{"id":"peppermint","rwe":[{"pmid":"41912996","year":"2026","title":"Pseudomonas fluorescens improves morph-physiological characteristics, essential oil compounds, and gene expression implicated in menthol biosynthesis under water stress conditions in peppermint.","finding":"","journal":"Antonie van Leeuwenhoek","studyType":"Clinical Study"},{"pmid":"41881284","year":"2026","title":"Nose-to-Brain delivery of genistein-loaded peppermint lipid nanocapsules for neuroprotection against Alzheimer's Disease: Formulation, Characterization, pharmacokinetic and Pharmacodynamic studies.","finding":"","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","studyType":"Clinical Study"},{"pmid":"41871816","year":"2026","title":"Synergistic anti-Candida effects of essential oil blends on biofilms at various maturation stages.","finding":"","journal":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","studyType":"Clinical Study"},{"pmid":"41866875","year":"2025","title":"Expert Opinion on the Efficacy and Safety of Antispasmodics with a Focus on Irritable Bowel Syndrome.","finding":"","journal":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology","studyType":"Clinical Study"},{"pmid":"41865907","year":"2026","title":"Impacts of flavor and aromatic palatants on consumption behavior in nursing foals.","finding":"","journal":"Journal of equine veterinary science","studyType":"Clinical Study"}],"_fda":{"id":"42c4b70c-deb0-84c1-e063-6394a90ac951","set_id":"07aa98b3-699a-bf8d-e063-6294a90a2dee","openfda":{"unii":["H0G9379FGK"],"route":["ORAL"],"rxcui":["308892"],"spl_id":["42c4b70c-deb0-84c1-e063-6394a90ac951"],"brand_name":["Ultra Strength Antacid"],"spl_set_id":["07aa98b3-699a-bf8d-e063-6294a90a2dee"],"package_ndc":["11673-786-66","11673-776-66"],"product_ndc":["11673-776","11673-786"],"generic_name":["CALCIUM CARBONATE PEPPERMINT","CALCIUM CARBONATE ASSORTED BERRIES"],"product_type":["HUMAN OTC DRUG"],"substance_name":["CALCIUM CARBONATE"],"manufacturer_name":["TARGET CORPORATION"],"application_number":["M001"],"is_original_packager":[true]},"purpose":["Purpose Antacid"],"version":"4","warnings":["Ask a doctor or pharmacist before use if you are presently taking a prescription drug. Antacids may interact with certain prescription drugs."],"questions":["Questions or comments? Call 1-800-910-6874"],"when_using":["When using this product do not take more than 7 tablets in 24 hours if pregnant, do not take more than 5 tablets in 24 hours do not use the maximum dosage for more than 2 weeks except under the advice and supervision of a doctor."],"effective_time":"20251104","active_ingredient":["Active ingredient (per tablet) Calcium Carbonate USP 1000 mg"],"inactive_ingredient":["Calcium Carbonate 1000 mg Chewable Tablets - Assorted Fruit (Ultra Strength) Inactive ingredients adipic acid, corn starch, D&C red 27 Al lake, D&C yellow 10 Al lake, dextrose anhydrous, FD&C blue no. 1 Al lake, FD&C yellow #6 Al lake, flavor, magnesium stearate, maltodextrin, sucralose Calcium Carbonate 1000 mg Chewable Tablets - Peppermint (Ultra Strength) Inactive ingredients adipic acid, corn starch, dextrose anhydrous, flavor, magnesium stearate, maltodextrin, sucralose"],"indications_and_usage":["Uses relieves Heartburn Sour stomach Acid indigestion Upset stomach associated with these symptoms"],"other_safety_information":["Other information each tablet contains: elemental calcium 400 mg store at room temperature. Keep the container tightly closed"],"spl_unclassified_section":["Drug Facts"],"dosage_and_administration":["Directions Adults and children 12 years of age and over: chew and swallow 2-3 tablets as symptoms occur, or as directed by a doctor. Do not take for symptoms that persist for more than 2 weeks unless advised by a doctor."],"spl_product_data_elements":["Ultra Strength Antacid Calcium Carbonate Assorted berries D&C RED NO. 27 ALUMINUM LAKE ADIPIC ACID MAGNESIUM STEARATE ANHYDROUS DEXTROSE FD&C BLUE NO. 1 ALUMINUM LAKE SUCRALOSE STARCH, CORN D&C YELLOW NO. 10 ALUMINUM LAKE FD&C YELLOW NO. 6 ALUMINUM LAKE CALCIUM CARBONATE CARBONATE ION CALCIUM CATION MALTODEXTRIN , Pink, Green, Yellow T472 Assorted fruit (Lemon, Lime Marvel, Orange, Strawberry) Ultra Strength Antacid Calcium Carbonate Peppermint ADIPIC ACID MAGNESIUM STEARATE CALCIUM CARBONATE CARBONATE ION CALCIUM CATION STARCH, CORN MALTODEXTRIN ANHYDROUS DEXTROSE SUCRALOSE Mottled white color T472"],"keep_out_of_reach_of_children":["Keep out of reach of children."],"package_label_principal_display_panel":["905R_label 908R_Calcium carbonate 1000mg-Peppermint"]},"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Oral","category":"route"},{"label":"Active","category":"status"},{"label":"Heartburn","category":"indication"},{"label":"Sour stomach","category":"indication"},{"label":"Acid indigestion","category":"indication"},{"label":"Upset stomach","category":"indication"},{"label":"Target Corporation","category":"company"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"127 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"112 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"106 