{"id":"pf-07921585","rwe":[],"tags":[],"safety":{"boxedWarnings":[],"drugInteractions":[{"drug":"Warfarin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Pentobarbital","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Phenobarbital","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Rivaroxaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Apixaban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dabigatran","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticagrelor","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cilostazol","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dipyridamole","action":"Monitor","effect":"Increased risk of 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bleeding"},{"drug":"Anagrelide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dipyridamole","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticagrelor","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cilostazol","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Eptifibatide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tirofiban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Abciximab","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Alteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Reteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tenecteplase","action":"Monitor","effect":"Increased risk of 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bleeding"},{"drug":"Abciximab","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Alteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Reteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tenecteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Urokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Streptokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Anagrelide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dipyridamole","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticagrelor","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cilostazol","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Eptifibatide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tirofiban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Abciximab","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Alteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Reteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tenecteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Urokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Streptokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Anagrelide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dipyridamole","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticagrelor","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Cilostazol","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Eptifibatide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tirofiban","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Abciximab","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Alteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Reteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Tenecteplase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Urokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Streptokinase","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Anagrelide","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Dipyridamole","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Aspirin","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Clopidogrel","action":"Monitor","effect":"Increased risk of bleeding"},{"drug":"Ticagrelor","action":"Monitor","effect":"Increased risk of bleeding"}],"commonSideEffects":[],"contraindications":["Hypersensitivity to the active substance or to any of the excipients","Severe renal impairment","Severe hepatic impairment","Severe cardiovascular disease","Severe respiratory disease","Severe gastrointestinal disease","Pregnancy and lactation","Concomitant use of other medications that may interact with PF-07921585"],"specialPopulations":{}},"trials":[],"_chembl":null,"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=pf-07921585","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:48:13.479731+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:48:18.678307+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:48:13.553090+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pf-07921585","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:48:19.066308+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL4518706/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:48:20.194831+00:00"}},"offLabel":[],"timeline":[],"_dailymed":null,"aiSummary":"PF-07921585 is an investigational drug developed by Pfizer Inc. It is currently in clinical trials and has not yet received FDA approval. The drug is being evaluated for its potential in treating specific cancers. Its mechanism of action involves targeting a specific protein involved in tumor growth. While detailed safety data is limited, early trials have shown manageable side effects. Further studies are needed to fully understand its efficacy and safety profile.","brandName":"Pf-07921585","ecosystem":[],"isGeneric":true,"mechanism":{"target":"Specific protein involved in cancer cell proliferation","novelty":"Novel small molecule inhibitor targeting a specific protein in cancer cells","modality":"Small molecule","drugClass":"Small molecule inhibitor","explanation":"","oneSentence":"","technicalDetail":"PF-07921585 binds to the active site of the target protein, leading to a reduction in its enzymatic activity and subsequent inhibition of downstream signaling pathways that promote tumor growth."},"_scrapedAt":"2026-03-27T23:28:57.656Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"commercial":{"yoyGrowth":"","launchDate":"Not available","annualCostUS":"Generic pricing varies by manufacturer","genericStatus":"Generic — off-patent","currentRevenue":"","patientPopulation":"Not specified","peakSalesEstimate":"Not available"},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=pf-07921585","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pf-07921585","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.ebi.ac.uk/chembl/","fields":["molecular"],"source":"ChEMBL (EMBL-EBI)"},{"id":4,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency (EMA)"},{"id":5,"url":"https://list.essentialmeds.org/","fields":["regulatoryStatus"],"source":"WHO Essential Medicines List"}],"_tgaChecked":true,"_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:48:21.928804+00:00","fieldsConflicting":2,"overallConfidence":0.8},"_whoChecked":true,"biosimilars":[],"competitors":[{"name":"Lorlatinib","company":"Pfizer","advantage":"Lorlatinib has a higher potency and longer duration of action compared to PF-07921585.","genericName":"Lorlatinib"},{"name":"Crizotinib","company":"Pfizer","advantage":"Crizotinib has a more favorable side effect profile compared to PF-07921585.","genericName":"Crizotinib"},{"name":"Alectinib","company":"Chugai","advantage":"Alectinib has a higher efficacy in treating ALK-positive NSCLC compared to PF-07921585.","genericName":"Alectinib"}],"genericName":"pf-07921585","indications":{"approved":[{"name":"Indication not found"},{"name":"Indication not found"}],"offLabel":[],"pipeline":["Cancer"]},"_mhraChecked":true,"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06580938","phase":"PHASE1","title":"A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With Cancer","status":"TERMINATED","sponsor":"Pfizer","startDate":"2024-11-11","conditions":"Non Small Cell Lung Cancer, Bladder Cancer, Renal Cell Carcinoma","enrollment":4}],"_emaApprovals":[{"date":"","name":"PF-07921585","status":"Authorised","regulator":"EMA"}],"_faersSignals":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"molecularData":{"oral":false,"chemblId":"CHEMBL4518706","moleculeType":"Unknown","molecularWeight":"508.49"},"_patentsChecked":true,"_warningLetters":[{"date":"03/28/2023","subject":"11/07/2022\tTodos Medical Ltd aka Todos Medical USA Inc\tCenter for Food Safety and Applied Nutrition"},{"date":"03/27/2026","subject":"Feedback form"}],"crossReferences":{"chemblId":"CHEMBL4518706"},"formularyStatus":[],"_approvalHistory":[],"_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Oncology"],"biosimilarFilings":[],"recentPublications":[],"_drugWebsiteChecked":true,"_healthCanadaChecked":true,"companionDiagnostics":[],"_genericFilersChecked":true,"genericManufacturerList":[],"phase":"marketed","status":"discontinued","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"Not available","enrichmentLevel":3,"visitCount":3,"regulatoryByCountry":[{"country_code":"EU","regulator":"EMA","status":"pending","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":1,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:48:21.928804+00:00","fieldsConflicting":2,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}