{"id":"phenylephrine-bitartrate","rwe":[{"pmid":"20122809","year":"2010","title":"Investigating the degradation of the sympathomimetic drug phenylephrine by electrospray ionisation-mass spectrometry.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"16892519","year":"2006","title":"Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use; amendment of monograph for OTC nasal decongestant drug products. Final rule.","finding":"","journal":"Federal register","studyType":"Clinical Study"}],"_fda":{"id":"26d160c4-5477-17b2-e063-6394a90a6305","set_id":"440a00b1-7960-0cc4-e054-00144ff8d46c","openfda":{"nui":["N0000000160","N0000008836","M0001335","N0000175722","N0000175578","N0000008832"],"unii":["R16CO5Y76E","V1Q0O9OJ9Z","27O3Q5ML57"],"route":["ORAL"],"rxcui":["1536840"],"spl_id":["26d160c4-5477-17b2-e063-6394a90a6305"],"brand_name":["Top Value Effervescent Cold Relief"],"spl_set_id":["440a00b1-7960-0cc4-e054-00144ff8d46c"],"package_ndc":["50201-7682-2"],"product_ndc":["50201-7682"],"generic_name":["ASPIRIN, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE BITARTRATE"],"product_type":["HUMAN OTC DRUG"],"pharm_class_cs":["Anti-Inflammatory Agents, Non-Steroidal [CS]"],"pharm_class_pe":["Decreased Prostaglandin Production [PE]","Decreased Platelet Aggregation [PE]"],"substance_name":["ASPIRIN","CHLORPHENIRAMINE MALEATE","PHENYLEPHRINE BITARTRATE"],"pharm_class_epc":["Nonsteroidal Anti-inflammatory Drug [EPC]","Platelet Aggregation Inhibitor [EPC]"],"pharm_class_moa":["Cyclooxygenase Inhibitors [MoA]"],"manufacturer_name":["Tower Laboratories Ltd"],"application_number":["M012"],"is_original_packager":[true]},"purpose":["Purpose Pain reliever/fever reducer Antihistamine Nasal decongestant"],"version":"5","stop_use":["Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better ■ an allergic reaction occurs. Seek medical help right away. ■ pain or nasal congestion gets worse or lasts more than 7 days ■ fever gets worse or lasts more than 3 days ■ new symptoms occur ■ redness or swelling is present ■ ringing in the ears or a loss of hearing occurs ■ nervousness, dizziness or sleeplessness occurs"],"warnings":["Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock Stomach bleeding warning: This product contains a nonsteroidal anti-inflammatory drug (NSAID), which may cause severe stomach bleeding. The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly."],"questions":["Serious side effects associated with the use of this product can be reported to the following address: Tower Laboratories LTD P.O. Box 306 8 Industrial Park Road Centerbrook, CT 06409"],"ask_doctor":["Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have a history of stomach problems, such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ■ you are taking a diuretic ■ you are taking sedatives or tranquilizers You have ■ glaucoma ■ diabetes ■ thyroid disease ■ trouble urinating due to an enlarged prostate gland ■ a breathing problem such as emphysema or chronic bronchitis ■ been placed on a sodium-restricted diet"],"do_not_use":["Do not use ■ if you have ever had an allergic reaction to any other pain reliever/fever reducer ■ if you are allergic to aspirin ■ if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product."],"overdosage":["In case of overdose, get medical help or contact a Poison Control Center right away."],"when_using":["When using this product ■ do not take more than 8 tablets (adults and children 12 years and over) in a 24-hour period or as directed by doctor. ■ do not use more than directed ■ you may get drowsy ■ avoid alcoholic drinks ■ excitability may occur, especially in children ■ alcohol, sedatives and tranquilizers may increase drowsiness ■ be careful when driving a motor vehicle or operating machinery"],"effective_time":"20241113","active_ingredient":["Active ingredients Aspirin 325 mg (NSAID)* Chlorpheniramine maleate 2 mg Phenylephrine Bitartrate 7.8 mg *Nonsteroidal anti-inflammatory drug"],"inactive_ingredient":["Inactive Ingredients: acesulfame potassium, aspartame, citric acid, docusate sodium, flavors, mannitol, povidone, sodium benzoate, sodium bicarbonate"],"indications_and_usage":["Uses temporarily relieves these symptoms of the common cold ■ fever ■ sneezing ■ nasal congestion ■ sore throat ■ headache ■ minor aches and pains ■ runny nose ■ sinus congestion and pressure"],"ask_doctor_or_pharmacist":["Ask a doctor or pharmacist before use if you are ■ presently taking a prescription drug. ■ taking a prescription drug for anticoagulation (thinning the blood), diabetes, gout or arthritis"],"other_safety_information":["Other information each tablet contains: sodium 464 mg ■ phenylketonurics: contains phenylalanine 9 mg per tablet ■ store at room temperature (59°-86°F)"],"dosage_and_administration":["Directions ■ do not use more than