reports"},{"date":"","signal":"DYSPNOEA","source":"FDA FAERS","actionTaken":"90 reports"},{"date":"","signal":"DIZZINESS","source":"FDA FAERS","actionTaken":"83 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"77 reports"},{"date":"","signal":"MALAISE","source":"FDA FAERS","actionTaken":"63 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"59 reports"},{"date":"","signal":"CONSTIPATION","source":"FDA FAERS","actionTaken":"55 reports"},{"date":"","signal":"VOMITING","source":"FDA FAERS","actionTaken":"53 reports"}]},"trials":[],"aliases":[],"company":"Target Corporation","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=PEPPERMINT","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:33:48.968291+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:33:54.405115+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PEPPERMINT","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:33:54.996713+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:33:47.788824+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:33:47.788854+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T03:33:56.655622+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2108758/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:33:55.709310+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M001","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:33:47.788859+00:00"}},"allNames":"ultra strength antacid","offLabel":[],"synonyms":["Ultra Strength Antacid","CALCIUM CARBONATE"],"timeline":[],"approvals":[],"brandName":"Ultra Strength Antacid","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"Ultra Strength Antacid contains an antacid component that rapidly neutralizes gastric acid, providing quick relief from symptoms of heartburn, sour stomach, acid indigestion, and upset stomach."},"commercial":{},"references":[{"id":1,"url":"https://api.fda.gov/drug/label.json?search=openfda.generic_name:\"PEPPERMINT\"","fields":["mechanism","indications","adverse_reactions","contraindications","warnings","dosage"],"source":"OpenFDA Label"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=peppermint","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=peppermint","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-31T10:37:52.798649","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:33:58.218573+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"peppermint","indications":{"approved":[{"name":"Heartburn","source":"OpenFDA Label","regulator":"FDA","eligibility":"Adults and children 5 years and older"},{"name":"Sour stomach","source":"OpenFDA Label","regulator":"FDA","eligibility":"Adults and children 5 years and older"},{"name":"Acid indigestion","source":"OpenFDA Label","regulator":"FDA","eligibility":"Adults and children 5 years and older"},{"name":"Upset stomach","source":"OpenFDA Label","regulator":"FDA","eligibility":"Adults and children 5 years and older"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07240246","phase":"NA","title":"Effect of a Dietary Supplement on Hormones Involved in Appetite Regulation in Overweight and Obese Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"FFoQSI - Austrian Competence Centre for Feed and Food Quality, Safety & Innovation","startDate":"2025-10-24","conditions":["GLP-1","Obesity &Amp; Overweight","Dietary Supplement"],"enrollment":40,"completionDate":"2026-05-11"},{"nctId":"NCT07493434","phase":"NA","title":"Evaluation of Pain Thresholds in Migraine Patients After Inhalation of Essential Oils: a Randomized Clinical Trial","status":"ENROLLING_BY_INVITATION","sponsor":"University of Sao Paulo","startDate":"2025-03-13","conditions":["Migraine"],"enrollment":200,"completionDate":"2027-03"},{"nctId":"NCT07221123","phase":"EARLY_PHASE1","title":"Boosting Olfactory and Sensory Training Study (BOOST)","status":"NOT_YET_RECRUITING","sponsor":"University of Alabama at Birmingham","startDate":"2026-05-01","conditions":["HIV (Human Immunodeficiency Virus)"],"enrollment":80,"completionDate":"2027-12-31"},{"nctId":"NCT07326163","phase":"NA","title":"The Effect of Peppermint Oil Aromatherapy on Pain, Functional Capacity and Cost in Fibromyalgia Patients","status":"ENROLLING_BY_INVITATION","sponsor":"Bilecik Seyh Edebali Universitesi","startDate":"2026-03-01","conditions":["Fibromyalgia","Aromatherapy","Cost"],"enrollment":175,"completionDate":"2027-01-01"},{"nctId":"NCT03319498","phase":"NA","title":"Postpartum Urinary Retention With Essential Oils (PURE)","status":"TERMINATED","sponsor":"Mount Carmel Health System","startDate":"2018-01-01","conditions":["Urinary Retention"],"enrollment":77,"completionDate":"2026-02-16"},{"nctId":"NCT04966546","phase":"EARLY_PHASE1","title":"Targeting Spreading Depolarization After Chronic Subdural Hematoma Surgery (TASD)","status":"WITHDRAWN","sponsor":"University of New Mexico","startDate":"2022-06-01","conditions":["Chronic Subdural Hematoma"],"enrollment":0,"completionDate":"2025-12-01"},{"nctId":"NCT04966507","phase":"PHASE2","title":"Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention","status":"COMPLETED","sponsor":"University