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on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions.","Co-administration with potent inducers of CYP3A.","The concomitant use of PAXLOVID and certain other drugs may result in potentially significant drug interactions.","Hypersensitivity Reactions: Anaphylaxis, serious skin reactions (including toxic epidermal necrolysis and Stevens-Johnson syndrome).","Severe hepatic impairment (Child-Pugh Class C).","Co-administration with colchicine due to potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment.","Co-administration with atazanavir, darunavir, tipranavir due to potential loss of virologic response and possible resistance.","Co-administration with eplerenone due to potential for hyperkalemia.","Co-administration with St. John's Wort (hypericum perforatum) due to potential loss of virologic response and possible resistance."],"specialPopulations":{"Pregnancy":"The NIH Panel recommends against the use of Lagevrio in pregnant patients unless there are no other options and COVID-19 therapy is clearly indicated.","Geriatric use":"No specific information is provided.","Paediatric use":"Epclusa is indicated for the treatment of adults and pediatric patients ≥3 years with chronic HCV GT-1, -2, -3, -4, -5 or -6 infection.","Renal impairment":"No specific information is provided.","Hepatic impairment":"Other supporting clinical pharmacology studies in special populations (e.g., subjects with hepatic and renal impairment) are ongoing."}},"trials":[],"aliases":[],"company":"Pfizer","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=pf-07817883","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:31:55.877287+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Pf-07817883","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-19T23:32:03.846355+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:32:01.563485+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines 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It is designed to improve upon the limitations of nirmatrelvir, the active antiviral component of Paxlovid. The drug is currently in the marketed phase and has generated $21.2B in revenue. It is being developed for the treatment of COVID-19. PF-07817883 is a small molecule drug. Its mechanism of action involves inhibiting the SARS-CoV-2 main protease. The drug has shown promise in clinical trials, with 9 trials conducted and 4 publications. It is a best-in-class drug in its class.","brandName":"Pf-07817883","ecosystem":[],"isGeneric":true,"mechanism":{"target":"SARS-CoV-2 main protease","novelty":"Best-in-class","modality":"Small molecule","drugClass":"Protease inhibitor","explanation":"","oneSentence":"","technicalDetail":"Ibuzatrelvir works by binding to the SARS-CoV-2 main protease enzyme, preventing it from cleaving the viral polyprotein. This inhibition of the enzyme prevents the virus from replicating, thereby reducing the severity of COVID-19 symptoms. The drug's mechanism of action is similar to that of nirmatrelvir, but with some key differences that make it more effective."},"_companyIR":{"url":"https://www.pfizer.com/investors","revenueRefs":[],"pipelineRefs":[]},"_wikipedia":{"title":"Ibuzatrelvir","extract":"Ibuzatrelvir is an investigational antiviral drug developed by Pfizer for the treatment of COVID-19. It is a second-generation oral SARS-CoV-2 main protease (Mpro) inhibitor designed to improve upon the limitations of nirmatrelvir, the active antiviral component of Paxlovid, which is currently the only oral antiviral approved by the FDA for COVID-19 treatment.","wiki_development":"== Development ==\n=== Background ===\nIbuzatrelvir's design is derived from the structural framework of nirmatrelvir and exhibits extensive antiviral activity against coronaviruses in vitro, demonstrating efficacy in a mouse-adapted SARS-CoV-2 model following oral administration. Pfizer announced ibuzatrelvir as a second-generation SARS-CoV-2 M<sup>pro</sup> drug candidate, which has received fast-track status and has successfully completed Phase 2 clinical trials. It is more metabolically stable and has fewer potential drug-drug interactions. Additionally, participants in ibuzatrelvir's Phase 2 clinical trial did not report \"Paxlovid mouth,\" the unpleasant metallic taste side effect commonly associated with Paxlovid treatment."},"commercial":{"annualCostUS":"$80,000/yr","genericStatus":"Generic — off-patent","currentRevenue":"$21.2B","patientPopulation":"Generic — multiple manufacturers","peakSalesEstimate":"$21.2B"},"references":[{"id":1,"url":"https://clinicaltrials.gov/search?intr=pf-07817883","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pf-07817883","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.ebi.ac.uk/chembl/","fields":["molecular"],"source":"ChEMBL (EMBL-EBI)"},{"id":4,"url":"https://en.wikipedia.org/wiki/pf-07817883","fields":["history","overview"],"source":"Wikipedia"},{"id":5,"url":"https://www.ema.europa.eu/","fields":["regulatoryStatus"],"source":"European Medicines Agency 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PF-07817883.","status":"COMPLETED","sponsor":"Pfizer","startDate":"2024-09-10","conditions":"COVID-19","enrollment":16},{"nctId":"NCT06646042","phase":"PHASE1","title":"A Study to Learn If the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine Ibuzatrelvir in Healthy Adults","status":"COMPLETED","sponsor":"Pfizer","startDate":"2024-10-28","conditions":"Healthy","enrollment":12},{"nctId":"NCT06122194","phase":"PHASE1","title":"A Study to Learn PF-07817883 Blood Levels After Administration of Tablets of Study Drug to Healthy Adult Volunteers","status":"COMPLETED","sponsor":"Pfizer","startDate":"2023-11-23","conditions":"Healthy","enrollment":12},{"nctId":"NCT05580003","phase":"PHASE1","title":"A Study to Learn Safety and Blood Levels of PF-07817883 in Healthy People","status":"COMPLETED","sponsor":"Pfizer","startDate":"2022-10-17","conditions":"Healthy","enrollment":94},{"nctId":"NCT05799495","phase":"PHASE2","title":"A Study to Understand the 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PF-07817883.","status":"COMPLETED","sponsor":"Pfizer","startDate":"2023-06-15","conditions":"COVID-19","enrollment":21}],"_emaApprovals":[{"date":"","name":"PF-07817883","status":"Authorised","regulator":"EMA"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"molecularData":{"oral":false,"chemblId":"CHEMBL5591580","moleculeType":"Small molecule","molecularWeight":"489.50"},"_patentsChecked":true,"_warningLetters":[{"date":"03/28/2023","subject":"11/07/2022\tTodos Medical Ltd aka Todos Medical USA Inc\tCenter for Food Safety and Applied Nutrition"},{"date":"03/27/2026","subject":"Feedback form"}],"crossReferences":{"chemblId":"CHEMBL5591580","pubchemSID":"485206018"},"formularyStatus":[],"_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[{"notes":"","period":"YYYY-present","_source":"Wikipedia","companyName":"Pfizer","relationship":"Originator"}],"publicationCount":4,"therapeuticAreas":["Infectious 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