{"id":"perioperative-mflot","safety":{"commonSideEffects":[{"rate":"20-40%","effect":"Neutropenia"},{"rate":"10-30%","effect":"Thrombocytopenia"},{"rate":"20-40%","effect":"Anemia"},{"rate":"30-60%","effect":"Nausea and vomiting"},{"rate":"20-40%","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The mFLOT regimen combines multiple chemotherapy drugs to target rapidly dividing cancer cells. This approach aims to maximize the effectiveness of treatment while minimizing side effects. The specific combination of drugs in mFLOT allows for a tailored approach to cancer treatment, taking into account the individual patient's needs and cancer type.","oneSentence":"Perioperative mFLOT is a chemotherapy regimen used to treat various types of cancer.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:31.009Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastric adenocarcinoma"},{"name":"Esophageal adenocarcinoma"},{"name":"Esophageal squamous cell carcinoma"}]},"trialDetails":[{"nctId":"NCT03961841","phase":"PHASE3","title":"Perioperative Combination Chemotherapy Versus Chemoradiation for Locally Advanced EGJ Adenocarcinoma","status":"NOT_YET_RECRUITING","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2020-06","conditions":"Esophagogastric Junction Disorder, Neoplasms","enrollment":900}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Perioperative mFLOT","genericName":"Perioperative mFLOT","companyName":"Sixth Affiliated Hospital, Sun Yat-sen University","companyId":"sixth-affiliated-hospital-sun-yat-sen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Perioperative mFLOT is a chemotherapy regimen being studied for the treatment of Esophagogastric Junction Disorder and Neoplasms. It is being compared to chemoradiation with weekly 5Fu and oxaliplatin, as well as Perioperative FOLFOX, in a randomized controlled trial for locally advanced EGJ adenocarcinoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}