{"id":"pet-scan-with-11c-abp688","safety":{"commonSideEffects":[{"rate":null,"effect":"Radiation exposure (minimal from diagnostic dose)"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"[11C]ABP688 is a carbon-11 labeled radiotracer designed to selectively bind to mGluR5, a G-protein coupled receptor involved in glutamatergic neurotransmission. The radioactive carbon-11 allows visualization of mGluR5 distribution and density in the central nervous system using PET imaging. This enables non-invasive assessment of mGluR5 availability in neurological and psychiatric disorders.","oneSentence":"[11C]ABP688 is a positron emission tomography (PET) tracer that binds to metabotropic glutamate receptor 5 (mGluR5) to enable imaging of mGluR5 expression in the brain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:52.670Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"PET imaging of mGluR5 expression in the brain for research and diagnostic purposes"},{"name":"Investigation of neurological and psychiatric disorders including Alzheimer's disease, Parkinson's disease, and schizophrenia"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":104,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"PET Scan with [11C]ABP688","genericName":"PET Scan with [11C]ABP688","companyName":"Stony Brook University","companyId":"stony-brook-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"[11C]ABP688 is a positron emission tomography (PET) tracer that binds to metabotropic glutamate receptor 5 (mGluR5) to enable imaging of mGluR5 expression in the brain. Used for PET imaging of mGluR5 expression in the brain for research and diagnostic purposes, Investigation of neurological and psychiatric disorders including Alzheimer's disease, Parkinson's disease, and schizophrenia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}