of California, Los Angeles","startDate":"2022-02-17","conditions":["Gonorrhea"],"enrollment":89,"completionDate":"2025-12-12"},{"nctId":"NCT07382310","phase":"NA","title":"Effect of Different Products to Support Plaque Control During Daytime","status":"COMPLETED","sponsor":"King Abdullah University Hospital","startDate":"2020-09-18","conditions":["Dental Plaque","Dental Plaque Accumulation","Mouthwashes","Chewing Gum"],"enrollment":20,"completionDate":"2022-05-16"},{"nctId":"NCT07403604","phase":"PHASE1","title":"Effect of Insulin Lowering on Lipogenesis","status":"NOT_YET_RECRUITING","sponsor":"Columbia University","startDate":"2026-04","conditions":["Hyperinsulinemia","Insulin Resistance","Non-Alcoholic Fatty Liver Disease","Prediabetic State","Obesity"],"enrollment":25,"completionDate":"2029-06"},{"nctId":"NCT07386860","phase":"NA","title":"The Effectiveness of Steroid Nasal Drops in the Olfactory Cleft Combined With Olfactory Training for Patients With PIOD","status":"NOT_YET_RECRUITING","sponsor":"Peking University Third Hospital","startDate":"2026-03-01","conditions":["Smell Dysfunction"],"enrollment":100,"completionDate":"2028-12-31"},{"nctId":"NCT07370740","phase":"NA","title":"A Clinical Trial to Investigate the Safety and Efficacy of Bloat on Gas and Bloating in Healthy Women","status":"NOT_YET_RECRUITING","sponsor":"Arrae","startDate":"2026-05","conditions":["Bloating","Gastrointestinal Symptoms","Intestinal Gas"],"enrollment":100,"completionDate":"2026-07"},{"nctId":"NCT06296147","phase":"NA","title":"Virtual Reality Headset and/or Aromatherapy for Patients Undergoing a Transperineal Prostate Biopsy","status":"RECRUITING","sponsor":"University of Pittsburgh","startDate":"2024-05-20","conditions":["Prostate Cancer"],"enrollment":208,"completionDate":"2026-05-01"},{"nctId":"NCT05561543","phase":"NA","title":"Effects of Peppermint Oil in Mild-moderate Hypertension.","status":"COMPLETED","sponsor":"University of Central Lancashire","startDate":"2024-01-01","conditions":["Hypertension"],"enrollment":40,"completionDate":"2025-08-10"},{"nctId":"NCT07320781","phase":"NA","title":"Role of Preoperative Tapentadol in Reduction of Perioperative Analgesic Requirement After Breast Conservative Surgery in Cancer Patients.","status":"COMPLETED","sponsor":"Shaukat Khanum Memorial Cancer Hospital & Research Centre","startDate":"2024-11-15","conditions":["Breast Cancer"],"enrollment":70,"completionDate":"2025-10-10"},{"nctId":"NCT05644262","phase":"PHASE2","title":"Life's End Benefits of cannaBidiol and tetrahYdrocannabinol","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Southern California","startDate":"2023-12-18","conditions":["Agitation","Dementia"],"enrollment":120,"completionDate":"2026-03"},{"nctId":"NCT05729282","phase":"PHASE1","title":"Glycemic Effect of Diazoxide in NAFLD","status":"COMPLETED","sponsor":"Columbia University","startDate":"2023-08-01","conditions":["Hyperinsulinemia","Insulin Resistance","Non-Alcoholic Fatty Liver Disease","Prediabetic State"],"enrollment":24,"completionDate":"2025-09-10"},{"nctId":"NCT07318779","phase":"NA","title":"Effect of Cardamom and Peppermint Oils on Chemotherapy-Related Nausea-Vomiting and Food Intake","status":"NOT_YET_RECRUITING","sponsor":"Semanur Bilgiç","startDate":"2026-01-01","conditions":["Cancer"],"enrollment":39,"completionDate":"2026-11-01"},{"nctId":"NCT07111234","phase":"NA","title":"Studying Flavors and Cooling Agents in Oral Nicotine Pouches to Understand User Preferences","status":"RECRUITING","sponsor":"Ohio State University Comprehensive Cancer Center","startDate":"2025-09-15","conditions":["Cigarette Smoking-Related Carcinoma"],"enrollment":30,"completionDate":"2026-12-31"},{"nctId":"NCT07127523","phase":"NA","title":"A Clinical Trial to Investigate the Efficacy and Safety of GenLabs' Social Skin on Improving Acne Symptoms and Skin Repair Among Healthy Adults","status":"NOT_YET_RECRUITING","sponsor":"GenCanna Acquisition Corp","startDate":"2026-01","conditions":["Acne"],"enrollment":150,"completionDate":"2026-04"},{"nctId":"NCT07201883","phase":"PHASE1","title":"Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients","status":"ACTIVE_NOT_RECRUITING","sponsor":"Makassed General Hospital","startDate":"2025-08-22","conditions":["Postoperative Nausea and Vomiting (PONV)"],"enrollment":90,"completionDate":"2026-02-28"},{"nctId":"NCT07198243","phase":"PHASE4","title":"The Effects of STW 5-II on Duodenal Mucosa and Symptoms in Functional Dyspepsia","status":"NOT_YET_RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2025-09-30","conditions":["Functional Dyspepsia"],"enrollment":100,"completionDate":"2028-12-01"},{"nctId":"NCT07179094","phase":"NA","title":"The Effect of a Protective Oral Care Protocol Using Peppermint Oil Mouthwash","status":"NOT_YET_RECRUITING","sponsor":"Şule Güzle","startDate":"2025-09-10","conditions":["Hematologic Neoplasms","Nausea","Vomiting","Anorexia"],"enrollment":72,"completionDate":"2026-06-10"},{"nctId":"NCT05302583","phase":"NA","title":"Aromatherapy Inhaler Use for HSCT Distress","status":"RECRUITING","sponsor":"Stanford