{"id":"perineural-dexmedetomidine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Dry mouth"}]},"_chembl":{"chemblId":"CHEMBL2106195","moleculeType":"Small molecule","molecularWeight":"236.75"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexmedetomidine binds to alpha-2 adrenergic receptors on nerve fibers, blocking pain signal transmission when delivered in the perineural space adjacent to target nerves. This produces extended sensory and motor blockade lasting several hours beyond the duration of conventional local anesthetics, reducing postoperative pain and opioid requirements.","oneSentence":"Perineural dexmedetomidine is an alpha-2 adrenergic agonist administered around nerves to provide prolonged local anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:37:17.041Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perineural nerve block adjunct for postoperative analgesia"},{"name":"Regional anesthesia enhancement in pediatric and adult surgical procedures"}]},"trialDetails":[{"nctId":"NCT07316166","phase":"PHASE4","title":"Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine","status":"RECRUITING","sponsor":"Rhode Island Hospital","startDate":"2026-01-20","conditions":"Postoperative Pain Management","enrollment":120},{"nctId":"NCT07327931","phase":"NA","title":"PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-13","conditions":"Hip Osteoarthritis, Hip Pain Chronic","enrollment":120},{"nctId":"NCT07330999","phase":"NA","title":"Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-13","conditions":"Hip Osteoarthritis","enrollment":120},{"nctId":"NCT07327372","phase":"NA","title":"PENG Block With Dexmedetomidine in Older Adults","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-02-06","conditions":"Hip Osteoarthritis, Arthropathy of Hip","enrollment":30},{"nctId":"NCT07386600","phase":"NA","title":"Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-01-01","conditions":"Knee Osteoarthritis","enrollment":96},{"nctId":"NCT07289620","phase":"NA","title":"Dexamethasone vs Dexmedetomidine vs Combination as Adjuvants to Popliteal Sciatic Nerve Block in Children","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2026-01-16","conditions":"Ankle Disease, Foot Diseases","enrollment":120},{"nctId":"NCT07299877","phase":"PHASE4","title":"Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block","status":"NOT_YET_RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-12-28","conditions":"Brachial Plexus Blocks","enrollment":75},{"nctId":"NCT07249827","phase":"PHASE2","title":"A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block","status":"RECRUITING","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2025-12-28","conditions":"Analgesia, Pain, Acute, Upper Extremity Surgery","enrollment":69},{"nctId":"NCT07180940","phase":"PHASE4","title":"Comparison of Perineural Dexamethasone Versus Dexmedetomidine as Adjuvants to Erector Spinae Plane Block in Lumbar Spine Surgery: A Randomized, Double-blind, Controlled Trial","status":"RECRUITING","sponsor":"Poznan University of Medical Sciences","startDate":"2025-09-01","conditions":"Spine Disease, Spinal Diseases","enrollment":150},{"nctId":"NCT06304324","phase":"PHASE4","title":"Dexmedetomidine Vs Dexamethasone in Popliteal Nerve Block","status":"UNKNOWN","sponsor":"Poznan University of Medical Sciences","startDate":"2024-05-06","conditions":"Ankle Disease, Ankle Injuries and Disorders, Foot Injury","enrollment":90},{"nctId":"NCT05775861","phase":"NA","title":"Dexmedetomidine Added to Ropivacaine Single Shot vs Continuous Interscalene Nerve Block","status":"UNKNOWN","sponsor":"Ciusss de L'Est de l'Île de Montréal","startDate":"2022-08-23","conditions":"Anesthesia, Shoulder Pain, Post Operative Pain","enrollment":96},{"nctId":"NCT05215158","phase":"NA","title":"Intravenous Versus Peribulbar Dexmedetomidine for Strabismus Surgery in Adults","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2022-01-28","conditions":"Squint","enrollment":46},{"nctId":"NCT04208516","phase":"PHASE4","title":"Continuous Nerve Block Block vs Combination of Single Block Plus Intravenous Lidocaine for Postoperative Pain.","status":"TERMINATED","sponsor":"Jeremy Kearns","startDate":"2021-05-26","conditions":"Postoperative Pain","enrollment":17},{"nctId":"NCT04266145","phase":"NA","title":"Intravenous Versus Perineural Dexmedetomidine as Adjuvant in Adductor Canal Block for Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2020-02-29","conditions":"Post Spinal Anesthesia Shivering","enrollment":56},{"nctId":"NCT04875039","phase":"PHASE4","title":"Dexametasone Versus Dexametasone Plus Dexmedetomidine in Nerve Blocks","status":"COMPLETED","sponsor":"University of Chile","startDate":"2021-08-31","conditions":"Analgesia, Pain, Acute, Upper Extremity Injury","enrollment":50},{"nctId":"NCT04694105","phase":"NA","title":"Peri-neural Dexmedetomidine Versus Dexamethasone for Supraaclavicular Block Adjuvant to Bupivacaine Supraclavicular Brachial Plexus Block","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-06-01","conditions":"Brachial Plexus Block","enrollment":42},{"nctId":"NCT03885804","phase":"EARLY_PHASE1","title":"Perineural Versus IV Dexmedetomidine as Adjuvant to Quadratus Lamborum Block for Pediatrics Undergoing Pyeloplasty","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2019-03-20","conditions":"Pain, Postoperative","enrollment":50},{"nctId":"NCT03610893","phase":"NA","title":"Dexamethasone Versus Dexmedetomidine as Adjuvants for Nerve Blocks","status":"COMPLETED","sponsor":"University of Chile","startDate":"2018-08-16","conditions":"Pain, Postoperative, Pain, Acute, Upper Extremity Injury","enrollment":120},{"nctId":"NCT03030950","phase":"PHASE4","title":"Perineural Dexmedetomidine in Adductor Canal Block","status":"COMPLETED","sponsor":"Cairo University","startDate":"2018-01-25","conditions":"Arthroscopic Medial Meniscectomy","enrollment":40},{"nctId":"NCT03393403","phase":"NA","title":"Comparison of the Effect of Intravenous and Perineural Dexmedetomidine in Gastric Cancer Surgery","status":"UNKNOWN","sponsor":"Kaohsiung Medical University Chung-Ho Memorial Hospital","startDate":"2017-12-23","conditions":"Gastric Cancer, Pain, Postoperative","enrollment":90},{"nctId":"NCT03222323","phase":"PHASE2","title":"Perineural Dexmedetomidine for Ulnar Nerve Block.","status":"UNKNOWN","sponsor":"Zealand University Hospital","startDate":"2017-07-17","conditions":"Healthy","enrollment":22},{"nctId":"NCT02550782","phase":"NA","title":"Infraclavicular Perineural Dexmedetomidine","status":"COMPLETED","sponsor":"Cukurova University","startDate":"2015-09","conditions":"The Analgesic Effects","enrollment":60},{"nctId":"NCT02781246","phase":"PHASE4","title":"Effect of Perineural Dexmedetomidine on the ED50 Ropivacaine for Brachial Plexus Blocks in Pediatric Patients: a Randomized Trial","status":"UNKNOWN","sponsor":"Guangzhou Women and Children's Medical Center","startDate":"2016-09","conditions":"Dose-Response Relationship, Drug","enrollment":160},{"nctId":"NCT02397603","phase":"PHASE2","title":"Peri-neural Dexmedetomidine as an Adjuvant to Bupivacaine Induced Paravertebral Block in Patients Undergonig Thoracotomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2015-02","conditions":"Acute Post-thoracotomy Pain","enrollment":40},{"nctId":"NCT02488473","phase":"PHASE2","title":"Does Perineural Dexmedetomidine Prolong Duration of a Nerve Block?","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2015-08","conditions":"Healthy","enrollment":21},{"nctId":"NCT01964040","phase":"PHASE4","title":"Perineural Dexmedetomidine and Femoral Nerve Block","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2013-08","conditions":"Onset and Duration of Sensory and Motor Block of Femoral Nerve,, Visual Analogue Pain Scores,, Time to First Request of Rescue Analgesics,","enrollment":45},{"nctId":"NCT01557270","phase":"PHASE3","title":"Efficacy and Safety Study of Dexmedetomidine as an Additive to Local Anesthetics in Shoulder Surgery","status":"COMPLETED","sponsor":"Prof. Peter Gerner, M.D.","startDate":"2012-03","conditions":"Drug Safety, Self Efficacy","enrollment":62}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":61,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"perineural dexmedetomidine","genericName":"perineural dexmedetomidine","companyName":"Guangzhou Women and Children's Medical Center","companyId":"guangzhou-women-and-children-s-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Perineural dexmedetomidine is an alpha-2 adrenergic agonist administered around nerves to provide prolonged local anesthesia and analgesia. Used for Perineural nerve block adjunct for postoperative analgesia, Regional anesthesia enhancement in pediatric and adult surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}