{"id":"periprocedural-antibiotics","safety":{"commonSideEffects":[{"rate":"1-3%","effect":"Allergic reaction (rash, urticaria)"},{"rate":"2-5%","effect":"Gastrointestinal disturbance (nausea, diarrhea)"},{"rate":"0.01-0.1%","effect":"Anaphylaxis (with beta-lactams)"},{"rate":"0.5-2%","effect":"Clostridioides difficile infection"}]},"_chembl":{"chemblId":"CHEMBL413713","moleculeType":"Small molecule","molecularWeight":"1527.48"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Periprocedural antibiotics are administered before, during, or shortly after surgical or invasive procedures to achieve adequate tissue and serum concentrations at the time of incision, reducing the risk of surgical site infections (SSIs). The timing and choice of antibiotic depend on the procedure type, patient risk factors, and local resistance patterns. These are standard prophylactic measures rather than a single drug entity.","oneSentence":"Periprocedural antibiotics prevent surgical site infections by providing antimicrobial coverage during and immediately after medical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:57.981Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Surgical site infection prophylaxis in general surgery"},{"name":"Surgical site infection prophylaxis in orthopedic procedures"},{"name":"Surgical site infection prophylaxis in cardiac surgery"},{"name":"Surgical site infection prophylaxis in vascular surgery"}]},"trialDetails":[{"nctId":"NCT07449559","phase":"NA","title":"Nursing Intervention Guided by an ICD Nursing Guideline","status":"COMPLETED","sponsor":"Hacettepe University","startDate":"2021-08-16","conditions":"Implantable Cardioverter-defibrillators (ICDs)","enrollment":60},{"nctId":"NCT03508921","phase":"PHASE4","title":"Comparison of Methods for Prevention of Urinary Tract Infection Following Botox Injection","status":"TERMINATED","sponsor":"Vanderbilt University Medical Center","startDate":"2018-07-01","conditions":"Overactive Bladder, Urinary Tract Infections","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["trimethoprim/sulfamethoxazole"],"phase":"marketed","status":"active","brandName":"Periprocedural Antibiotics","genericName":"Periprocedural Antibiotics","companyName":"Vanderbilt University Medical Center","companyId":"vanderbilt-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Periprocedural antibiotics prevent surgical site infections by providing antimicrobial coverage during and immediately after medical procedures. Used for Surgical site infection prophylaxis in general surgery, Surgical site infection prophylaxis in orthopedic procedures, Surgical site infection prophylaxis in cardiac surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}