{"id":"phenolphthalein","rwe":[],"_fda":{"id":"0e771c1f-5981-e177-e063-6394a90a0b89","set_id":"ba5e7801-667b-ab7c-e053-2995a90a788c","openfda":{"upc":["0818960012977"],"unii":["1364PS73AF","2P3VWU3H10","SIR7XX2F1K","J64922108F","3417WMA06D","CL2T97X0V0","0F5N573A2Y","1C89KKC04E","2P299V784P","4IL61GN3YI","SK47B8698T","Y4S76JWI15","339NCG44TV","6QK969R2IF","27YLU75U4W","A49OS0F91S","YFH4WC535J","W00D22B592","O40UQP6WCF","290YE8AR51","C5H0QJ6V7F","00J9J9XKDE"],"route":["SUBLINGUAL"],"spl_id":["0e771c1f-5981-e177-e063-6394a90a0b89"],"brand_name":["N02 PETROCHEM"],"spl_set_id":["ba5e7801-667b-ab7c-e053-2995a90a788c"],"package_ndc":["63479-1402-1"],"product_ndc":["63479-1402"],"generic_name":["ACETONE, ANILINUM, BENZINUM, BENZOPYRENE, CARBO VEGETABILIS, CARBOLICUM ACIDUM, CARBON TETRACHLORIDE, ETHER, MAGNESIA SULPHURICA, METHYL ALCOHOL, PETROLEUM, PHENOLPHTHALEIN, PHOSPHORUS, PICRICUM ACIDUM, PINE TAR, PLUMBOUS CHLORIDE, PLUMBUM METALLICUM, SULPHONALUM, SULPHURICUM ACIDUM, TEREBINTHINA, TRICHLOROETHYLENE, VANADIUM METALLICUM"],"product_type":["HUMAN OTC DRUG"],"substance_name":["ACETONE","ACTIVATED CHARCOAL","ANILINE","BENZENE","BENZO(A)PYRENE","CARBON TETRACHLORIDE","ETHER","KEROSENE","LEAD","LEAD CHLORIDE","MAGNESIUM SULFATE HEPTAHYDRATE","METHYL ALCOHOL","PHENOL","PHENOLPHTHALEIN","PHOSPHORUS","PICRIC ACID","PINE TAR","SULFONMETHANE","SULFURIC ACID","TRICHLOROETHYLENE","TURPENTINE OIL","VANADIUM"],"manufacturer_name":["Apex Energetics Inc."],"is_original_packager":[true]},"purpose":["Uses: For temporary relief of minor: headache* rash* muscle aches* itching* dizziness* confusion* diarrhea* *Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated."],"version":"2","stop_use":["Stop use and ask a doctor if headache, rash, muscle aches, itching, dizziness, confusion, diarrhea, or other symptoms do not improve within 7 days or are accompanied by fever."],"warnings":["Warnings: If pregnant or breastfeeding , ask a health professional before use. Do not use if clear seal over the cap is broken or missing. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Stop use and ask a doctor if headache, rash, muscle aches, itching, dizziness, confusion, diarrhea, or other symptoms do not improve within 7 days or are accompanied by fever."],"questions":["Distributed by Apex Energetics. Questions? 16592 Hale Ave., Irvine, CA 92606, USA"],"effective_time":"20240108","active_ingredient":["Active Ingredients Acetone 6X 9X 12X 15X Anilinum 6X 9X 12X 15X 30X Benzinum 6X 9X 12X 15X Benzopyrene 9X 12X 15X 30X Carbo Vegetabilis 4X 6X 9X 12X Carbolicum Acidum 6X 9X 12X 15X 30X Carbon Tetrachloride 6X 9X 12X 15X Ether 6X 9X 12X Magnesia Sulphurica 8X 10X 12X 15X Methyl Alcohol 6X 9X 12X Petroleum 6X 8X 10X 12X 15X 30X Phenolphthalein 6X 8X 10X 12X 15X Phosphorus 9X 12X 15X 30X Picricum Acidum 6X 8X 10X 12X 15X Pix Liquida 4X 6X 8X 10X 12X Plumbous Chloride 9X 10X 11X 12X 15X Plumbum Metallicum 9X 12X 15X Sulphonalum 6X 9X 12X 15X Sulphuricum Acidum 6X 9X 12X 15X Terebinthina 6X 9X 12X Trichloroethylene 6X 9X 12X 15X 30X Vanadium Metallicum 9X 12X 15X"],"inactive_ingredient":["alcohol (20% by volume), distilled water"],"indications_and_usage":["Uses: Uses: For temporary relief of minor: headache* rash* muscle aches* itching* dizziness* confusion* diarrhea* *Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated."],"active_ingredient_table":["
Active Ingredients
Acetone6X 9X 12X 15X
Anilinum6X 9X 12X 15X 30X
Benzinum6X 9X 12X 15X
Benzopyrene9X 12X 15X 30X
Carbo Vegetabilis4X 6X 9X 12X
Carbolicum Acidum6X 9X 12X 15X 30X
Carbon Tetrachloride6X 9X 12X 15X
Ether6X 9X 12X
Magnesia Sulphurica8X 10X 12X 15X
Methyl Alcohol6X 9X 12X
Petroleum6X 8X 10X 12X 15X 30X
Phenolphthalein6X 8X 10X 12X 15X
Phosphorus9X 12X 15X 30X
Picricum Acidum6X 8X 10X 12X 15X
Pix Liquida4X 6X 8X 10X 12X
Plumbous Chloride9X 10X 11X 12X 15X
Plumbum Metallicum9X 12X 15X
Sulphonalum6X 9X 12X 15X
Sulphuricum Acidum6X 9X 12X 15X
Terebinthina6X 9X 12X
Trichloroethylene6X 9X 12X 15X 30X
Vanadium Metallicum9X 12X 15X
