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antifungals (voriconazole, ketoconazole, isavuconazonium sulfate, itraconazole) where significantly increased concentrations of antifungals may be expected.","Co-administration with sedative/hypnotics (midazolam) where significantly increased concentrations of sedative/hypnotics may be expected."],"specialPopulations":{"Pregnancy":"Women of childbearing potential should avoid becoming pregnant one menstrual cycle after stopping PAXLOVID. There are no human data on the use of PAXLOVID during pregnancy to inform the drug-associated risk of adverse developmental outcomes. PAXLOVID is not recommended during pregnancy and in women of childbearing potential not using contraception.","Geriatric use":"No specific guidance is provided for geriatric use.","Paediatric use":"The safety and efficacy of PAXLOVID in paediatric patients younger than 18 years of age have not yet been established. No data are available.","Renal impairment":"Mild: No dose adjustment is needed. Moderate: Reduce dose to PF-07321332/ritonavir 150 mg/100 mg every 12 hours. Severe: Contraindicated until more data are available.","Hepatic impairment":"Contraindicated in patients with severe hepatic impairment (Child-Pugh Class C)."}},"_chembl":null,"company":"Pfizer","patents":[{"title":"Compounds and methods for treating coronavirus infections","number":"US10961144B2","grantDate":"March 30, 2021","filingDate":"March 13, 2020"}],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=pf-07321332-dose-5","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:51:05.892936+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-19T23:51:05.892850+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:51:11.653047+00:00"},"regulatory.eu":{"url":"","method":"api_direct","source":"European Medicines Agency","rawText":"","confidence":1,"sourceType":"ema_api","retrievedAt":"2026-04-19T23:51:05.964508+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pf-07321332-dose-5","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:51:12.004918+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL5432119/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:51:13.212459+00:00"}},"allNames":"pf-07321332 dose 5","timeline":[{"date":"November 5, 2021","type":"Clinical","milestone":"Phase 2/3 trial interim results announced","regulator":"N/A"},{"date":"December 14, 2021","type":"Regulatory","milestone":"Emergency Use Authorization (EUA) submitted to FDA","regulator":"FDA"},{"date":"December 22, 2021","type":"Regulatory","milestone":"EUA granted by FDA","regulator":"FDA"}],"_dailymed":null,"aiSummary":"PF-07321332 is an investigational antiviral drug developed by Pfizer Inc. for the treatment of COVID-19. It is designed to inhibit the main protease (Mpro) of SARS-CoV-2, which is essential for viral replication. The drug is being evaluated in various clinical trials, including Phase 2/3 studies, and has shown promising results in reducing viral load and improving clinical outcomes. However, it does not have an FDA label yet, and its safety and efficacy are still under investigation. 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