{"id":"pertussis-containing-vaccine","safety":{"commonSideEffects":[{"rate":"10–50","effect":"Local injection site reactions (pain, redness, swelling)"},{"rate":"5–15","effect":"Fever"},{"rate":"5–10","effect":"Irritability or fussiness"},{"rate":"5–10","effect":"Drowsiness"},{"rate":"5–10","effect":"Loss of appetite"}]},"_chembl":{"chemblId":"CHEMBL2109219","moleculeType":"Vaccine component"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The vaccine contains inactivated pertussis toxin and other bacterial antigens that trigger both humoral (antibody) and cell-mediated immune responses. This primes the immune system to recognize and rapidly eliminate B. pertussis upon natural exposure, preventing infection or reducing disease severity. Pertussis vaccines are typically combined with diphtheria and tetanus toxoids (DPT or Tdap formulations).","oneSentence":"A pertussis-containing vaccine stimulates the immune system to produce antibodies and cellular immunity against Bordetella pertussis, the bacterium that causes whooping cough.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:34:13.620Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention of pertussis (whooping cough) in infants, children, and adults"},{"name":"Prevention of diphtheria and tetanus (when in combination formulations)"}]},"trialDetails":[{"nctId":"NCT07160244","phase":"PHASE3","title":"BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies","status":"RECRUITING","sponsor":"Pfizer","startDate":"2025-08-25","conditions":"Healthy","enrollment":6000},{"nctId":"NCT05856396","phase":"PHASE4","title":"Maternal Determinants of Infant Immunity to Pertussis","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire Saint Pierre","startDate":"2023-09-12","conditions":"Vaccination; Infection, Maternal-Fetal Relations, Pertussis","enrollment":200},{"nctId":"NCT06798831","phase":"PHASE3","title":"Study Evaluating the Safety of a Recombinant Acellular Pertussis Vaccine in Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"BioNet-Asia Co., Ltd.","startDate":"2025-02-08","conditions":"Pertussis Vaccine","enrollment":2399},{"nctId":"NCT06879327","phase":"PHASE2","title":"Infant Malaria Vaccine Schedule Optimization","status":"RECRUITING","sponsor":"PATH","startDate":"2025-05-30","conditions":"Malaria Vaccines","enrollment":1200},{"nctId":"NCT06803524","phase":"PHASE4","title":"10-year Follow-up After a Single Dose Acellular Pertussis Vaccination","status":"RECRUITING","sponsor":"Mahidol University","startDate":"2025-05-13","conditions":"Pertussis","enrollment":126},{"nctId":"NCT03562377","phase":"PHASE2","title":"Vaccine Responses in Tralokinumab-Treated Atopic Dermatitis - ECZTRA 5 (ECZema TRAlokinumab Trial No. 5)","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2018-07-13","conditions":"Atopic Dermatitis","enrollment":215},{"nctId":"NCT06748612","phase":"PHASE4","title":"Immunogenicity of Different Primary Immunization Schedules with Inactivated Poliovirus Vaccine (IPV) Plus Pentavalent Vaccine (DTwP-HBV-Hib) or with Hexavalent Vaccine (DTwP-HBV-Hib-IPV)","status":"NOT_YET_RECRUITING","sponsor":"International Centre for Diarrhoeal Disease Research, Bangladesh","startDate":"2025-01-28","conditions":"Polio","enrollment":1190},{"nctId":"NCT03457194","phase":"","title":"Optimising Protection for Pregnant Women and Infants With Maternal Vaccination","status":"UNKNOWN","sponsor":"Women's and Children's Hospital, Australia","startDate":"2018-08-28","conditions":"Obesity","enrollment":73},{"nctId":"NCT04589312","phase":"PHASE2","title":"Maternal Pertussis Wholecell Responses","status":"COMPLETED","sponsor":"St George's, University of London","startDate":"2020-10-21","conditions":"Pertussis","enrollment":181},{"nctId":"NCT03620162","phase":"PHASE3","title":"A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy Infants (V114-027/PNEU-DIRECTION)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2018-10-18","conditions":"Pneumococcal Infections","enrollment":900},{"nctId":"NCT03147898","phase":"","title":"Observational Study Describing the Immune Profile Induced By Pertussis Vaccines","status":"COMPLETED","sponsor":"Sanofi","startDate":"2017-04-12","conditions":"Whooping Cough, Pertussis","enrollment":90},{"nctId":"NCT03578120","phase":"","title":"Immunising Mums Against Pertussis 3","status":"COMPLETED","sponsor":"St George's, University of London","startDate":"2018-04-24","conditions":"Whooping Cough, Maternal Vaccine Exposure, Immunization; Infection","enrollment":64},{"nctId":"NCT05193734","phase":"PHASE2, PHASE3","title":"Safety and Immunogenicity of 2 Doses Versus 1 Dose of Acellular Pertussis Vaccines Containing Genetically-detoxified Pertussis Toxin in Young Adults Previously Primed With Acellular Pertussis Vaccines","status":"UNKNOWN","sponsor":"University Hospital, Geneva","startDate":"2022-02-07","conditions":"Pertussis, Vaccine-Preventable Diseases","enrollment":100},{"nctId":"NCT04529720","phase":"","title":"5-year Follow-up After a Single Dose Acellular Pertussis Vaccination","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2020-08-24","conditions":"Pertussis","enrollment":159},{"nctId":"NCT03908164","phase":"PHASE4","title":"Optimising the Timing of Whooping Cough Immunisation in MUMs","status":"UNKNOWN","sponsor":"St George's, University of London","startDate":"2019-05-07","conditions":"Pregnancy Related, Immunization; Infection, Pertussis","enrollment":354},{"nctId":"NCT02511327","phase":"","title":"Pertussis Immunization During Pregnancy: Effect in Term and Preterm Infants","status":"UNKNOWN","sponsor":"Universiteit Antwerpen","startDate":"2015-01","conditions":"Pertussis","enrollment":232},{"nctId":"NCT03284515","phase":"","title":"Vaccination In Pregnancy Gene Signature: VIP Signature Study","status":"COMPLETED","sponsor":"St George's, University of London","startDate":"2017-09-07","conditions":"Pregnancy Related, Vaccination","enrollment":30},{"nctId":"NCT02145624","phase":"PHASE4","title":"A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants","status":"COMPLETED","sponsor":"Public Health England","startDate":"2014-10","conditions":"Responses to Infant Immunisations","enrollment":366},{"nctId":"NCT01698346","phase":"PHASE4","title":"Pertussis (Tdap) Vaccination in Pregnancy","status":"COMPLETED","sponsor":"Universiteit Antwerpen","startDate":"2012-02","conditions":"Pertussis, Pregnancy","enrollment":99},{"nctId":"NCT02408926","phase":"PHASE4","title":"Vaccine Responses in Infants After Acellular Pertussis Vaccination During Pregnancy in Thailand","status":"COMPLETED","sponsor":"Universiteit Antwerpen","startDate":"2015-04","conditions":"Pertussis","enrollment":370},{"nctId":"NCT02097472","phase":"PHASE1, PHASE2","title":"Dose-Finding Study of S.Pneumoniae Whole Cell Vaccine Adsorbed to Alum (PATH-wSP) in Healthy Kenyan Adults and Toddlers","status":"COMPLETED","sponsor":"PATH","startDate":"2014-04","conditions":"Pneumonia, Pneumococcal","enrollment":304},{"nctId":"NCT04113655","phase":"","title":"2-year Follow-up After a Single Dose Acellular Pertussis Vaccination","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2017-06-20","conditions":"Pertussis","enrollment":180},{"nctId":"NCT04102137","phase":"","title":"3-year Follow-up After a Single Dose Acellular Pertussis Vaccination","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2018-06-26","conditions":"Pertussis","enrollment":181},{"nctId":"NCT03982732","phase":"","title":"Maternal Antibody in Milk After Vaccination","status":"UNKNOWN","sponsor":"St George's, University of London","startDate":"2018-08-07","conditions":"Pertussis, Vaccination, Pregnancy","enrollment":50},{"nctId":"NCT00385255","phase":"PHASE3","title":"Immunogenicity, Safety of GSKs Tdap Vaccine Boostrix When Coadministered With GSKs Influenza