{"id":"perflutren-lipid-microspheres","safety":{"commonSideEffects":[{"rate":"null","effect":"Hypersensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"They work by encapsulating perflutren, a gas that is highly reflective of ultrasound waves, within lipid microspheres. When injected into the bloodstream, these microspheres accumulate in the left ventricle and are then cleared by the liver, allowing for improved visualization of cardiac structures and function.","oneSentence":"Perflutren lipid microspheres are ultrasound contrast agents that enhance the visibility of blood flow and cardiac function during echocardiography.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:49:11.018Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contrast enhancement for echocardiography"}]},"trialDetails":[{"nctId":"NCT07436364","phase":"EARLY_PHASE1","title":"Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy","status":"NOT_YET_RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2026-03","conditions":"Soft Tissue Sarcoma","enrollment":10},{"nctId":"NCT04715958","phase":"PHASE2, PHASE3","title":"Prediction of Neoadjuvant Chemotherapy Response Using Contrast-Enhanced Ultrasound in Patients With Locally Advanced Breast Cancer","status":"RECRUITING","sponsor":"Kibo Nam","startDate":"2020-12-07","conditions":"Anatomic Stage III Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma","enrollment":200},{"nctId":"NCT06171607","phase":"PHASE1","title":"Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses","status":"RECRUITING","sponsor":"University of Southern California","startDate":"2020-11-05","conditions":"Breast Carcinoma","enrollment":100},{"nctId":"NCT07335315","phase":"","title":"Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2024-06-19","conditions":"Pituitary Adenoma, Cushing Disease","enrollment":110},{"nctId":"NCT07314385","phase":"PHASE1","title":"NH002-mediated Sonoporation With Chemotherapy in Advanced Pancreatic Cancer","status":"NOT_YET_RECRUITING","sponsor":"National Taiwan University Hospital","startDate":"2026-01-01","conditions":"Pancreatic Adenocarcinoma Metastatic, Liver Metastasis","enrollment":24},{"nctId":"NCT06797193","phase":"NA","title":"Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2025-03-13","conditions":"Portal Hypertension","enrollment":60},{"nctId":"NCT06024772","phase":"PHASE3","title":"Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer","status":"NOT_YET_RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2026-03-15","conditions":"Prostate Carcinoma","enrollment":300},{"nctId":"NCT04185246","phase":"PHASE1, PHASE2","title":"A Dose Ascending Study to Evaluate the Safety of NH002 as a Contrast Agent in Cardiac Echocardiography","status":"COMPLETED","sponsor":"Trust Bio-sonics, Inc.","startDate":"2019-11-04","conditions":"Cardiac Disease","enrollment":36},{"nctId":"NCT05090800","phase":"PHASE2","title":"Contrast Enhanced Ultrasound for Renal Obstruction","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2021-12-03","conditions":"Kidney; Obstruction, Renal Obstruction","enrollment":10},{"nctId":"NCT07193953","phase":"PHASE1","title":"Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS)","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2025-04-15","conditions":"Amyotrophic Lateral Sclerosis, ALS","enrollment":6},{"nctId":"NCT07179328","phase":"PHASE1","title":"Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy","status":"RECRUITING","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2025-06-04","conditions":"GBM, Glioblastoma Multiforme (GBM), Glioblastoma Multiforme of Brain","enrollment":10},{"nctId":"NCT05764642","phase":"PHASE2","title":"A Study of Renal Microvessel Imaging for Chronic Kidney Disease","status":"ENROLLING_BY_INVITATION","sponsor":"Mayo Clinic","startDate":"2023-08-09","conditions":"Healthy, Chronic Kidney