{"id":"peripheral-intravenous-norepinephrine","safety":{"commonSideEffects":[{"rate":null,"effect":"Extravasation injury / tissue necrosis"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Norepinephrine acts as a sympathomimetic agent, stimulating alpha-1 adrenergic receptors to cause vasoconstriction and beta-1 adrenergic receptors to increase heart rate and contractility. When administered via peripheral intravenous line (rather than central line), this represents a clinical approach to managing hypotensive states in acute care settings, though peripheral administration carries higher risk of extravasation injury.","oneSentence":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase blood pressure and cardiac output, used peripherally to treat hypotension.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:35.003Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypotension in acute care / septic shock (peripheral administration)"},{"name":"Cardiogenic shock"}]},"trialDetails":[{"nctId":"NCT05179499","phase":"PHASE3","title":"Early Vasopressors in Sepsis","status":"RECRUITING","sponsor":"NHS Greater Glasgow and Clyde","startDate":"2022-10-11","conditions":"Sepsis","enrollment":1006},{"nctId":"NCT06885268","phase":"PHASE3","title":"Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery","status":"RECRUITING","sponsor":"Jagiellonian University","startDate":"2025-06-25","conditions":"Blood Pressure Management, Intraoperative Hypotension, Non-cardiac Surgery","enrollment":750},{"nctId":"NCT07235514","phase":"NA","title":"Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2","status":"NOT_YET_RECRUITING","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2025-12-01","conditions":"Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia","enrollment":958},{"nctId":"NCT06059144","phase":"PHASE3","title":"Induced Hypertension in Acute PRogrESsive Perforating Artery Stroke Using Peripheral Dilute noREpinephrine","status":"RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2024-11-28","conditions":"Stroke, Acute, Stroke, Ischemic","enrollment":358},{"nctId":"NCT05836272","phase":"PHASE4","title":"Early Administration of Norepinephrine in Sepsis","status":"RECRUITING","sponsor":"Tunis University","startDate":"2023-08-01","conditions":"Sepsis, Severe","enrollment":200},{"nctId":"NCT04560634","phase":"","title":"Diastolic Performance and Norepinephrine in Spinal-Induced Hypotension for Cesarean Delivery","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2020-01-14","conditions":"Hypotension","enrollment":40},{"nctId":"NCT02428062","phase":"PHASE2, PHASE3","title":"Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly","status":"SUSPENDED","sponsor":"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","startDate":"2014-10","conditions":"Post-operative Cognitive Dysfunction","enrollment":1812},{"nctId":"NCT02414555","phase":"PHASE4","title":"Perioperative Fluid Management in Patients Receiving Major Abdominal Surgery - Effects of Normal Saline Versus an Acetate Buffered Balanced Infusion Solution on the Necessity of Catecholamines for Cardiocirculatory Support","status":"TERMINATED","sponsor":"Medical University of Vienna","startDate":"2015-03","conditions":"Critical Illness","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Peripheral intravenous norepinephrine","genericName":"Peripheral intravenous norepinephrine","companyName":"University Hospital, Bordeaux","companyId":"university-hospital-bordeaux","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Norepinephrine is a catecholamine that binds to alpha and beta adrenergic receptors to increase blood pressure and cardiac output, used peripherally to treat hypotension. Used for Hypotension in acute care / septic shock (peripheral administration), Cardiogenic shock.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}