{"id":"pf-05280014","safety":{"commonSideEffects":[{"rate":null,"effect":"Infusion-related reactions"},{"rate":null,"effect":"Cardiotoxicity / left ventricular dysfunction"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PF-05280014 is a monoclonal antibody designed as a biosimilar to trastuzumab (Herceptin), targeting human epidermal growth factor receptor 2 (HER2) expressed on cancer cells. By binding to HER2, it blocks HER2-mediated signaling and recruits immune cells to destroy HER2-positive tumor cells through antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC).","oneSentence":"PF-05280014 is a biosimilar of trastuzumab that binds to HER2 on cancer cells to inhibit growth and promote immune-mediated cell death.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:04.006Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"HER2-positive metastatic breast cancer"},{"name":"HER2-positive early-stage breast cancer"},{"name":"HER2-positive gastric cancer"}]},"trialDetails":[{"nctId":"NCT06136897","phase":"PHASE2","title":"Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)","status":"ACTIVE_NOT_RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2017-03-23","conditions":"Malignant Solid 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APPETITE"},{"count":1,"reaction":"DIARRHOEA"},{"count":1,"reaction":"DIZZINESS"}],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Trastuzumab-Pfizer"],"phase":"phase_3","status":"active","brandName":"PF-05280014","genericName":"PF-05280014","companyName":"Pfizer","companyId":"pfizer","modality":"Biologic","firstApprovalDate":"","aiSummary":"PF-05280014 is being studied in clinical trials for various breast cancer conditions, including HER2/Neu Positive, Recurrent Breast Carcinoma, Stage IV Breast Cancer, Metastatic Breast Cancer, and Anatomic Stage II Breast Cancer AJCC v8. The exact mechanism of PF-05280014 is unknown, but it is being investigated in combination with other interventions such as Pertuzumab.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":2},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}