Diseases","enrollment":186},{"nctId":"NCT05336786","phase":"PHASE3","title":"Prostate Cancer Diagnosis by Multiparametric Ultrasound (Wholemount)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Thomas Jefferson University","startDate":"2022-06-15","conditions":"Prostate Carcinoma","enrollment":70},{"nctId":"NCT06571786","phase":"PHASE2","title":"SHAPE for ICP Assessment","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2024-12-15","conditions":"Lumbar Puncture","enrollment":19},{"nctId":"NCT05530798","phase":"NA","title":"CEUS For Intraoperative Spinal Cord Injury","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2023-12-01","conditions":"Spine Disease, Spinal Stenosis, Spinal Injury","enrollment":20},{"nctId":"NCT06815627","phase":"PHASE3","title":"Safety and Efficacy Evaluation of NH002 as a Contrast Agent in Subjects Undergoing Cardiac Echocardiography","status":"RECRUITING","sponsor":"Trust Bio-sonics, Inc.","startDate":"2025-03-18","conditions":"Cardiac Diseases","enrollment":150},{"nctId":"NCT01122069","phase":"","title":"Contrast Echocardiography in Non-ST Elevation Myocardial Infarction","status":"COMPLETED","sponsor":"University of Bergen","startDate":"2008-03","conditions":"Non-ST-Elevation Myocardial Infarction","enrollment":110},{"nctId":"NCT03297112","phase":"EARLY_PHASE1","title":"Contrast-Enhanced Subharmonic Ultrasound Imaging in Improving Characterization of Adnexal Masses in Patients Undergoing Surgery","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2017-08-01","conditions":"Adnexal Mass","enrollment":12},{"nctId":"NCT02115607","phase":"NA","title":"Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2014-03","conditions":"Breast Cancer","enrollment":17},{"nctId":"NCT03045497","phase":"PHASE1","title":"Contrast-Enhanced Ultrasound in Predicting Treatment Response in Patients With Liver Cancer Receiving Transarterial Chemoembolization With Drug Eluting Beads","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University","startDate":"2012-12-12","conditions":"Hepatocellular Carcinoma","enrollment":15},{"nctId":"NCT02967458","phase":"PHASE2","title":"Detection of High Grade Prostate Cancer With Subharmonic Ultrasound Imaging, A Pilot Study","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2017-02-01","conditions":"Prostatic Neoplasm","enrollment":55},{"nctId":"NCT05416385","phase":"","title":"Carotid Intraplaque Neovascularization Combined With Stress Echo","status":"RECRUITING","sponsor":"Dr. Amer Johri","startDate":"2021-08-16","conditions":"Atherosclerosis, Cardiovascular Diseases, Acute Coronary Syndrome","enrollment":1500},{"nctId":"NCT02950493","phase":"NA","title":"Use of Reactivated DEFINITY or LUMASON in Patients Undergoing Rest or Stress Echocardiography","status":"TERMINATED","sponsor":"University of Nebraska","startDate":"2017-04-06","conditions":"Stress Echocardiography","enrollment":20},{"nctId":"NCT04118764","phase":"NA","title":"Non-invasive Blood-brain Barrier Opening in Alzheimer's Disease Patients Using Focused Ultrasound","status":"COMPLETED","sponsor":"Columbia University","startDate":"2020-08-06","conditions":"Alzheimer Disease","enrollment":6},{"nctId":"NCT05613946","phase":"PHASE1","title":"Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2022-12-15","conditions":"Lymphedema Arm","enrollment":10},{"nctId":"NCT04056988","phase":"PHASE4","title":"tSCI Contrast Enhanced Ultrasound Study","status":"COMPLETED","sponsor":"University of Washington","startDate":"2018-07-31","conditions":"Acute Spinal Cord Injury","enrollment":9},{"nctId":"NCT03907657","phase":"PHASE2","title":"Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2019-09-23","conditions":"Von-Hippel Lindau, Kidney Disease, Chronic","enrollment":15},{"nctId":"NCT02384473","phase":"EARLY_PHASE1","title":"Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma","status":"COMPLETED","sponsor":"University of Southern