University","startDate":"2025-06-16","conditions":["Cancer Distress","Cancer Coping","Hematopoetic Stem Cell Transplant","Aromatherapy"],"enrollment":50,"completionDate":"2026-03"},{"nctId":"NCT05259800","phase":"NA","title":"Peppermint Oil for Urinary Retention","status":"TERMINATED","sponsor":"TriHealth Inc.","startDate":"2021-10-05","conditions":["Urinary Retention"],"enrollment":17,"completionDate":"2025-04-01"},{"nctId":"NCT07126301","phase":"NA","title":"Aromatherapy Essential Oils to Manage Anxiety and Nausea in Cancer Patients Receiving Infusion in the Ambulatory Setting","status":"RECRUITING","sponsor":"City of Hope Medical Center","startDate":"2025-07-08","conditions":["Hematopoietic and Lymphatic System Neoplasm","Malignant Solid Neoplasm"],"enrollment":60,"completionDate":"2027-01-01"},{"nctId":"NCT07060755","phase":"NA","title":"Effect of Different Foot Baths on Postpartum Insomnia and Fatigue","status":"NOT_YET_RECRUITING","sponsor":"University of Yalova","startDate":"2025-09-01","conditions":["Postpartum"],"enrollment":90,"completionDate":"2026-09-30"},{"nctId":"NCT04659278","phase":"NA","title":"Endourage Complete Spectrum Oral Mucosal Drops (OMD) in Adults Desiring a Reduction in Ethanol Use","status":"WITHDRAWN","sponsor":"Endourage, LLC","startDate":"2025-09","conditions":["Alcohol Drinking","Alcohol Use, Unspecified","Alcohol Abstinence","Alcohol-Related Disorders"],"enrollment":0,"completionDate":"2027-01-31"},{"nctId":"NCT07103460","phase":"NA","title":"Essential Oil-Assisted Respiratory Training in Type 2 Diabetic Patients With Lung Infections","status":"NOT_YET_RECRUITING","sponsor":"National Taipei University of Nursing and Health Sciences","startDate":"2025-07-25","conditions":["Type 2 Diabetes Mellitus (T2DM)","Pulmonary Infections","Pneumonia"],"enrollment":100,"completionDate":"2027-07-31"},{"nctId":"NCT07088601","phase":"PHASE4","title":"Efficacy of Oral Ondansetron Strips on Prevention of Post-Spinal Shivering","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-08-10","conditions":["Post-Spinal Shivering"],"enrollment":50,"completionDate":"2025-12-29"},{"nctId":"NCT07093138","phase":"PHASE4","title":"Evaluation of Efficacy and Safety of Topical Cannabidiol (Canvert-M Produced by Alasht Pharmed co. Iran) in the Treatment of Migraine Attacks","status":"RECRUITING","sponsor":"Alasht Pharmed","startDate":"2025-07-16","conditions":["Migraine Disorders"],"enrollment":30,"completionDate":"2025-09-16"},{"nctId":"NCT06936501","phase":"NA","title":"The Cooling Sensation Safe Deglution Study","status":"RECRUITING","sponsor":"Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud","startDate":"2025-05-19","conditions":["Neuromotor Dysphagia After Acute Stroke"],"enrollment":15,"completionDate":"2026-03-30"},{"nctId":"NCT05282706","phase":"PHASE1","title":"Use of Aromatherapy in Conjunction With Physical/Occupational Therapy in an Acute Care Setting","status":"ENROLLING_BY_INVITATION","sponsor":"The University of Texas Health Science Center at San Antonio","startDate":"2022-05-16","conditions":["Suffering, Physical","Nausea"],"enrollment":200,"completionDate":"2026-12"},{"nctId":"NCT05799053","phase":"PHASE3","title":"Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2022-05-12","conditions":["Irritable Bowel Syndrome","Functional Abdominal Pain Syndrome","Child","Adolescent","Therapeutics","Adverse Drug Event"],"enrollment":228,"completionDate":"2024-11-30"},{"nctId":"NCT06984848","phase":"NA","title":"Effect of Enzymatic-Containing Mouth Spray (Oral7®) on Xerostomia Symptoms, Salivary Flow Rate, and Oral Health-Related Quality of Life in Older Patients","status":"NOT_YET_RECRUITING","sponsor":"ZAINAB MAT YUDIN","startDate":"2025-08-01","conditions":["Xerostomia","Geriatric"],"enrollment":100,"completionDate":"2026-12-01"},{"nctId":"NCT06488807","phase":"NA","title":"Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment","status":"RECRUITING","sponsor":"Shanghai 10th People's Hospital","startDate":"2025-04-07","conditions":["Perioperative Neurocognitive Disorder"],"enrollment":686,"completionDate":"2028-12-31"},{"nctId":"NCT05803109","phase":"NA","title":"Efficacy of Coconut Oil With Peppermint Essential for Oral Hygiene Routine","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-08-21","conditions":["Fluoride Adverse Reaction"],"enrollment":40,"completionDate":"2025-01-01"},{"nctId":"NCT06950632","phase":"NA","title":"This Study Will Investigate the Effectiveness of Peppermint Oil Inhalation in Reducing the Intensity and Frequency of Acute Nausea and Vomiting Among Cancer Patients Undergoing Chemotherapy. Chemotherapy-induced Nausea and Vomiting (CINV) Are Among the Most Distressing Side Effects Experienced by pa","status":"NOT_YET_RECRUITING","sponsor":"University of Health Sciences Lahore","startDate":"2025-10-20","conditions":["Chemotherapy Induced Nausea and Vomiting"],"enrollment":106,"completionDate":"2026-03-31"},{"nctId":"NCT06914921","phase":"NA","title":"Enteric-Coated Peppermint Oil Versus Standard Antispasmodic in SLC6A4 (5-HTTLPR) Carriers With Irritable