directed (see overdose warning) ■ adults and children 12 years and over: take 2 tablets completely dissolved in 4 ounces of water every 4-6 hours ■ do not take more than 8 tablets in 24 hours ■ children under 12 years: ask a doctor"],"spl_product_data_elements":["Top Value Effervescent Cold Relief Aspirin, Chlorpheniramine Maleate, Phenylephrine Bitartrate ACESULFAME POTASSIUM SODIUM BENZOATE ASPIRIN ASPIRIN PHENYLEPHRINE BITARTRATE PHENYLEPHRINE DOCUSATE SODIUM ASPARTAME SODIUM BICARBONATE CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE ANHYDROUS CITRIC ACID MANNITOL POVIDONE K30"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery."],"keep_out_of_reach_of_children":["Keep out of reach of children."],"package_label_principal_display_panel":["Package label Principle display panel"]},"tags":[{"label":"alpha-1 Adrenergic Agonist","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Alpha-1B adrenergic receptor","category":"target"},{"label":"ADRA1B","category":"gene"},{"label":"ADRA2A","category":"gene"},{"label":"ADRA2B","category":"gene"},{"label":"C01CA06","category":"atc"},{"label":"Oral","category":"route"},{"label":"Capsule","category":"form"},{"label":"Active","category":"status"},{"label":"Allergic conjunctivitis","category":"indication"},{"label":"Allergic rhinitis","category":"indication"},{"label":"Common cold","category":"indication"},{"label":"Cough","category":"indication"},{"label":"Dilated pupil","category":"indication"},{"label":"Fever","category":"indication"},{"label":"Ani Pharms","category":"company"},{"label":"Approved 1950s","category":"decade"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-1 Receptor Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-Agonists","category":"pharmacology"},{"label":"Cardiotonic Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Mydriatics","category":"pharmacology"},{"label":"Nasal Decongestants","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"},{"label":"Vasoconstrictor Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"CEREBROVASCULAR ACCIDENT","source":"FDA FAERS","actionTaken":"10 reports"},{"date":"","signal":"CHOKING","source":"FDA FAERS","actionTaken":"10 reports"},{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"10 reports"},{"date":"","signal":"MALAISE","source":"FDA FAERS","actionTaken":"8 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"8 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"7 reports"},{"date":"","signal":"DRUG DEPENDENCE","source":"FDA FAERS","actionTaken":"6 reports"},{"date":"","signal":"FOREIGN BODY IN THROAT","source":"FDA FAERS","actionTaken":"6 reports"},{"date":"","signal":"ABDOMINAL DISCOMFORT","source":"FDA FAERS","actionTaken":"5 reports"},{"date":"","signal":"DIZZINESS","source":"FDA FAERS","actionTaken":"5 reports"}],"drugInteractions":[{"url":"/drug/ioflupane-i-123","drug":"Ioflupane I-123","action":"Monitor closely","effect":"May interact with Ioflupane I-123, Phenylephrine","source":"DrugCentral","drugSlug":"ioflupane-i-123"},{"url":"/drug/rasagiline","drug":"rasagiline","action":"Avoid combination","effect":"May interact with Phenylephrine, Rasagiline","source":"DrugCentral","drugSlug":"rasagiline"},{"url":"/drug/tranylcypromine","drug":"tranylcypromine","action":"Avoid combination","effect":"May interact with Phenylephrine, Tranylcypromine","source":"DrugCentral","drugSlug":"tranylcypromine"}],"commonSideEffects":[],"contraindications":["Achalasia of esophagus","Acidosis","Acute abdominal pain","Acute erosive gastritis","Acute exacerbation of asthma","Acute hepatitis","Acute nephropathy","Acute pancreatitis","Acute tuberculosis","Adrenal cortical hypofunction","Agoraphobia","Alcohol intoxication","Alcohol withdrawal delirium","Alcoholism","Anemia","Anemia due to enzyme deficiency","Angle-closure glaucoma","Anuria","Anxiety","Arterial aneurysm","Arterial thrombosis","Arteriosclerotic vascular disease","Asthenia","Atony of colon","Autonomic dysreflexia"],"specialPopulations":{"Pregnancy":"Use in Pregnancy: Pregnancy Category C. Animal reproduction studies have not been conducted with CPM/PE/DM Syrup. It is not known whether these products can cause fetal harm when administered to pregnant woman or affect reproduction capacity. Give to pregnant woman only if clearly needed.","Geriatric use":"Clinical studies of promethazine hydrochloride, phenylephrine hydrochloride and codeine phosphate syrup did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range","Paediatric use":"The combination of promethazine hydrochloride, phenylephrine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 2 years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and sometimes death, in pediatric patients."