California","startDate":"2014-12-24","conditions":"Adult Soft Tissue Sarcoma, Bone Sarcoma, Retroperitoneal Sarcoma","enrollment":25},{"nctId":"NCT04021238","phase":"PHASE2","title":"Contrast-Enhanced Ultrasound for Kidney Cancer Subtyping and Staging","status":"COMPLETED","sponsor":"UNC Lineberger Comprehensive Cancer Center","startDate":"2020-10-07","conditions":"Kidney Cancer","enrollment":25},{"nctId":"NCT02170103","phase":"NA","title":"Microvascular Recovery With Ultrasound in Myocardial Infarction (MRUSMI) Post PCI Trial","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2018-09-16","conditions":"STEMI, Chest Pain","enrollment":50},{"nctId":"NCT00575549","phase":"","title":"Prospective Analysis and Comparison of Stress Echo to Real-Time Myocardial Contrast Stress Echo","status":"NO_LONGER_AVAILABLE","sponsor":"University of Nebraska","startDate":"","conditions":"Evaluation of Troponin I Levels","enrollment":""},{"nctId":"NCT02424955","phase":"NA","title":"Feasibility 3D Perfusion Ultrasound for Liver Cancer SABR Planning and Response Evaluation","status":"COMPLETED","sponsor":"Stanford University","startDate":"2014-11-18","conditions":"Liver Cancer, Liver Tumor, Hepatocellular Carcinoma","enrollment":11},{"nctId":"NCT02102243","phase":"PHASE4","title":"Neural Mechanism of Aldosterone-induced Insulin Resistance","status":"WITHDRAWN","sponsor":"Wanpen Vongpatanasin","startDate":"2010-11","conditions":"Hypertension","enrollment":""},{"nctId":"NCT01631318","phase":"NA","title":"Pilot 3D Contrast-Enhanced Ultrasound Imaging to Predict Treatment Response in Liver Metastases","status":"COMPLETED","sponsor":"Stanford University","startDate":"2012-11-01","conditions":"Liver Metastases, Colon Cancer","enrollment":34},{"nctId":"NCT01141816","phase":"NA","title":"Contrast-enhanced Ultrasound for Follow-up After Radiofrequency Ablation of Kidney Lesions","status":"UNKNOWN","sponsor":"St. Joseph's Healthcare Hamilton","startDate":"2015-01","conditions":"Carcinoma, Renal Cell","enrollment":30},{"nctId":"NCT03196076","phase":"PHASE2","title":"Contrast-enhanced Ultrasound for Complex Kidney Lesion Diagnosis in Patients With CKD Extension","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2017-08-28","conditions":"Chronic Kidney Diseases, Cystic Kidney Disease","enrollment":25},{"nctId":"NCT03092089","phase":"PHASE2","title":"Sonothrombolysis in Patients With STEMI","status":"COMPLETED","sponsor":"Harald Becher","startDate":"2017-08-15","conditions":"ST-segment Elevation Myocardial Infarction","enrollment":15},{"nctId":"NCT00162370","phase":"PHASE4","title":"A Study of Stress Echocardiography in Post-Menopausal Women at Risk for Coronary Disease","status":"COMPLETED","sponsor":"Lantheus Medical Imaging","startDate":"2004-04","conditions":"Coronary Artery Disease, Heart Disease","enrollment":400},{"nctId":"NCT00918866","phase":"PHASE4","title":"A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure","status":"COMPLETED","sponsor":"Lantheus Medical Imaging","startDate":"2009-07","conditions":"Pulmonary Heart Disease","enrollment":32},{"nctId":"NCT00625365","phase":"PHASE4","title":"A Prospective, Phase IV, Surveillance Registry Study to Evaluate the Safety of DEFINITY® in Clinical Practice","status":"COMPLETED","sponsor":"Lantheus Medical Imaging","startDate":"2008-02","conditions":"Cardiovascular Disease","enrollment":1060},{"nctId":"NCT02684435","phase":"PHASE2","title":"Contrast-enhanced Ultrasound of the Kidney","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2016-02","conditions":"Chronic Kidney Disease, Cystic Kidney Disease","enrollment":63},{"nctId":"NCT02880137","phase":"PHASE4","title":"Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2016-09","conditions":"Cardiac Allograft Vasculopathy","enrollment":36},{"nctId":"NCT03212326","phase":"NA","title":"Contrast ICE for Myocardial Scar in VT Ablations","status":"COMPLETED","sponsor":"Weill