{"id":"perhyal-rinse","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth bleaching or discoloration"},{"rate":null,"effect":"Oral irritation or sensitivity"},{"rate":null,"effect":"Temporary gum tenderness"}]},"_chembl":null,"modality":"Small molecule","_dailymed":null,"mechanism":{"target":"Bacterial cell membranes","_ai_source":"claude-haiku-4.5","explanation":"Perhyal rinse acts as a topical antiseptic that disrupts the integrity of bacterial cell membranes, leading to bacterial cell death. It specifically targets anaerobic microorganisms commonly found in the oral cavity that contribute to periodontal disease and oral infections.","oneSentence":"Disrupts bacterial cell membranes and inhibits anaerobic microorganisms in the oral cavity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:49:17.021Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"_claudeStub":{"ts":1779138971,"model":"claude-sonnet-4-5-20250929"},"competitors":[{"name":"chlorhexidine gluconate","brand":"Peridex","company":"3M","rationale":"Gold standard antiseptic oral rinse for periodontal disease"},{"name":"cetylpyridinium chloride","brand":"Cepacol","company":null,"rationale":"Antiseptic mouthwash targeting oral bacteria"},{"name":"povidone-iodine","brand":"Betadine","company":"Avrio Health","rationale":"Broad-spectrum antiseptic used in oral care"}],"description":"Perhyal rinse is a topical antiseptic oral rinse in Phase 3 development by the University of Baghdad for dental and oral health applications. It targets bacterial cell membranes and anaerobic microorganisms in the oral cavity to reduce infection and promote oral hygiene.","indications":{"approved":[{"status":"investigational","condition":"Periodontal disease","patientPopulation":"Adult"},{"status":"investigational","condition":"Oral bacterial infections","patientPopulation":"Adult"}]},"trialDetails":[{"nctId":"NCT07031388","phase":"NA","title":"Mouthwashes for Gingivitis: Comparing a Hydrogen Peroxide-Hyaluronic Acid Mix, Hyaluronic Acid, and Chlorhexidine, A Triple-Blind Clinical Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ramziyah Hayder Bakr","startDate":"2025-07-01","conditions":"Plaque Induced Gingival Disease","enrollment":80},{"nctId":"NCT05787600","phase":"PHASE3","title":"Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide","status":"COMPLETED","sponsor":"University of Baghdad","startDate":"2023-03-03","conditions":"Plaque Induced Gingivitis, Mouth Diseases, Bleeding Gum","enrollment":54}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8291,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["BMG0703"],"phase":"phase_3","status":"active","brandName":"Perhyal rinse","genericName":"Perhyal rinse","companyName":"University of Baghdad","companyId":"university-of-baghdad","firstApprovalDate":"","aiSummary":"Perhyal rinse is a hydrogen peroxide-based oral rinse that works through oxidative antimicrobial action to disinfect and cleanse oral tissues. Used for Oral antisepsis and wound cleansing, Gingivitis and periodontal disease management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}