{"id":"perfosfamide","rwe":[{"pmid":"17101825","year":"2006","title":"Inhibition by mitoxantrone of in vitro migration of immunocompetent cells: a possible mechanism for therapeutic efficacy in the treatment of multiple sclerosis.","finding":"","journal":"Archives of neurology","studyType":"Clinical Study"},{"pmid":"9834301","year":"1998","title":"Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission.","finding":"","journal":"The New England journal of medicine","studyType":"Clinical Study"},{"pmid":"9815561","year":"1997","title":"Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.","finding":"","journal":"Clinical cancer research : an official journal of the American Association for Cancer Research","studyType":"Clinical Study"},{"pmid":"9514047","year":"1998","title":"The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair-deficient tumour cells.","finding":"","journal":"British journal of cancer","studyType":"Clinical Study"}],"tags":[{"label":"perfosfamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"hydroperoxycyclofosfamide","offLabel":[],"synonyms":["perfosfamide","hydroperoxycyclofosfamide"],"timeline":[],"approvals":[],"brandName":"Hydroperoxycyclofosfamide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"perfosfamide","explanation":"Imagine your DNA as a blueprint for your cells. Hydroperoxycyclofosfamide disrupts this blueprint by creating crosslinks, making it difficult for cells to function and ultimately leading to cell death. This process is a key mechanism by which perfosfamide exerts its effects.","oneSentence":"Hydroperoxycyclofosfamide works by inducing DNA crosslinks, which ultimately leads to cell death.","technicalDetail":"Hydroperoxycyclofosfamide induces DNA crosslinks through the formation of platinum-DNA adducts, which interfere with DNA replication and transcription, ultimately leading to cell death through apoptosis or necrosis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3430","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PERFOSFAMIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PERFOSFAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:17:13.083398","biosimilars":[],"competitors":[],"genericName":"perfosfamide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02446431","phase":"EARLY_PHASE1","title":"Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence","status":"RECRUITING","sponsor":"Miller Children's & Women's Hospital Long Beach","startDate":"2014-07","conditions":["Solid Tumor"],"enrollment":20,"completionDate":"2029-07"},{"nctId":"NCT00002634","phase":"PHASE2","title":"Chemotherapy, Radiation Therapy, Immunotherapy, and Bone Marrow Transplantation in Treating Patients With Neuroblastoma","status":"COMPLETED","sponsor":"Memorial Sloan Kettering Cancer Center","startDate":"1995-02","conditions":["Neuroblastoma"],"enrollment":45,"completionDate":"2004-09"},{"nctId":"NCT00002552","phase":"PHASE2","title":"Chemotherapy Plus Bone Marrow Transplantation in Treating Patients With Refractory Non-Hodgkin's Lymphoma, Hodgkin's Disease, or Multiple Myeloma","status":"COMPLETED","sponsor":"Barbara Ann Karmanos Cancer Institute","startDate":"1993-10","conditions":["Lymphoma","Multiple Myeloma and Plasma Cell Neoplasm"],"enrollment":40,"completionDate":"2003-10"},{"nctId":"NCT00556764","phase":"EARLY_PHASE1","title":"Development of Cognitive Assessment Tools in Parkinson Disease","status":"COMPLETED","sponsor":"Institute for Neurodegenerative Disorders","startDate":"2007-07","conditions":["Parkinson Disease"],"enrollment":75,"completionDate":"2011-03"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"U880A4FUDA","CHEBI":"CHEBI:135223","INN_ID":"6687","UMLSCUI":"C0163054","ChEMBL_ID":"CHEMBL61511","KEGG_DRUG":"D05441","DRUGBANK_ID":"DB12727","PUBCHEM_CID":"38347","MESH_SUPPLEMENTAL_RECORD_UI":"C011272"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2006 Nov","pmid":"17101825","title":"Inhibition by mitoxantrone of in vitro migration of immunocompetent cells: a possible mechanism for therapeutic efficacy in the treatment of multiple sclerosis.","journal":"Archives of neurology"},{"date":"1998 Dec 3","pmid":"9834301","title":"Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission.","journal":"The New England journal of medicine"},{"date":"1997 Oct","pmid":"9815561","title":"Resistance to cytotoxic drugs in DNA mismatch repair-deficient cells.","journal":"Clinical cancer research : an official journal of the American Association for Cancer Research"},{"date":"1998 Mar","pmid":"9514047","title":"The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair-deficient tumour cells.","journal":"British journal of cancer"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hydroperoxycyclofosfamide is a small molecule with the synonyms 4-HC, 4-HYDROPEROXYCYCLOPHOSPHAMIDE, NSC-181815, PERFOSFAMIDA, PERFOSFAMIDE, and PERFOSFAMIDE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}