{"id":"phentolamine-opthalmic-solution-0-75","safety":{"commonSideEffects":[{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Blurred vision"}]},"_chembl":{"chemblId":"CHEMBL1200873","moleculeType":"Small molecule","molecularWeight":"377.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Phentolamine works by antagonizing alpha-1 and alpha-2 adrenergic receptors in ocular tissues. By blocking these receptors, it causes miosis (pupil constriction) and may enhance trabecular outflow of aqueous humor, thereby reducing intraocular pressure. This mechanism is relevant for conditions where elevated intraocular pressure contributes to vision loss.","oneSentence":"Phentolamine is an alpha-adrenergic receptor antagonist that blocks norepinephrine signaling in the eye to reduce pupil dilation and improve aqueous humor outflow.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:55:18.370Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Presbyopia (age-related loss of accommodation)"},{"name":"Intraocular pressure reduction in glaucoma or ocular hypertension (investigational)"}]},"trialDetails":[{"nctId":"NCT05646719","phase":"PHASE3","title":"Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia","status":"COMPLETED","sponsor":"Ocuphire Pharma, Inc.","startDate":"2022-12-22","conditions":"Presbyopia","enrollment":333}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nyxol"],"phase":"phase_3","status":"active","brandName":"Phentolamine Opthalmic Solution 0.75%","genericName":"Phentolamine Opthalmic Solution 0.75%","companyName":"Ocuphire Pharma, Inc.","companyId":"ocuphire-pharma-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Phentolamine is an alpha-adrenergic receptor antagonist that blocks norepinephrine signaling in the eye to reduce pupil dilation and improve aqueous humor outflow. Used for Presbyopia (age-related loss of accommodation), Intraocular pressure reduction in glaucoma or ocular hypertension (investigational).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}