{"id":"permethrin-cream-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Pruritus (itching)"},{"rate":null,"effect":"Erythema (redness)"},{"rate":null,"effect":"Burning or stinging sensation"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":{"setId":"e3d77092-dad6-4df5-ac39-ff9dc8f5758c","title":"PERMETHRIN (PERMETHRIN CREAM 5% W/W) CREAM [REMEDYREPACK INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Permethrin acts as a neurotoxin by binding to voltage-gated sodium channels in nerve cell membranes of insects and mites, preventing normal sodium ion flow and causing repetitive nerve firing, paralysis, and ultimately death of the parasite. The drug is selectively toxic to arthropods due to their greater sensitivity to sodium channel disruption compared to mammals. It is applied topically to the skin where it kills scabies mites and lice on contact.","oneSentence":"Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasitic arthropods, causing paralysis and death.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:39.011Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Scabies (Sarcoptes scabiei infestation)"},{"name":"Head lice (Pediculus humanus capitis)"},{"name":"Body lice (Pediculus humanus humanus)"},{"name":"Pubic lice (Phthirus pubis)"}]},"trialDetails":[{"nctId":"NCT04332068","phase":"PHASE2","title":"Ivermectin Safety in Small Children","status":"COMPLETED","sponsor":"University of Oxford","startDate":"2023-11-18","conditions":"Scabies","enrollment":240},{"nctId":"NCT07159373","phase":"PHASE3","title":"Better Options for Lymphatic Filariasis Treatment","status":"NOT_YET_RECRUITING","sponsor":"Medicines Development for Global Health","startDate":"2026-03","conditions":"Lymphatic Filariasis, Scabies, Strongyloidiasis","enrollment":5100},{"nctId":"NCT06896929","phase":"PHASE2","title":"Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies","status":"NOT_YET_RECRUITING","sponsor":"Children Hospital and Institute of Child Health, Lahore","startDate":"2025-05-01","conditions":"Scabies","enrollment":90},{"nctId":"NCT02407782","phase":"PHASE3","title":"Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children and Adults","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2016-01-19","conditions":"Scabies","enrollment":1092},{"nctId":"NCT06380452","phase":"PHASE3","title":"Therapy for Scabies With Two Differently Concentrated Permethrin Creams","status":"NOT_YET_RECRUITING","sponsor":"Infectopharm Arzneimittel GmbH","startDate":"2024-05","conditions":"Scabies","enrollment":220},{"nctId":"NCT02841215","phase":"PHASE3","title":"Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-10-11","conditions":"Gale, Severe Forms of Scabies, Oral Parasitic Drug","enrollment":133},{"nctId":"NCT05862701","phase":"PHASE1","title":"Comparison of Topical 5% Permethrin and Topical 10% Sulfur in the Treatment of Scabies","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-03-01","conditions":"Scabies","enrollment":60},{"nctId":"NCT05819983","phase":"PHASE4","title":"Ivermectin/ Permethrin for Scabies","status":"COMPLETED","sponsor":"Universitas Padjadjaran","startDate":"2023-01-25","conditions":"Scabies","enrollment":60},{"nctId":"NCT05362513","phase":"PHASE1","title":"Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2021-06-01","conditions":"Scabies","enrollment":100},{"nctId":"NCT03177993","phase":"NA","title":"Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji","status":"COMPLETED","sponsor":"Washington University School of Medicine","startDate":"2017-07-13","conditions":"Lymphatic Filariases, Scabies, Impetigo","enrollment":4773},{"nctId":"NCT03973775","phase":"PHASE3","title":"A Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies","status":"COMPLETED","sponsor":"Saptalis Pharmaceuticals LLC","startDate":"2018-04-10","conditions":"Scabies","enrollment":126},{"nctId":"NCT02978508","phase":"PHASE3","title":"Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies.","status":"COMPLETED","sponsor":"Mayne Pharma International Pty Ltd","startDate":"2016-11","conditions":"Scabies","enrollment":140},{"nctId":"NCT03236168","phase":"PHASE3","title":"Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2017-08-01","conditions":"Scabies, Head Lice","enrollment":118},{"nctId":"NCT03178942","phase":"PHASE3","title":"Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies","status":"COMPLETED","sponsor":"Encube Ethicals Pvt. Ltd.","startDate":"2017-06-01","conditions":"Scabies","enrollment":254},{"nctId":"NCT02572986","phase":"PHASE3","title":"A Study to Evaluate the Therapeutic Equivalence of Generic Permethrin Cream 5% to Elimite® in the Treatment of Scabies","status":"COMPLETED","sponsor":"Dr. Reddy's Laboratories Limited","startDate":"2015-09","conditions":"Scabies","enrollment":250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Permethrin Cream, 5%","genericName":"Permethrin Cream, 5%","companyName":"Mayne Pharma International Pty Ltd","companyId":"mayne-pharma-international-pty-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Permethrin is a synthetic pyrethroid insecticide that disrupts sodium channel function in the nervous system of parasitic arthropods, causing paralysis and death. Used for Scabies (Sarcoptes scabiei infestation), Head lice (Pediculus humanus capitis), Body lice (Pediculus humanus humanus).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}