Vaccine Fluarix in Adults","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-10-23","conditions":"Acellular Pertussis, Diphtheria, Tetanus","enrollment":1726},{"nctId":"NCT01480258","phase":"PHASE3","title":"Safety, Tolerability, and Immunogenicity of V419 in Healthy Infants When Given at 2, 4, and 11 to 12 Months (V419-008)","status":"COMPLETED","sponsor":"MCM Vaccines B.V.","startDate":"2011-11-23","conditions":"Bacterial Infections, Virus Diseases","enrollment":1315},{"nctId":"NCT02526394","phase":"PHASE4","title":"Pertussis and Meningitis C Concomitant Vaccination in Adolescents","status":"COMPLETED","sponsor":"Public Health England","startDate":"2013-09","conditions":"Pertussis, Meningitis, Preventive Immunization; Meningitis","enrollment":400},{"nctId":"NCT01926015","phase":"PHASE4","title":"Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2013-09-19","conditions":"Rotavirus Disease","enrollment":192},{"nctId":"NCT00310856","phase":"PHASE2","title":"Immunogenicity and Safety of MenACWY in Infants (6 & 12 Months)","status":"COMPLETED","sponsor":"Novartis Vaccines","startDate":"2005-06","conditions":"Meningococcal Meningitis","enrollment":175},{"nctId":"NCT00282295","phase":"PHASE4","title":"US-licensed Combined Vaccine Against Tetanus & Diphtheria, Given With US-licensed Vaccine Against Meningococcal Disease","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-01-25","conditions":"Acellular Pertussis, Tetanus, Diphtheria","enrollment":1344},{"nctId":"NCT00627458","phase":"PHASE2","title":"Immunogenicity and Reactogenicity of a Booster Dose of GSK Bio's DTPa-HBV-IPV/Hib Vaccine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-02-01","conditions":"Acellular Pertussis, Diphtheria, Poliomyelitis","enrollment":403},{"nctId":"NCT00432042","phase":"PHASE3","title":"Immunogenicity and Safety Study of Proquad® and Infanrix® Hexa When Administered Concomitantly (V221-035)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2007-01-12","conditions":"Varicella, Measles, Mumps","enrollment":955},{"nctId":"NCT01287949","phase":"PHASE3","title":"Safety and Immunogenicity Study of a Diphtheria, Tetanus, Acellular Pertussis and Poliomyelitis Vaccine (REPEVAX) Followed by 2 Doses of a Diphtheria, Tetanus and Poliomyelitis Vaccine (REVAXIS) in Subjects of 40 Years of Age or Older","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2011-01","conditions":"Diphtheria, Tetanus, Poliomyelitis","enrollment":342},{"nctId":"NCT00376779","phase":"PHASE2","title":"Immunogenicity and Safety of a DTPa-HBV-IPV/Hib Vaccine Given at 2, 3 and 4 Months of Age","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-10","conditions":"Acellular Pertussis, Tetanus, Diphtheria","enrollment":450},{"nctId":"NCT00263679","phase":"PHASE3","title":"Assessment of GSK Biologicals' Tdap Candidate Vaccine Administered as a Booster (6th Dose) in Terms of Immunogenicity and Safety to Children and Adolescents Previously Vaccinated With Five Doses of an Acellular Pertussis-containing Vaccine.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2003-11","conditions":"Acellular Pertussis, Diphtheria, Tetanus","enrollment":321},{"nctId":"NCT01529645","phase":"PHASE1","title":"Safety and Dose Ranging Study of Acellular Pertussis and Acellular Pertussis -Tetanus-Diphtheria Booster Vaccines in Healthy Adults Ages 18 to 40 Years","status":"COMPLETED","sponsor":"Novartis Vaccines","startDate":"2012-03","conditions":"Pertussis, Whooping Cough, Tetanus","enrollment":420},{"nctId":"NCT02382913","phase":"PHASE1","title":"Persistency Study After aP / Tdap Booster Vaccines in Adult Subjects (V113_01 Extension 1)","status":"COMPLETED","sponsor":"Novartis","startDate":"2015-04","conditions":"Pertussis","enrollment":315},{"nctId":"NCT00551629","phase":"PHASE2","title":"A Study to Test the Safety and Effectiveness of an Investigational Vaccine in Infants (V419-002)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2001-05","conditions":"Bacterial Infections; Virus Diseases","enrollment":708},{"nctId":"NCT00551915","phase":"PHASE2","title":"A Study of the Safety and Tolerability of V419 in Healthy Infants at 2,4, 6 and 12 to 14 Months of Age (V419-003)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2001-05","conditions":"Bacterial Infections; Virus Diseases","enrollment":756},{"nctId":"NCT01003431","phase":"PHASE3","title":"A Study of the Immunogenicity and Safety of Whole-Cell Pertussis Containing Vaccine Administered Concomitantly With RotaTeq™ (V260) or Rotarix™ (V260-036)(WITHDRAWN)","status":"WITHDRAWN","sponsor":"Merck Sharp & Dohme LLC","startDate":"2009-12","conditions":"Rotavirus Gastroenteritis, Diphtheria, Tetanus","enrollment":""},{"nctId":"NCT00325130","phase":"PHASE3","title":"Concomitant Use of Gardasil (V501) (Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) With Combined Diphtheria, Tetanus, Pertussis Vaccine and Meningococcal Conjugate Vaccine in Adolescents (V501-025)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2006-04","conditions":"Neoplasms, Glandular and Epithelial, Diphtheria, Tetanus","enrollment":1042},{"nctId":"NCT01000311","phase":"PHASE3","title":"A Study to Evaluate the Safety and Immunogenicity of 4 Doses of MenACWY Conjugate Vaccine, Administered Concomitantly With Routine Vaccines, Among Infants Aged 2 Months","status":"COMPLETED","sponsor":"Novartis Vaccines","startDate":"2009-11","conditions":"Meningococcal Disease","enrollment":529},{"nctId":"NCT01445743","phase":"PHASE2","title":"Immunogenicity and Safety of an Acellular DPT Vaccine During Pregnancy","status":"COMPLETED","sponsor":"Hospital Universitario Dr. Jose E. Gonzalez","startDate":"2011-09","conditions":"Pregnancy","enrollment":204},{"nctId":"NCT01424644","phase":"PHASE4","title":"A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents","status":"COMPLETED","sponsor":"Novartis","startDate":"2011-09","conditions":"Meningococcal Meningitis","enrollment":801},{"nctId":"NCT01362517","phase":"PHASE3","title":"Study of Quinvaxem for Vaccination Against Diphtheria, Pertussis, Tetanus, Hepatitis B and Diseases Caused by Haemophilus Influenzae Type B","status":"COMPLETED","sponsor":"Crucell Holland BV","startDate":"2010-04","conditions":"Diphtheria, Pertussis, Tetanus","enrollment":131},{"nctId":"NCT01357720","phase":"PHASE4","title":"Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination","status":"COMPLETED","sponsor":"Crucell Holland BV","startDate":"2011-05","conditions":"Diphtheria, Pertussis, Tetanus","enrollment":400},{"nctId":"NCT00342628","phase":"PHASE2","title":"Safety, Immunogenicity and Compatibility With DTP of a Typhoid Fever Vaccine in Infants","status":"COMPLETED","sponsor":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","startDate":"2006-07","conditions":"Typhoid Fever","enrollment":301},{"nctId":"NCT00004800","phase":"PHASE3","title":"Phase III Randomized, Double-Blind, Placebo-Controlled Study of Acellular and Whole-Cell Pertussis Vaccines","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"1992-09","conditions":"Pertussis","enrollment":13250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Boostrix, Repevax"],"phase":"marketed","status":"active","brandName":"Pertussis containing vaccine","genericName":"Pertussis containing vaccine","companyName":"St George's, University of London","companyId":"st-george-s-university-of-london","modality":"Biologic","firstApprovalDate":"","aiSummary":"A pertussis-containing vaccine stimulates the immune system to produce antibodies and cellular immunity against Bordetella pertussis, the bacterium that causes whooping cough. Used for Prevention of pertussis (whooping cough) in infants, children, and adults, Prevention of diphtheria and tetanus (when in combination formulations).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}