}},"trials":[],"aliases":[],"company":"ANI Pharmaceuticals","patents":[{"source":"FDA Orange Book via DrugCentral","expires":"2036-09-26","territory":"US","patentNumber":"11213480"},{"source":"FDA Orange Book via DrugCentral","expires":"2036-08-05","territory":"US","patentNumber":"11471400"},{"source":"FDA Orange Book via DrugCentral","expires":"2034-04-23","territory":"US","patentNumber":"9066856*PED"},{"source":"FDA Orange Book via DrugCentral","expires":"2034-04-23","territory":"US","patentNumber":"9486406*PED"},{"source":"FDA Orange Book via DrugCentral","expires":"2033-11-14","territory":"US","patentNumber":"8859623"},{"source":"FDA Orange Book via DrugCentral","expires":"2033-10-23","territory":"US","patentNumber":"9066856"},{"source":"FDA Orange Book via DrugCentral","expires":"2033-10-23","territory":"US","patentNumber":"9486406"},{"source":"FDA Orange Book via DrugCentral","expires":"2033-10-23","territory":"US","patentNumber":"9855246"},{"source":"FDA Orange Book via DrugCentral","expires":"2024-01-30","territory":"US","patentNumber":"8173707*PED"},{"source":"FDA Orange Book via DrugCentral","expires":"2024-01-30","territory":"US","patentNumber":"8586633*PED"},{"source":"FDA Orange Book via DrugCentral","expires":"2024-01-30","territory":"US","patentNumber":"9278101*PED"},{"source":"FDA Orange Book via DrugCentral","expires":"2024-01-30","territory":"US","patentNumber":"9399040*PED"},{"source":"FDA Orange Book via DrugCentral","expires":"2023-07-30","territory":"US","patentNumber":"8173707"},{"source":"FDA Orange Book via DrugCentral","expires":"2023-07-30","territory":"US","patentNumber":"8586633"},{"source":"FDA Orange Book via DrugCentral","expires":"2023-07-30","territory":"US","patentNumber":"9278101"},{"source":"FDA Orange Book via DrugCentral","expires":"2023-07-30","territory":"US","patentNumber":"9399040"}],"pricing":[{"market":"United States","source":"CMS National Average Drug Acquisition Cost (NADAC)","asOfDate":"2024-01-03","unitCost":"$0.0476/EA","priceType":"NADAC","sourceUrl":"https://data.medicaid.gov/dataset/4j6z-xnwq","annualCost":"$17","description":"PHENYLEPHRINE 10 MG TABLET","retrievedDate":"2026-04-07"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=PHENYLEPHRINE BITARTRATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:11:25.124634+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-20T01:11:25.124550+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:11:30.641373+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PHENYLEPHRINE BITARTRATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:11:31.142676+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:11:22.709141+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:11:22.709172+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:11:22.709178+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T01:11:32.612955+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Adrenergic receptor alpha-1 agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:11:32.201128+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2062264/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:11:31.866170+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M012","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T01:11:22.709181+00:00"}},"allNames":"phenergan vc w/ codeine","offLabel":[],"synonyms":["(-)-Phenylephrine","(-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol","(-)-m-Oxedrine","(-)-m-Synephrine","(R)-Phenylephrine","L-Phenylephedrine","mesatone","metaoxedrin","metaoxedrine","metasympatol","metasynephrine","mezaton","l-Phenylephrine","phenylephrine","phenylephrine hydrochloride","phenylephrine tannate","phenylephrine bitartrate","phenylephrine HCl"],"timeline":[{"date":"1952-01-21","type":"positive","source":"DrugCentral","milestone":"FDA approval (Ani Pharms)"}],"aiSummary":"Phenergan Vc W/ Codeine is a medication developed by ANI PHARMS, targeting the alpha-1B adrenergic receptor. It belongs to the alpha-1 Adrenergic Agonist class and is a small molecule modality. Approved by the FDA in 1952, it treats various conditions including allergic conjunctivitis, allergic rhinitis, and cough. The commercial status of Phenergan Vc W/ Codeine is owned by ANI PHARMS, and its key safety considerations include potential side effects such as drowsiness and dry mouth. As an alpha-1 adrenergic agonist, it works by stimulating the alpha-1B adrenergic receptor, leading to vasoconstriction and increased blood pressure.","brandName":"Phenergan Vc W/ Codeine","ecosystem":[{"indication":"Allergic conjunctivitis","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alcaftadine","slug":"alcaftadine","company":"Allergan"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null},{"indication":"Allergic rhinitis","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"},{"name":"astemizole","slug":"astemizole","company":""}],"globalPrevalence":null},{"indication":"Common