Bowel Syndrome.","status":"COMPLETED","sponsor":"S.LAB (SOLOWAYS)","startDate":"2024-02-04","conditions":["Irritable Bowel Syndrome (IBS)"],"enrollment":224,"completionDate":"2025-02-01"},{"nctId":"NCT05855369","phase":"PHASE2,PHASE3","title":"Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)","status":"RECRUITING","sponsor":"Medical University of South Carolina","startDate":"2023-10-02","conditions":["Smell Dysfunction","Olfactory Disorder","Long COVID"],"enrollment":180,"completionDate":"2028-05-31"},{"nctId":"NCT05613153","phase":"NA","title":"Peppermint Oil as a Treatment for Children With Bladder and Bowel Dysfunction","status":"ENROLLING_BY_INVITATION","sponsor":"Children's Hospital of Orange County","startDate":"2022-11-01","conditions":["Bladder and Bowel Dysfunction"],"enrollment":30,"completionDate":"2025-12-31"},{"nctId":"NCT06045078","phase":"NA","title":"Aromatherapy in Total Knee Replacement","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2023-10-03","conditions":["Total Knee Replacement","Post-operative Nausea and Vomiting","Opioid Use","Anxiety","Depression","Post Operative Pain"],"enrollment":30,"completionDate":"2024-04-01"},{"nctId":"NCT04984278","phase":"PHASE3","title":"Evaluation of the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple Sclerosis","status":"TERMINATED","sponsor":"Jazz Pharmaceuticals","startDate":"2021-08-16","conditions":["Spasticity With Multiple Sclerosis"],"enrollment":56,"completionDate":"2022-11-11"},{"nctId":"NCT05328973","phase":"PHASE2","title":"Intraoperative Aromatherapy Versus Placebo for Port-a-Cath Placement Under Monitored Anesthesia Care. A Randomized Controlled Trial","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2022-05-18","conditions":["Cancer Pain"],"enrollment":70,"completionDate":"2024-01-16"},{"nctId":"NCT05184478","phase":"PHASE1,PHASE2","title":"Is Medicinal Cannabis an Effective Treatment for Tourette Syndrome in Adolescents? a Pilot Study","status":"COMPLETED","sponsor":"Murdoch Childrens Research Institute","startDate":"2022-05-16","conditions":["Tourette Syndrome in Adolescence"],"enrollment":10,"completionDate":"2024-01-04"},{"nctId":"NCT03480971","phase":"PHASE2","title":"Treatment of Radiation and Cisplatin Induced Toxicities with Tempol","status":"RECRUITING","sponsor":"Matrix Biomed, Inc.","startDate":"2019-05-13","conditions":["Mucositis","Nephrotoxicity","Ototoxicity"],"enrollment":120,"completionDate":"2025-12"},{"nctId":"NCT05539560","phase":"NA","title":"The Effect of Olfactory Training in Patients With COVID-19 Induced Olfactory Dysfunction","status":"RECRUITING","sponsor":"Ditte Gertz Mogensen","startDate":"2022-06-29","conditions":["COVID-19"],"enrollment":65,"completionDate":"2025-09-30"},{"nctId":"NCT06559982","phase":"NA","title":"Effects of a Brown Seaweed Tart Cherry Blend in Mild-moderate Hypertension","status":"NOT_YET_RECRUITING","sponsor":"University of Central Lancashire","startDate":"2025-05-01","conditions":["Hypertension"],"enrollment":30,"completionDate":"2026-07-01"},{"nctId":"NCT06475482","phase":"NA","title":"Development of a Novel Polyherbal Lip Hydrant for Improving Biophysical Barrier of the Lips","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2024-01-03","conditions":["Cheilitis"],"enrollment":66,"completionDate":"2024-03-27"},{"nctId":"NCT06414161","phase":"NA","title":"Management of Radiotherapy-related Xerostomia With Green Tea and Peppermint","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-04-01","conditions":["Radiation-induced Xerostomia"],"enrollment":40,"completionDate":"2024-12"},{"nctId":"NCT05251337","phase":"PHASE2","title":"Use of Aromatherapy to Reduce Symptom Burden","status":"COMPLETED","sponsor":"Indiana University","startDate":"2022-03-07","conditions":["Anxiety","Chemotherapy-induced Nausea and Vomiting"],"enrollment":92,"completionDate":"2023-06-22"},{"nctId":"NCT04203498","phase":"PHASE3","title":"Safety and Effectiveness of Nabiximols Oromucosal Spray as Add-on Therapy in Participants With Spasticity Due to Multiple Sclerosis","status":"TERMINATED","sponsor":"Jazz Pharmaceuticals","startDate":"2020-10-01","conditions":["Multiple Sclerosis (MS)"],"enrollment":139,"completionDate":"2023-02-28"},{"nctId":"NCT03945461","phase":"NA","title":"Return of Bowel Function After One or Two Level Anterior Lumbar Interbody Fusion With Chewing Gum","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2019-02-13","conditions":["Spondylosis","Spondylolisthesis","Neurogenic Claudication","Foraminal Stenosis"],"enrollment":50,"completionDate":"2023-12-30"},{"nctId":"NCT04934969","phase":"NA","title":"The Adjunctive Use of Lavender and Peppermint Essential Oils","status":"COMPLETED","sponsor":"University Hospitals Cleveland Medical Center","startDate":"2021-07-30","conditions":["Joint Diseases"],"enrollment":3,"completionDate":"2023-08-01"},{"nctId":"NCT05091216","phase":"NA","title":"The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients","status":"COMPLETED","sponsor":"Lo-Sheng Sanatorium","startDate":"2021-10-01","conditions":["Leprosy","Hansen's