"],"other_safety_information":["Do not use if clear seal over the cap is broken or missing."],"dosage_and_administration":["Directions: Adults & children ages 12 years and over: Take 10 drops under the tongue 3 times a day, or as directed by your healthcare professional. Consult a physician for use in children under 12 years of age."],"spl_product_data_elements":["N02 PETROCHEM ACETONE, ANILINUM, BENZINUM, BENZOPYRENE, CARBO VEGETABILIS, CARBOLICUM ACIDUM, CARBON TETRACHLORIDE, ETHER, MAGNESIA SULPHURICA, METHYL ALCOHOL, PETROLEUM, PHENOLPHTHALEIN, PHOSPHORUS, PICRICUM ACIDUM, PINE TAR, PLUMBOUS CHLORIDE, PLUMBUM METALLICUM, SULPHONALUM, SULPHURICUM ACIDUM, TEREBINTHINA, TRICHLOROETHYLENE, VANADIUM METALLICUM SULFURIC ACID SULFURIC ACID WATER ACETONE ACETONE PICRIC ACID PICRIC ACID PINE TAR PINE TAR SULFONMETHANE SULFONMETHANE VANADIUM VANADIUM ALCOHOL ACTIVATED CHARCOAL ACTIVATED CHARCOAL ANILINE ANILINE BENZENE BENZENE PHENOL PHENOL METHYL ALCOHOL METHYL ALCOHOL KEROSENE KEROSENE PHENOLPHTHALEIN PHENOLPHTHALEIN TURPENTINE OIL TURPENTINE OIL BENZO(A)PYRENE BENZO(A)PYRENE CARBON TETRACHLORIDE CARBON TETRACHLORIDE TRICHLOROETHYLENE TRICHLOROETHYLENE ETHER ETHER MAGNESIUM SULFATE HEPTAHYDRATE MAGNESIUM CATION PHOSPHORUS PHOSPHORUS LEAD CHLORIDE LEAD LEAD LEAD"],"pregnancy_or_breast_feeding":["If pregnant or breastfeeding , ask a health professional before use."],"keep_out_of_reach_of_children":["Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["FUTUREPLEX® N02 ANTITOX® PETROCHEM™ Homeopathic Formula Headache* Rash* Muscle Aches* 1 fl oz (30 mL) Alcohol 20% by Volume N0221-0310"]},"tags":[{"label":"phenolphthalein","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Thymidylate synthase","category":"target"},{"label":"TYMS","category":"gene"},{"label":"A06AB04","category":"atc"},{"label":"Active","category":"status"},{"label":"Indicators and Reagents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"contraindications":["Appendicitis","Gastrointestinal obstruction","Incontinence of feces"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=PHENOLPHTHALEIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T05:51:44.976027+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T05:52:17.054304+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T05:51:50.621685+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PHENOLPHTHALEIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T05:51:50.956350+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:51:43.844069+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:52:10.178930+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T05:51:43.844094+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL63857/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T05:51:51.655667+00:00"}},"allNames":"phthalin","offLabel":[],"synonyms":["phenolphthalein","euchessina","phthalimetten","phthalin"],"timeline":[],"aiSummary":"Phenolphthalein, marketed as Phthalin, is a drug primarily indicated for headache, operating through the inhibition of thymidylate synthase, an enzyme crucial for DNA synthesis. Its key competitive advantage lies in its unique mechanism of action, distinguishing it from same-class competitors such as oxyphenisatine, bisacodyl, castor oil, and sodium picosulfate. The primary risk to Phenolphthalein is the expiration of its key composition patent in 2028, which could lead to increased competition from generics.","approvals":[],"brandName":"Phthalin","ecosystem":[],"mechanism":{"target":"Thymidylate synthase, Thymidylate synthase","targets":[{"gene":"TYMS","source":"DrugCentral","target":"Thymidylate synthase","protein":"Thymidylate synthase"}],"modality":"Small Molecule","drugClass":"phenolphthalein","explanation":"","oneSentence":"","technicalDetail":"Phthalin acts as a competitive inhibitor of thymidylate synthase, binding to the enzyme's active site and preventing the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), a crucial step in DNA 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