cold","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"azatadine","slug":"azatadine","company":""}],"globalPrevalence":null},{"indication":"Cough","otherDrugs":[{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"benzocaine","slug":"benzocaine","company":""},{"name":"benzonatate","slug":"benzonatate","company":"Pfizer"},{"name":"bromazine","slug":"bromazine","company":"Forest Labs"}],"globalPrevalence":null},{"indication":"Dilated pupil","otherDrugs":[{"name":"cyclopentolate","slug":"cyclopentolate","company":"Alcon Labs Inc"},{"name":"hydroxyamfetamine","slug":"hydroxyamfetamine","company":"Pharmics"},{"name":"scopolamine","slug":"scopolamine","company":"Novartis"},{"name":"tropicamide","slug":"tropicamide","company":""}],"globalPrevalence":null},{"indication":"Fever","otherDrugs":[{"name":"choline magnesium trisalicylate","slug":"choline-magnesium-trisalicylate","company":""},{"name":"codeine","slug":"codeine","company":"Ani Pharms"},{"name":"dextromethorphan","slug":"dextromethorphan","company":"Ani Pharms"},{"name":"guaifenesin","slug":"guaifenesin","company":"Reckitt Benckiser"}],"globalPrevalence":2000000000},{"indication":"Headache disorder","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"citric acid","slug":"citric-acid","company":"Baxter Hlthcare"},{"name":"codeine","slug":"codeine","company":"Ani Pharms"}],"globalPrevalence":1400000000},{"indication":"Hemorrhoids","otherDrugs":[{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"ferric oxide","slug":"ferric-oxide","company":""},{"name":"hydrocortisone","slug":"hydrocortisone","company":"Merck"},{"name":"hydrocortisone acetate","slug":"hydrocortisone-acetate","company":"Merck"}],"globalPrevalence":null}],"mechanism":{"target":"Alpha-1B adrenergic receptor","novelty":"Follow-on","targets":[{"gene":"ADRA1B","source":"DrugCentral","target":"Alpha-1B adrenergic receptor","protein":"Alpha-1B adrenergic receptor"},{"gene":"ADRA2A","source":"DrugCentral","target":"Adrenergic receptor alpha-2","protein":"Alpha-2A adrenergic receptor"},{"gene":"ADRA2B","source":"DrugCentral","target":"Adrenergic receptor alpha-2","protein":"Alpha-2B adrenergic receptor"},{"gene":"ADRA2C","source":"DrugCentral","target":"Adrenergic receptor alpha-2","protein":"Alpha-2C adrenergic receptor"},{"gene":"ADRA1D","source":"DrugCentral","target":"Alpha-1D adrenergic receptor","protein":"Alpha-1D adrenergic receptor"},{"gene":"ADRA1A","source":"DrugCentral","target":"Alpha-1A adrenergic receptor","protein":"Alpha-1A adrenergic receptor"}],"moaClass":"Adrenergic alpha1-Agonists","modality":"Small Molecule","drugClass":"Nonsteroidal Anti-inflammatory Drug [EPC]","explanation":"","oneSentence":"","technicalDetail":"Phenergan Vc W/ Codeine acts as an agonist at the alpha-1B adrenergic receptor, a subtype of the alpha-1 adrenergic receptor family, which is a G protein-coupled receptor. Activation of this receptor leads to an increase in intracellular calcium levels, resulting in vasoconstriction and increased blood pressure."},"commercial":{"launchDate":"1952","_launchSource":"DrugCentral (FDA 1952-01-21, ANI PHARMS)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2146","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PHENYLEPHRINE%20BITARTRATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PHENYLEPHRINE 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available","relationship":"same-class"},{"drugName":"metaraminol","drugSlug":"metaraminol","fdaApproval":"1954-09-29","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methoxamine","drugSlug":"methoxamine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"mephentermine","drugSlug":"mephentermine","fdaApproval":"1951-12-29","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"midodrine","drugSlug":"midodrine","fdaApproval":"1996-09-06","genericCount":14,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"fenoldopam","drugSlug":"fenoldopam","fdaApproval":"1997-09-23","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"arbutamine","drugSlug":"arbutamine","fdaApproval":"1997-09-12","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"epinephrine","drugSlug":"epinephrine","fdaApproval":"1948-11-19","patentExpiry":"Oct 20, 2036","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"ephedrine","drugSlug":"ephedrine","fdaApproval":"","patentExpiry":"May 16, 2040","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"droxidopa","drugSlug":"droxidopa","fdaApproval":"2014-02-18","genericCount":16,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://data.medicaid.gov/dataset/4j6z-xnwq","name":"CMS National Average Drug Acquisition Cost (NADAC)","fields":["pricing"],"retrievedDate":"2026-04-07"}],"genericName":"phenylephrine bitartrate","indications":{"approved":[{"name":"Allergic 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