{"id":"phloroglucin-flospan","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phloroglucin reduces smooth muscle contractions in the gastrointestinal and biliary tracts by blocking phosphodiesterase enzymes and interfering with calcium-dependent muscle contraction mechanisms. This leads to decreased spasm and pain in conditions affecting the digestive system. The drug has been used clinically for decades, particularly in Europe and Asia, for symptomatic relief of abdominal pain and cramping.","oneSentence":"Phloroglucin acts as a smooth muscle relaxant and antispasmodic agent by inhibiting phosphodiesterase and modulating calcium channels in visceral smooth muscle.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:39.012Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Abdominal pain and cramping associated with functional gastrointestinal disorders"},{"name":"Biliary colic and spasm"}]},"trialDetails":[{"nctId":"NCT03342118","phase":"PHASE3","title":"Effect of Oral Phloroglucin (Flospan®) as Premedication of Non-sedative Diagnostic Esophagogastroduodenoscopy","status":"COMPLETED","sponsor":"Keimyung University Dongsan Medical Center","startDate":"2017-09-21","conditions":"Anti-spasmodics, Gastric Peristalsis, Non-sedative Endoscopy","enrollment":140}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Phloroglucin(Flospan®)","genericName":"Phloroglucin(Flospan®)","companyName":"Keimyung University Dongsan Medical Center","companyId":"keimyung-university-dongsan-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phloroglucin acts as a smooth muscle relaxant and antispasmodic agent by inhibiting phosphodiesterase and modulating calcium channels in visceral smooth muscle. Used for Abdominal pain and cramping associated with functional gastrointestinal disorders, Biliary colic and spasm.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}