{"id":"pheniprazine","rwe":[],"tags":[{"label":"pheniprazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Amine oxidase [flavin-containing] A","category":"target"},{"label":"MAOA","category":"gene"},{"label":"MAOB","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"phenizine","offLabel":[],"synonyms":["beta-phenylisopropylhydrazine","pheniprazine","1-phenyl-2-hydrazinopropane","phenizine","pheniprazine hydrochloride","pheniprazine HCl"],"timeline":[],"approvals":[],"brandName":"Phenizine","ecosystem":[],"mechanism":{"target":"Amine oxidase [flavin-containing] A, Amine oxidase [flavin-containing] B","targets":[{"gene":"MAOA","source":"DrugCentral","target":"Amine oxidase [flavin-containing] A","protein":"Amine oxidase [flavin-containing] A"},{"gene":"MAOB","source":"DrugCentral","target":"Amine oxidase [flavin-containing] B","protein":"Amine oxidase [flavin-containing] B"}],"modality":"Small Molecule","drugClass":"pheniprazine","explanation":"Think of it like a traffic cop in the brain. The enzyme amine oxidase [flavin-containing] A is like a traffic cop that helps break down certain chemicals, or neurotransmitters, that help our brain cells communicate. By blocking this traffic cop, pheniprazine can help increase the levels of these neurotransmitters, which can help improve mood and other brain functions.","oneSentence":"Pheniprazine works by inhibiting the enzyme amine oxidase [flavin-containing] A, which breaks down certain neurotransmitters in the brain.","technicalDetail":"Pheniprazine acts as a competitive inhibitor of amine oxidase [flavin-containing] A, which is a type of enzyme that catalyzes the oxidative deamination of various biogenic amines, including dopamine, serotonin, and norepinephrine."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2131","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PHENIPRAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:18:56.509825","biosimilars":[],"competitors":[{"drugName":"cyclizine","drugSlug":"cyclizine","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"donepezil","drugSlug":"donepezil","fdaApproval":"1996-11-25","patentExpiry":"Sep 23, 2037","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"isocarboxazid","drugSlug":"isocarboxazid","fdaApproval":"1959-07-01","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"istradefylline","drugSlug":"istradefylline","fdaApproval":"2019-08-27","patentExpiry":"Sep 5, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"linezolid","drugSlug":"linezolid","fdaApproval":"2000-04-18","genericCount":24,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"menadione","drugSlug":"menadione","fdaApproval":"","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"methylthioninium chloride","drugSlug":"methylthioninium-chloride","fdaApproval":"","relationship":"same-target"},{"drugName":"pargyline","drugSlug":"pargyline","fdaApproval":"1961-01-01","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"phenelzine","drugSlug":"phenelzine","fdaApproval":"1961-06-09","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"pioglitazone","drugSlug":"pioglitazone","fdaApproval":"1999-07-15","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"pheniprazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cyclizine","brandName":"cyclizine","genericName":"cyclizine","approvalYear":"","relationship":"same-target"},{"drugId":"donepezil","brandName":"donepezil","genericName":"donepezil","approvalYear":"1996","relationship":"same-target"},{"drugId":"isocarboxazid","brandName":"isocarboxazid","genericName":"isocarboxazid","approvalYear":"1959","relationship":"same-target"},{"drugId":"istradefylline","brandName":"istradefylline","genericName":"istradefylline","approvalYear":"2019","relationship":"same-target"},{"drugId":"linezolid","brandName":"linezolid","genericName":"linezolid","approvalYear":"2000","relationship":"same-target"},{"drugId":"menadione","brandName":"menadione","genericName":"menadione","approvalYear":"","relationship":"same-target"},{"drugId":"methylthioninium-chloride","brandName":"methylthioninium chloride","genericName":"methylthioninium chloride","approvalYear":"","relationship":"same-target"},{"drugId":"pargyline","brandName":"pargyline","genericName":"pargyline","approvalYear":"1961","relationship":"same-target"},{"drugId":"phenelzine","brandName":"phenelzine","genericName":"phenelzine","approvalYear":"1961","relationship":"same-target"},{"drugId":"pioglitazone","brandName":"pioglitazone","genericName":"pioglitazone","approvalYear":"1999","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"37VKD7067M","CHEBI":"CHEBI:134773","INN_ID":"981","UMLSCUI":"C0031407","ChEMBL_ID":"CHEMBL22498","DRUGBANK_ID":"DB09250","PUBCHEM_CID":"5929","SECONDARY_CAS_RN":"66-05-7","MESH_SUPPLEMENTAL_RECORD_UI":"C084776"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":144,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pheniprazine is a small molecule with the synonyms FENIPRAZINA, PHENIPRAZINE, PHENIPRAZINE, and PHENIPRAZINE DL-FORM.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}