{"id":"phenylmercuric-nitrate","rwe":[],"tags":[{"label":"phenylmercuric nitrate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D09AA04","category":"atc"},{"label":"Active","category":"status"},{"label":"Hemorrhoids","category":"indication"},{"label":"Proctitis","category":"indication"},{"label":"Pruritus ani","category":"indication"},{"label":"Rectal pain","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["phenylmercuric nitrate"],"offLabel":[],"synonyms":["phenylmercuric nitrate"],"timeline":[],"approvals":[],"ecosystem":[{"indication":"Hemorrhoids","otherDrugs":[{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"ferric oxide","slug":"ferric-oxide","company":""},{"name":"hydrocortisone","slug":"hydrocortisone","company":"Merck"},{"name":"hydrocortisone acetate","slug":"hydrocortisone-acetate","company":"Merck"}],"globalPrevalence":null},{"indication":"Proctitis","otherDrugs":[{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"ferric oxide","slug":"ferric-oxide","company":""},{"name":"hydrocortisone","slug":"hydrocortisone","company":"Merck"},{"name":"phenylephrine","slug":"phenylephrine","company":"Ani Pharms"}],"globalPrevalence":2800000},{"indication":"Pruritus ani","otherDrugs":[{"name":"alclometasone dipropionate","slug":"alclometasone-dipropionate","company":""},{"name":"amcinonide","slug":"amcinonide","company":"Astellas"},{"name":"ammonium lactate","slug":"ammonium-lactate","company":"Ranbaxy"},{"name":"benzoyl peroxide","slug":"benzoyl-peroxide","company":"Valeant Intl"}],"globalPrevalence":null},{"indication":"Rectal pain","otherDrugs":[{"name":"ferric oxide","slug":"ferric-oxide","company":""},{"name":"phenylephrine","slug":"phenylephrine","company":"Ani Pharms"},{"name":"pramocaine","slug":"pramocaine","company":"Sebela Ireland Ltd"},{"name":"zinc acetate","slug":"zinc-acetate","company":"Armour Pharm"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"phenylmercuric nitrate","explanation":"Think of it like a strong disinfectant that helps kill bacteria and reduce swelling in the affected area. This can help relieve symptoms like itching, pain, and discomfort. By targeting the root cause of the problem, phenylmercuric nitrate can help promote healing and reduce the risk of infection.","oneSentence":"Phenylmercuric nitrate works by releasing mercury ions that have antimicrobial and anti-inflammatory properties.","technicalDetail":"Phenylmercuric nitrate exerts its effects through the release of mercury ions, which have antimicrobial and anti-inflammatory properties. The mercury ions bind to sulfhydryl groups on bacterial cell walls, disrupting cellular function and leading to cell death. Additionally, the mercury ions may also inhibit the production of pro-inflammatory mediators, contributing to its anti-inflammatory effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4688","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=phenylmercuric nitrate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:19:33.853561","biosimilars":[],"competitors":[{"drugName":"nitrofurazone","drugSlug":"nitrofurazone","fdaApproval":"1945-10-04","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"benzalkonium","drugSlug":"benzalkonium","fdaApproval":"","relationship":"same-class"},{"drugName":"triclosan","drugSlug":"triclosan","fdaApproval":"1997-07-11","relationship":"same-class"},{"drugName":"cetylpyridinium","drugSlug":"cetylpyridinium","fdaApproval":"","relationship":"same-class"},{"drugName":"aluminium chlorohydrate","drugSlug":"aluminium-chlorohydrate","fdaApproval":"","relationship":"same-class"},{"drugName":"povidone-iodine","drugSlug":"povidone-iodine","fdaApproval":"1985-11-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"clioquinol","drugSlug":"clioquinol","fdaApproval":"","relationship":"same-class"},{"drugName":"chlorhexidine","drugSlug":"chlorhexidine","fdaApproval":"1976-09-17","patentExpiry":"Oct 2, 2027","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"phenylmercuric nitrate","indications":{"approved":[{"name":"Hemorrhoids","source":"DrugCentral","snomedId":70153002,"regulator":"FDA"},{"name":"Proctitis","source":"DrugCentral","snomedId":3951002,"regulator":"FDA","usPrevalence":null,"globalPrevalence":2800000,"prevalenceMethod":"curated","prevalenceSource":"Orphanet (European Medicines Agency[INST])"},{"name":"Pruritus ani","source":"DrugCentral","snomedId":90446007,"regulator":"FDA"},{"name":"Rectal pain","source":"DrugCentral","snomedId":77880009,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"nitrofurazone","brandName":"nitrofurazone","genericName":"nitrofurazone","approvalYear":"1945","relationship":"same-class"},{"drugId":"benzalkonium","brandName":"benzalkonium","genericName":"benzalkonium","approvalYear":"","relationship":"same-class"},{"drugId":"triclosan","brandName":"triclosan","genericName":"triclosan","approvalYear":"1997","relationship":"same-class"},{"drugId":"cetylpyridinium","brandName":"cetylpyridinium","genericName":"cetylpyridinium","approvalYear":"","relationship":"same-class"},{"drugId":"aluminium-chlorohydrate","brandName":"aluminium chlorohydrate","genericName":"aluminium chlorohydrate","approvalYear":"","relationship":"same-class"},{"drugId":"povidone-iodine","brandName":"povidone-iodine","genericName":"povidone-iodine","approvalYear":"1985","relationship":"same-class"},{"drugId":"clioquinol","brandName":"clioquinol","genericName":"clioquinol","approvalYear":"","relationship":"same-class"},{"drugId":"chlorhexidine","brandName":"chlorhexidine","genericName":"chlorhexidine","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000146383","MMSL":"NOCODE","NDDF":"003123","UNII":"CG8692ZN14","VUID":"4018041","VANDF":"4018041","RXNORM":"89722","UMLSCUI":"C0301304","ChEMBL_ID":"CHEMBL3833360","KEGG_DRUG":"D05465","DRUGBANK_ID":"DB13388","PUBCHEM_CID":"9840857"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":56,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"D09AA04","allCodes":["D09AA04"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"phenylmercuric nitrate","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Phenylmercuric nitrate is a small molecule with antiseptic and antifungal effects, previously used as a topical solution for disinfecting wounds. It is still used in low concentrations as a preservative in eye drops for ophthalmic use.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}