Disease","Xerostomia","Plaque"],"enrollment":41,"completionDate":"2022-09-06"},{"nctId":"NCT05528094","phase":"NA","title":"An Exploratory Investigation of a Supplement to Support Student Learning","status":"COMPLETED","sponsor":"JoySpring","startDate":"2022-04-14","conditions":["Concentration Ability Impaired","Mental Fatigue"],"enrollment":38,"completionDate":"2022-12-15"},{"nctId":"NCT06148662","phase":"PHASE4","title":"The Effect of Oral Sprays on Salivary pH","status":"COMPLETED","sponsor":"I.M. Sechenov First Moscow State Medical University","startDate":"2023-12-01","conditions":["Oral Health"],"enrollment":33,"completionDate":"2024-01-25"},{"nctId":"NCT04866407","phase":"NA","title":"Topical Eucalyptus Globulus and Mentha x Piperita on Muscle Soreness in Older Adults and the Elderly","status":"TERMINATED","sponsor":"Rutgers, The State University of New Jersey","startDate":"2021-04-26","conditions":["Muscle Soreness"],"enrollment":8,"completionDate":"2022-06-30"},{"nctId":"NCT02802241","phase":"NA","title":"Effects of Open-label vs Double-blind Treatment in IBS","status":"COMPLETED","sponsor":"Beth Israel Deaconess Medical Center","startDate":"2016-06","conditions":["Irritable Bowel Syndrome","Placebo Effect","Placebos","Peppermint Oil"],"enrollment":340,"completionDate":"2019-01"},{"nctId":"NCT06208800","phase":"NA","title":"The Effect of Aromatherapy on Sleep and Cognitive Level in the Elderly","status":"UNKNOWN","sponsor":"Medipol University","startDate":"2024-01-30","conditions":["Insomnia","Cognitive Impairment","Elderly"],"enrollment":60,"completionDate":"2024-06-30"},{"nctId":"NCT04497870","phase":"PHASE1","title":"Peppermint Oil Pharmacokinetics/Dynamics","status":"WITHDRAWN","sponsor":"Baylor College of Medicine","startDate":"2020-07-09","conditions":["Abdominal Pain"],"enrollment":0,"completionDate":"2023-09-14"},{"nctId":"NCT06137027","phase":"EARLY_PHASE1","title":"Cannabidiol Oil Extract for Prevention of Postoperative Nausea and Vomiting","status":"UNKNOWN","sponsor":"The University of The West Indies","startDate":"2023-09-21","conditions":["Postoperative Nausea and Vomiting"],"enrollment":120,"completionDate":"2024-02-29"},{"nctId":"NCT05541809","phase":"NA","title":"Peppermint Aroma and Physiological Parameters","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-06-01","conditions":["Mechanical Ventilation Complication"],"enrollment":106,"completionDate":"2022-09-30"},{"nctId":"NCT06095726","phase":"NA","title":"Peppermint Inhalation Versus Swedish Massage on Chemotherapy Induced-Nausea and Vomiting in Children With Leukemia","status":"COMPLETED","sponsor":"Alexandria University","startDate":"2022-01-01","conditions":["Leukemia"],"enrollment":75,"completionDate":"2022-12-31"},{"nctId":"NCT04478630","phase":"NA","title":"The Effects of Inhaled Aromatherapy on Chemotherapy Induced Nausea (CINV) and Vomiting","status":"TERMINATED","sponsor":"Milton S. Hershey Medical Center","startDate":"2021-08-30","conditions":["Nausea","Vomiting"],"enrollment":12,"completionDate":"2023-02-18"},{"nctId":"NCT04723446","phase":"NA","title":"Efficacy of Mouthwashes in Reducing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Saliva","status":"COMPLETED","sponsor":"Queen Mary University of London","startDate":"2021-05-19","conditions":["Covid19","Coronavirus"],"enrollment":54,"completionDate":"2021-10-25"},{"nctId":"NCT04831294","phase":"NA","title":"Effects of Cannabidiol (CBD) on the Brain","status":"UNKNOWN","sponsor":"Auburn University","startDate":"2021-07-15","conditions":["CBD","Fear","Inhibition"],"enrollment":15,"completionDate":"2023-12-31"},{"nctId":"NCT05990140","phase":"NA","title":"The Effect of Peppermint Flavored Mouthwash Applied to Patients","status":"UNKNOWN","sponsor":"Ataturk University","startDate":"2023-08-15","conditions":["Postoperative Complications"],"enrollment":60,"completionDate":"2024-07-15"},{"nctId":"NCT04252209","phase":"PHASE3","title":"the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-03-22","conditions":["Sjogren's Syndrome","Xerostomia"],"enrollment":24,"completionDate":"2023-03-15"},{"nctId":"NCT05617144","phase":"NA","title":"Aromatherapy Protocol for Pain Reduction in Hospice Patients","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2022-12-12","conditions":["Pain"],"enrollment":6,"completionDate":"2023-01-12"},{"nctId":"NCT04560114","phase":"PHASE2","title":"Effect of Inhaled Aromatherapy on Chemo-Induced Nausea Vomiting (NCVI): CINVAROM (Chemotherapy Induced Nausea Vomiting and AROMatherapy)","status":"COMPLETED","sponsor":"Centre Francois Baclesse","startDate":"2020-12-14","conditions":["Nausea and Vomiting","Aromatherapy","Essential Oil","Suportive Care"],"enrollment":96,"completionDate":"2023-06-30"},{"nctId":"NCT05136066","phase":"NA","title":"Effects of Massage With Peppermint Oil on Labor Pain","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2021-11-13","conditions":["Labor Pain"],"enrollment":60,"completionDate":"2023-05-15"},{"nctId":"NCT04657666","phase":"PHASE3","title":"Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple Sclerosis","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2020-12-21","conditions":["Spasticity in Participants With Multiple Sclerosis"],"enrollment":68,"completionDate":"2022-05-10"},{"nctId":"NCT04800744","phase":"NA","title":"Aromatherapy for Improving Post-Surgical Quality of Life","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2021-03-22","conditions":["Quality of Life","Anxiety Postoperative"],"enrollment":70,"completionDate":"2023-05-17"},{"nctId":"NCT01606137","phase":"PHASE3","title":"A Study of the Long-term Safety of Sativex Use","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2002-02","conditions":["Multiple Sclerosis","Spasticity","Pain"],"enrollment":507,"completionDate":"2004-12"},{"nctId":"NCT05839236","phase":"PHASE1","title":"COVID-19 Vaccination Detoxification in LDL-C","status":"UNKNOWN","sponsor":"Yang I. Pachankis","startDate":"2023-05-01","conditions":["COVID-19 Stress Syndrome","COVID-19 Vaccine Adverse Reaction","COVID-19-Associated Thromboembolism","COVID-19 Post-Intensive Care Syndrome","COVID-19-Associated Stroke","COVID-19 Respiratory Infection"],"enrollment":1,"completionDate":"2023-07-31"},{"nctId":"NCT00702468","phase":"PHASE3","title":"Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2007-11","conditions":["Spasticity","Multiple Sclerosis"],"enrollment":36,"completionDate":"2009-01"},{"nctId":"NCT00681538","phase":"PHASE3","title":"A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS)","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2008-01","conditions":["Spasticity","Multiple Sclerosis"],"enrollment":572,"completionDate":"2009-01"},{"nctId":"NCT00711646","phase":"PHASE3","title":"A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis.","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2002-06","conditions":["Spasticity","Multiple Sclerosis"],"enrollment":189,"completionDate":"2004-03"},{"nctId":"NCT01599234","phase":"PHASE3","title":"A Study to Evaluate the Efficacy of Sativex in Relieving Symptoms of Spasticity Due to Multiple Sclerosis","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2005-03","conditions":["Multiple Sclerosis"],"enrollment":337,"completionDate":"2005-12"},{"nctId":"NCT00710424","phase":"PHASE3","title":"A Study of Sativex® for Pain Relief Due to Diabetic Neuropathy","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2005-07","conditions":["Pain","Diabetic Neuropathy"],"enrollment":297,"completionDate":"2006-06"},{"nctId":"NCT00710554","phase":"PHASE3","title":"A Study of Sativex® for Pain Relief of Peripheral Neuropathic Pain, Associated With Allodynia","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2005-08","conditions":["Pain","Peripheral Neuropathy"],"enrollment":246,"completionDate":"2006-10"},{"nctId":"NCT00713817","phase":"PHASE3","title":"A Study to Determine the Maintenance of Effect After Long-term Treatment of Sativex® in Subjects With Neuropathic Pain","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2007-03","conditions":["Pain","Peripheral Neuropathy"],"enrollment":19,"completionDate":"2007-07"},{"nctId":"NCT00713323","phase":"PHASE3","title":"A Study to Compare the Safety and Tolerability of Sativex® in Patients With Neuropathic Pain.","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2005-10","conditions":["Pain","Peripheral Neuropathy"],"enrollment":380,"completionDate":"2007-06"},{"nctId":"NCT05832463","phase":"NA","title":"Effects of a Novel Supplement on Glycemic Variability Measured by Continuous Glucose Monitoring","status":"COMPLETED","sponsor":"dōTERRA International","startDate":"2021-05-14","conditions":["Healthy"],"enrollment":43,"completionDate":"2022-07-15"},{"nctId":"NCT00711880","phase":"PHASE3","title":"A Study of Sativex® for Relief of Peripheral Neuropathic Pain Associated With Allodynia.","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2002-05","conditions":["Pain","Peripheral Neuropathy"],"enrollment":125,"completionDate":"2004-03"},{"nctId":"NCT01337089","phase":"PHASE3","title":"Long Term Safety of Sativex Oromucosal Spray (Sativex®; Nabiximols) as Adjunctive Therapy in Patients With Uncontrolled Persistent Chronic Cancer Related Pain","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2011-01-19","conditions":["Pain","Advanced Cancer"],"enrollment":660,"completionDate":"2016-01-27"},{"nctId":"NCT01424566","phase":"PHASE3","title":"A Two-Part Study of Sativex® Oromucosal Spray for Relieving Uncontrolled Persistent Pain in Patients With Advanced Cancer","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2012-06-29","conditions":["Pain","Advanced Cancer"],"enrollment":406,"completionDate":"2015-12-28"},{"nctId":"NCT01361607","phase":"PHASE3","title":"Sativex® for Relieving Persistent Pain in Patients With Advanced Cancer","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2011-05-27","conditions":["Pain","Advanced Cancer"],"enrollment":399,"completionDate":"2014-11-24"},{"nctId":"NCT05559814","phase":"NA","title":"Intraluminal Peppermint Oil and Adenoma Detection Rate in Screening Colonoscopy","status":"COMPLETED","sponsor":"Mahidol University","startDate":"2021-03-01","conditions":["Colonic