"nctId":"NCT07195864","phase":"","title":"Retrospective Chart Review of Patients With Acanthamoeba Keratitis Who Have Received 0.8 mg/mL Polihexanide as Part of the \"Medicines in Special Situations\" (Medicamentos en Situaciones Especiales) Program in Spain.","status":"RECRUITING","sponsor":"SIFI SpA","startDate":"2025-10-30","conditions":"Acanthamoeba Keratitis","enrollment":24},{"nctId":"NCT03274895","phase":"PHASE3","title":"Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis","status":"COMPLETED","sponsor":"SIFI SpA","startDate":"2017-08-13","conditions":"Acanthamoeba Keratitis","enrollment":135},{"nctId":"NCT02506257","phase":"PHASE1","title":"Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects","status":"COMPLETED","sponsor":"SIFI SpA","startDate":"2015-11","conditions":"Acanthamoeba Keratitis","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Polihexanide 0.8 mg/ml"],"phase":"phase_3","status":"active","brandName":"PHMB 0.08%","genericName":"PHMB 0.08%","companyName":"SIFI SpA","companyId":"sifi-spa","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PHMB is an antimicrobial agent that works by disrupting the cell membrane of microorganisms. Used for Treatment of blepharitis.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}