{"id":"peppermint-sweets","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral irritation or burning sensation (in sensitive individuals)"},{"rate":null,"effect":"Allergic reaction to peppermint (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Menthol, the active compound in peppermint, binds to transient receptor potential melastatin 8 (TRPM8) channels, creating a cooling sensation that can help soothe minor throat irritation and provide temporary symptomatic relief. The mechanism is primarily sensory rather than pharmacological, making peppermint sweets a consumer health product rather than a traditional pharmaceutical agent.","oneSentence":"Peppermint sweets provide symptomatic relief through the cooling and soothing properties of menthol, which activates TRPM8 receptors to produce a refreshing sensation in the oral cavity and throat.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:49:09.031Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Symptomatic relief of minor throat irritation and cough"}]},"trialDetails":[{"nctId":"NCT07326163","phase":"NA","title":"The Effect of Peppermint Oil Aromatherapy on Pain, Functional Capacity and Cost in Fibromyalgia Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Bilecik Seyh Edebali Universitesi","startDate":"2026-03-01","conditions":"Fibromyalgia, Aromatherapy, Cost","enrollment":175},{"nctId":"NCT07318779","phase":"NA","title":"Effect of Cardamom and Peppermint Oils on Chemotherapy-Related Nausea-Vomiting and Food Intake","status":"NOT_YET_RECRUITING","sponsor":"Semanur Bilgiç","startDate":"2026-01-01","conditions":"Cancer","enrollment":39},{"nctId":"NCT05799053","phase":"PHASE3","title":"Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2022-05-12","conditions":"Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Child","enrollment":228},{"nctId":"NCT04800744","phase":"NA","title":"Aromatherapy for Improving Post-Surgical Quality of Life","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2021-03-22","conditions":"Quality of Life, Anxiety Postoperative","enrollment":70},{"nctId":"NCT04118322","phase":"NA","title":"The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy","status":"COMPLETED","sponsor":"TC Erciyes University","startDate":"2017-09-10","conditions":"Chemotherapy Effect, Adverse Effect, Nursing Caries","enrollment":90},{"nctId":"NCT03738657","phase":"","title":"Gustatory Function Following Radiotherapy to the Head and Neck","status":"UNKNOWN","sponsor":"Royal Marsden NHS Foundation Trust","startDate":"2018-08-29","conditions":"Head and Neck Cancer","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Wilhelmina®"],"phase":"phase_3","status":"active","brandName":"Peppermint sweets","genericName":"Peppermint sweets","companyName":"St. Antonius Hospital","companyId":"st-antonius-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Peppermint sweets provide symptomatic relief through the cooling and soothing properties of menthol, which activates TRPM8 receptors to produce a refreshing sensation in the oral cavity and throat. Used for Symptomatic relief of minor throat irritation and cough.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}