{"id":"phenadoxone","rwe":[{"pmid":"9142400","year":"1997","title":"The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956.","finding":"","journal":"British journal of pharmacology","studyType":"Clinical Study"},{"pmid":"6138405","year":"1983","title":"Methadone radioimmunoassay: two simple methods.","finding":"","journal":"The Journal of pharmacy and pharmacology","studyType":"Clinical Study"},{"pmid":"13651575","year":"1959","title":"Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion.","finding":"","journal":"British journal of pharmacology and chemotherapy","studyType":"Clinical Study"},{"pmid":"13413163","year":"1957","title":"The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.","finding":"","journal":"British journal of pharmacology and chemotherapy","studyType":"Clinical Study"},{"pmid":"14898462","year":"1951","title":"The determination of phenadoxone.","finding":"","journal":"The Journal of pharmacy and pharmacology","studyType":"Clinical Study"}],"tags":[{"label":"phenadoxone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"heptazone","offLabel":[],"synonyms":["phenadoxone","heptazone","morphodone","phenodoxone","phenadoxone hydrochloride","phenadoxone HCl"],"timeline":[],"approvals":[],"brandName":"Heptazone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"phenadoxone","explanation":"Imagine your body has a lockbox that controls pain and feelings of well-being. Heptazone is thought to fit into this lockbox and adjust the way it works, helping to reduce pain and discomfort. However, the exact details of how it fits into the lockbox and what it does once inside are not yet fully understood.","oneSentence":"Heptazone is believed to work by modulating opioid receptors.","technicalDetail":"Phenadoxone is a phenanthrene derivative that is thought to act as a partial agonist at the mu-opioid receptor, potentially leading to analgesic and sedative effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3435","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PHENADOXONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:17:51.287725","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:26.140154+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"phenadoxone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"375W3TA42N","CHEBI":"CHEBI:135484","INN_ID":"4168","UMLSCUI":"C1882360","ChEMBL_ID":"CHEMBL2104551","PUBCHEM_CID":"10089","SECONDARY_CAS_RN":"545-91-5"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[{"date":"1997 Feb","pmid":"9142400","title":"The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. 1956.","journal":"British journal of pharmacology"},{"date":"1983 Sep","pmid":"6138405","title":"Methadone radioimmunoassay: two simple methods.","journal":"The Journal of pharmacy and pharmacology"},{"date":"1959 Mar","pmid":"13651575","title":"Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion.","journal":"British journal of pharmacology and chemotherapy"},{"date":"1957 Mar","pmid":"13413163","title":"The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum.","journal":"British journal of pharmacology and chemotherapy"},{"date":"1951 Nov","pmid":"14898462","title":"The determination of phenadoxone.","journal":"The Journal of pharmacy and pharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Heptazone is a small molecule with synonyms including CB-11 FREE BASE, FENADOXONA, HEPTAZONE, IDS-NP-005, MORPHODONE, and PHENADOXONE. Its exact mechanism and clinical uses are not specified in the provided information.","enrichmentLevel":5,"visitCount":1,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:51:26.140154+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}