{"id":"phenoxyethanol","rwe":[{"pmid":"41858939","year":"2026","title":"Green RP-HPLC method for the simultaneous determination of octenidine and phenoxyethanol in antiseptic formulations: integration of a lean six sigma approach.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41812953","year":"2026","title":"An efficient biphasic pretreatment for fractionation and conversion of eucalyptus wood for production of dissolving pulp, lactic acid, and lignin.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"41752629","year":"2026","title":"Laboratory and Field Soil Tunneling/Tubing by Subterranean Termites in Response to 2-Phenoxyethanol.","finding":"","journal":"Insects","studyType":"Clinical Study"},{"pmid":"41692689","year":"2026","title":"Allergic Risk of Moisturising Cosmetic Products: A Study on the Composition of 300 Products Commercialised in Tunisia.","finding":"","journal":"Contact dermatitis","studyType":"Clinical Study"},{"pmid":"41685624","year":"2026","title":"Preservative Kinetics and Influence of Surfactants on Gram-Negative Bacterial Membrane Partitioning.","finding":"","journal":"Langmuir : the ACS journal of surfaces and colloids","studyType":"Clinical Study"}],"tags":[{"label":"phenoxyethanol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Extracorporeal","category":"route"},{"label":"Topical","category":"route"},{"label":"Cutaneous","category":"route"},{"label":"Cloth","category":"form"},{"label":"Concentrate","category":"form"},{"label":"Active","category":"status"},{"label":"Antiseptic preparation","category":"indication"},{"label":"Anesthetics","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Infective Agents, Local","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Depressants","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=phenoxyethanol","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:45:25.739344+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:45:31.201222+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=phenoxyethanol","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:45:31.570895+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1229846/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:45:32.356325+00:00"}},"allNames":"phenoxethol","offLabel":[],"synonyms":["2-phenoxyethanol","(2-Hydroxyethoxy)benzene","ethylene glycol monophenyl ether","phenoxethol","phenoxyethyl alcohol","phenoxyethanol"],"timeline":[],"aiSummary":"Phenoxethol, also known as phenoxyethanol, is a small molecule antiseptic preparation. It is used to treat various skin and mucous membrane infections. The commercial status of phenoxethol is not explicitly stated, but it is likely available as a generic product. Key safety considerations include potential skin irritation and allergic reactions. As an antiseptic, phenoxethol works by disrupting the cell membranes of microorganisms, ultimately leading to their death.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Phenoxethol","ecosystem":[{"indication":"Antiseptic preparation","otherDrugs":[{"name":"boric acid","slug":"boric-acid","company":""},{"name":"chloroxylenol","slug":"chloroxylenol","company":""},{"name":"ethanol","slug":"ethanol","company":"B Braun"},{"name":"hydrogen peroxide","slug":"hydrogen-peroxide","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"phenoxyethanol","explanation":"","oneSentence":"","technicalDetail":"Phenoxyethol exerts its antimicrobial effects by interacting with the cell membrane of microorganisms, altering its permeability and ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3442","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=phenoxyethanol","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=phenoxyethanol","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:18:42.825077","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:45:33.917128+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"phenoxyethanol","indications":{"approved":[{"name":"Antiseptic preparation","source":"DrugCentral","snomedId":261276004,"regulator":"FDA","eligibility":"Adults and children, for use when soap and water are not available"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07500844","phase":"NA","title":"Decontamination Methods in the Treatment of Peri-implantitis","status":"COMPLETED","sponsor":"Research Centre for Medical Genetics, Russian Federation","startDate":"2023-02-01","conditions":["Peri-implantitis"],"enrollment":64,"completionDate":"2025-12-11"},{"nctId":"NCT05500482","phase":"PHASE4","title":"Vellore Typhoid Vaccine Impact Trial","status":"COMPLETED","sponsor":"Christian Medical College, Vellore, India","startDate":"2023-05-01","conditions":["Typhoid Fever"],"enrollment":72400,"completionDate":"2026-02-28"},{"nctId":"NCT06750653","phase":"PHASE4","title":"Skin Barrier Function and Inflammation in Aging: The BIA Study","status":"RECRUITING","sponsor":"University of California, San Francisco","startDate":"2025-02-06","conditions":["Inflammation","Skin Inflammation","Aging"],"enrollment":32,"completionDate":"2026-04-15"},{"nctId":"NCT07372677","phase":"NA","title":"Pocket-X Gel Non-surgical Periodontal Therapy","status":"RECRUITING","sponsor":"Universita di Verona","startDate":"2025-06-03","conditions":["Diabete Type 2"],"enrollment":70,"completionDate":"2030-01"},{"nctId":"NCT06817421","phase":"PHASE4","title":"Opportunistic Pneumococcal Immunisation Trial in MALnutrition","status":"NOT_YET_RECRUITING","sponsor":"Nick Fancourt","startDate":"2026-01","conditions":["Severe Acute Malnutrition in Childhood","Pneumococcal Disease","Pneumococcal Vaccines","Pneumococcal Infection","Pneumonia in Children"],"enrollment":214,"completionDate":"2029-02"},{"nctId":"NCT06473519","phase":"PHASE3","title":"A Study to Assess Safety, Tolerability and Immunogenicity of RSVpreF From Multidose Vials in Healthy Female Adults.","status":"COMPLETED","sponsor":"Pfizer","startDate":"2024-06-24","conditions":["Respiratory Syncytial Virus (RSV)"],"enrollment":453,"completionDate":"2024-09-20"},{"nctId":"NCT06178367","phase":"PHASE3","title":"Effectiveness and Safety of Topical Hyaluronic Acid of Different Molecular Weights in Xerotic Skin Treatment","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2023-08-26","conditions":["Xerosis Cutis"],"enrollment":36,"completionDate":"2023-09-30"},{"nctId":"NCT05386810","phase":"PHASE3","title":"Safety of Sabin Inactivated Poliovirus Vaccine in Adults, Children and Infants and Lot Consistency Immunogenicity, and Safety of the msIPV in 2 Months Old Infants","status":"COMPLETED","sponsor":"Sinovac Biotech Co., Ltd","startDate":"2020-11-05","conditions":["Poliomyelitis"],"enrollment":1572,"completionDate":"2023-07-20"},{"nctId":"NCT06122467","phase":"NA","title":"A Single Group Study to Evaluate the Efficacy of a Cosmetic Product Line on Acne Symptoms","status":"COMPLETED","sponsor":"Menning Labs","startDate":"2023-10-02","conditions":["Acne"],"enrollment":36,"completionDate":"2023-12-31"},{"nctId":"NCT06148662","phase":"PHASE4","title":"The Effect of Oral Sprays on Salivary pH","status":"COMPLETED","sponsor":"I.M. 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