Polyp"],"enrollment":404,"completionDate":"2022-06-30"},{"nctId":"NCT05071833","phase":"NA","title":"Effects of Peppermint Oil in Cardiometabolic Outcomes","status":"COMPLETED","sponsor":"University of Central Lancashire","startDate":"2021-11-01","conditions":["Cardiometabolic Syndrome"],"enrollment":36,"completionDate":"2022-11-05"},{"nctId":"NCT05520411","phase":"NA","title":"Examining the Effectiveness of Digestive Enzymes at Reducing Bloating and Stomach Distension","status":"COMPLETED","sponsor":"HUM Nutrition, Inc.","startDate":"2022-07-01","conditions":["Stomach Distended","Bloating"],"enrollment":25,"completionDate":"2023-01-15"},{"nctId":"NCT05677698","phase":"NA","title":"Menoupausal Symptoms and Aromatherapy","status":"COMPLETED","sponsor":"KTO Karatay University","startDate":"2022-12-27","conditions":["Aromatherapy"],"enrollment":90,"completionDate":"2023-02-27"},{"nctId":"NCT01610700","phase":"PHASE3","title":"An Investigation of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Patients","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2001-05","conditions":["Multiple Sclerosis"],"enrollment":160,"completionDate":"2002-07"},{"nctId":"NCT01964547","phase":"PHASE4","title":"A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2012-01","conditions":["Multiple Sclerosis","Spasticity"],"enrollment":121,"completionDate":"2013-05"},{"nctId":"NCT01606189","phase":"PHASE3","title":"A Study to Compare Sublingual Cannabis Based Medicine Extracts With Placebo to Treat Brachial Plexus Injury Pain","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2001-12","conditions":["Pain"],"enrollment":48,"completionDate":"2002-09"},{"nctId":"NCT01610713","phase":"PHASE3","title":"An Study to Investigate the Efficacy of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2001-05","conditions":["Multiple Sclerosis"],"enrollment":154,"completionDate":"2002-07"},{"nctId":"NCT01604265","phase":"PHASE3","title":"A Study of Sativex in the Treatment of Central Neuropathic Pain Due to Multiple Sclerosis","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2002-03","conditions":["Multiple Sclerosis","Neuropathic Pain"],"enrollment":66,"completionDate":"2002-08"},{"nctId":"NCT01606202","phase":"PHASE3","title":"A Study of Cannabis Based Medicine Extracts and Placebo in Patients With Pain Due to Spinal Cord Injury","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2002-07","conditions":["Pain"],"enrollment":116,"completionDate":"2005-01"},{"nctId":"NCT01898520","phase":"PHASE3","title":"A Safety, Efficacy and Tolerability Study of Sativex for the Treatment of Spasticity in Children Aged 8 to 18 Years","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2013-12","conditions":["Cerebral Palsy"],"enrollment":72,"completionDate":"2017-03"},{"nctId":"NCT01812616","phase":"PHASE1,PHASE2","title":"A Safety Study of Sativex Compared With Placebo (Both With Dose-intense Temozolomide) in Recurrent Glioblastoma Patients","status":"COMPLETED","sponsor":"Jazz Pharmaceuticals","startDate":"2014-09","conditions":["Cancer"],"enrollment":21,"completionDate":"2016-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Oral"},"crossReferences":{"UNII":"H0G9379FGK","RXCUI":"308892","SPL_ID":"42c4b70c-deb0-84c1-e063-6394a90ac951","chemblId":"CHEMBL2108758"},"formularyStatus":[],"_enricherVersion":"v2-openfda","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"Target Corporation","relationship":"Original Developer"}],"publicationCount":1983,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"originalDeveloper":"Target Corporation","recentPublications":[{"date":"2026 Mar 30","pmid":"41912996","title":"Pseudomonas fluorescens improves morph-physiological characteristics, essential oil compounds, and gene expression implicated in menthol biosynthesis under water stress conditions in peppermint.","journal":"Antonie van Leeuwenhoek"},{"date":"2026 Mar 23","pmid":"41881284","title":"Nose-to-Brain delivery of genistein-loaded peppermint lipid nanocapsules for neuroprotection against Alzheimer's Disease: Formulation, Characterization, pharmacokinetic and Pharmacodynamic studies.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"2026 Mar 21","pmid":"41871816","title":"Synergistic anti-Candida effects of essential oil blends on biofilms at various maturation stages.","journal":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences"},{"date":"2025 Nov 25","pmid":"41866875","title":"Expert Opinion on the Efficacy and Safety of Antispasmodics with a Focus on Irritable Bowel Syndrome.","journal":"The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology"},{"date":"2026 Mar 20","pmid":"41865907","title":"Impacts of flavor and aromatic palatants on consumption behavior in nursing foals.","journal":"Journal of equine veterinary science"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"Target Corporation","companyId":"target-corporation","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":6,"withResults":1},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:33:58.218573+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}