{"id":"perindopril-amlodipine-if-necessary-hydrochlorothiazide","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Cough"},{"rate":"5-15","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Peripheral edema"},{"rate":"3-8","effect":"Fatigue"},{"rate":"null","effect":"Hyperuricemia"},{"rate":"null","effect":"Hypokalemia"},{"rate":"3-5","effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL1581","moleculeType":"Small molecule","molecularWeight":"368.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Perindopril is an ACE inhibitor that prevents conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone secretion. Amlodipine is a calcium channel blocker that causes vasodilation by blocking calcium influx into vascular smooth muscle cells. Hydrochlorothiazide is a thiazide diuretic that reduces blood volume and sodium reabsorption in the distal convoluted tubule. Together, these agents provide complementary antihypertensive effects.","oneSentence":"This combination reduces blood pressure by blocking angiotensin II formation (perindopril), relaxing blood vessel smooth muscle (amlodipine), and reducing fluid volume (hydrochlorothiazide).","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:41:06.146Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension (essential hypertension in patients not adequately controlled on dual therapy)"}]},"trialDetails":[{"nctId":"NCT01101009","phase":"PHASE4","title":"Comparison of Sevikar® and the Combination of Perindopril/Amlodipine on Central Blood Pressure","status":"COMPLETED","sponsor":"Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company","startDate":"2010-04","conditions":"Hypertension","enrollment":486}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Perindopril + amlodipine + if necessary, hydrochlorothiazide","genericName":"Perindopril + amlodipine + if necessary, hydrochlorothiazide","companyName":"Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company","companyId":"daiichi-sankyo-europe-gmbh-a-daiichi-sankyo-company","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces blood pressure by blocking angiotensin II formation (perindopril), relaxing blood vessel smooth muscle (amlodipine), and reducing fluid volume (hydrochlorothiazide). Used for Hypertension (essential hypertension in patients not adequately controlled on dual therapy).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}