Medical College of Cornell University","startDate":"2013-03","conditions":"Ventricular Tachycardia, Ischemic Cardiomyopathy","enrollment":24},{"nctId":"NCT03300401","phase":"NA","title":"Contrast-Enhanced Ultrasound in Diagnosing Patients With Liver Cancer Undergoing Yttrium-90 Radioembolization","status":"WITHDRAWN","sponsor":"University of Southern California","startDate":"2017-11-07","conditions":"Hepatocellular Carcinoma","enrollment":""},{"nctId":"NCT02067884","phase":"PHASE1","title":"Contrast Enhanced Ultrasound and Shear Wave Elastography in Measuring Response in Patients With Breast Cancer Receiving Chemotherapy Before Surgery","status":"TERMINATED","sponsor":"University of Southern California","startDate":"2013-12-19","conditions":"Breast Cancer","enrollment":34},{"nctId":"NCT01242020","phase":"NA","title":"Microvascular Flow Assessment Repeatability Study: The MARS Study","status":"TERMINATED","sponsor":"University of Pennsylvania","startDate":"2011-01","conditions":"Obesity","enrollment":6},{"nctId":"NCT00584402","phase":"NA","title":"Contrast Sonography for Evaluation of Liver Tumors Prior to Radiofrequency Ablation","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2007-04","conditions":"Liver Neoplasms","enrollment":8},{"nctId":"NCT00626873","phase":"PHASE1","title":"Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2007-01","conditions":"Ovarian Cancer","enrollment":67},{"nctId":"NCT01391039","phase":"NA","title":"Diagnostic Study of Early Breast Cancer Using Ultrasound","status":"TERMINATED","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2011-09","conditions":"Ductal Carcinoma In-situ","enrollment":12},{"nctId":"NCT01021865","phase":"","title":"Effects of Hyperglycemia on Myocardial Perfusion in Humans With and Without Type 2 Diabetes","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2010-02","conditions":"Coronary Artery Disease, Diabetes Mellitus Type 2","enrollment":33},{"nctId":"NCT00239525","phase":"NA","title":"3-D Transcranial Ultrasound Analysis Study","status":"COMPLETED","sponsor":"Duke University","startDate":"2006-05","conditions":"Cerebrovascular Accident, Intracranial Hypertension","enrollment":28},{"nctId":"NCT00162058","phase":"PHASE2","title":"A Phase II Study of DMP 115 to Assess Focal Liver Lesions","status":"COMPLETED","sponsor":"Lantheus Medical Imaging","startDate":"2004-03","conditions":"Liver Disease","enrollment":80},{"nctId":"NCT00401687","phase":"PHASE4","title":"DMP115 in Patients With an Ejection Fraction Between 25%-40% to Evaluate the Use of Contrast Echocardiography to Assess Heart Function","status":"COMPLETED","sponsor":"Lantheus Medical Imaging","startDate":"2006-07","conditions":"Ventricular Ejection Fraction","enrollment":131},{"nctId":"NCT00631553","phase":"NA","title":"Assessment of Changes in Renal Cortical and Medullary Blood Flow by Contrast Ultrasound","status":"UNKNOWN","sponsor":"University of Virginia","startDate":"2006-06","conditions":"Kidney","enrollment":20},{"nctId":"NCT00507806","phase":"PHASE1, PHASE2","title":"Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke","status":"TERMINATED","sponsor":"ImaRx Therapeutics","startDate":"2005-03","conditions":"Acute Ischemic Stroke","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":22,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Definity"],"phase":"phase_3","status":"active","brandName":"perflutren lipid microspheres","genericName":"perflutren lipid microspheres","companyName":"University of Virginia","companyId":"university-of-virginia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Perflutren lipid microspheres are a small molecule diagnostic agent used in ultrasound imaging. They have been studied in various clinical trials for conditions such as stress echocardiography, kidney obstruction, and liver neoplasms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}